Results 31 to 40 of about 1,940,445 (217)

Reference Based Genome Compression [PDF]

, 2012
DNA sequencing technology has advanced to a point where storage is becoming the central bottleneck in the acquisition and mining of more data. Large amounts of data are vital for genomics research, and generic compression tools, while viable, cannot ...
Chern, Bobbie, Manolakos, Alexandros, No, Albert, Ochoa, Idoia, Venkat, Kartik, Weissman, Tsachy   +5 more
core   +2 more sources

Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichordafelina SYSU-MS7908

Marine Drugs, 2022
Culturing ascidian-derived fungus Amphichorda felina SYSU-MS7908 under standard laboratory conditions mainly yielded meroterpenoid, and nonribosomal peptide-type natural products.
Siwen Yuan, Litong Chen, Qilin Wu, Minghua Jiang, Heng Guo, Zhibo Hu, Senhua Chen, Lan Liu, Zhizeng Gao   +8 more
doaj   +1 more source

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +2 more sources

Data mining of rice genome

浙江大学学报. 农业与生命科学版, 2005
In this review, we focus on four recent advances in rice genome analysis: an whole genome duplication which is believed to occur in rice genome; evolution of rice genome size; the indica-japonic divergence that was likely to occur later than the previous
FAN Long-jiang, GUO Xing-yi
doaj   +1 more source

Multiplex Base-Editing Enables Combinatorial Epigenetic Regulation for Genome Mining of Fungal Natural Products.

Journal of the American Chemical Society, 2022
Genome mining of cryptic natural products (NPs) remains challenging, especially in filamentous fungi, owing to their complex genetic regulation. Increasing evidence indicates that several epigenetic modifications often act cooperatively to control fungal
Fanglong Zhao, Chunxiao Sun, Zhiwen Liu, Alan Cabrera, Mario Escobar, Shunyu Huang, Qichen Yuan, Qiuyue Nie, K. Luo, Angela S. P. Lin, Jeffrey A Vanegas, T. Zhu, Isaac B. Hilton, Xue Gao   +13 more
semanticscholar   +1 more source

Marine-Derived Streptomyces sennicomposti GMY01 with Anti-Plasmodial and Anticancer Activities: Genome Analysis, In Vitro Bioassay, Metabolite Profiling, and Molecular Docking

Microorganisms, 2023
To discover novel antimalarial and anticancer compounds, we carried out a genome analysis, bioassay, metabolite profiling, and molecular docking of marine sediment actinobacteria strain GMY01. The whole-genome sequence analysis revealed that Streptomyces
Jaka Widada, Ema Damayanti, Mustofa Mustofa, Achmad Dinoto, Rifki Febriansah, Triana Hertiani   +5 more
doaj   +1 more source

Generate a bioactive natural product library by mining bacterial cytochrome P450 patterns

Synthetic and Systems Biotechnology, 2016
The increased number of annotated bacterial genomes provides a vast resource for genome mining. Several bacterial natural products with epoxide groups have been identified as pre-mRNA spliceosome inhibitors and antitumor compounds through genome mining ...
Xiangyang Liu
doaj   +1 more source

Pseudomonassin, a New Bioactive Ribosomally Synthesised and Post-Translationally Modified Peptide from Pseudomonas sp. SST3

Microorganisms, 2023
Genome mining and metabolomics have become valuable tools in natural products research to evaluate and identify potential new chemistry from bacteria. In the search for new compounds from the deep-sea organism, Pseudomonas sp.
Kevin Jace Miranda, Saif Jaber, Dana Atoum, Subha Arjunan, Rainer Ebel, Marcel Jaspars, RuAngelie Edrada-Ebel   +6 more
doaj   +1 more source

Genome mining for drug discovery: progress at the front end

Journal of Industrial Microbiology & Biotechnology, 2021
Microbial genome mining for drug discovery and development has been accelerating in recent years, driven by technical advancements in genome sequencing, bioinformatics, metabolomics/metabologenomics, and synthetic biology.
R. H. Baltz
semanticscholar   +1 more source

Data Mining of the Coffee Rust Genome [PDF]

, 2012
The genomes of nine isolates of _Hemileia vastatrix_, the causal agent of coffee leaf rust were sequenced by Illumina and 454. Quality control, cleaning and _de novo_ assemblies of data were performed.
Alvaro Gaitan, David Octavio Botero-Rozo, Diego M. Riañ, Marco Cristancho, Silvia Restrepo, William Giraldo   +5 more
core   +2 more sources