Results 41 to 50 of about 105,282 (228)
Integration and mining of malaria molecular, functional and pharmacological data: how far are we from a chemogenomic knowledge space? [PDF]
, 2006 The organization and mining of malaria genomic and post-genomic data is highly motivated by the necessity to predict and characterize new biological targets and new drugs. Biological targets are sought in a biological space designed from the genomic data
Bastien, Olivier +14 more
core +4 more sources
Chemistry & Biology, 2007 In this issue of Chemistry & Biology, Gross et al. report development of a novel genome mining method for isolating products of orphan biosynthetic gene clusters, and the application of this method to the isolation of orfamide A, a novel cyclic lipopeptide.
Corre, Christophe, Challis, Gregory L.
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Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery
Marine Drugs, 2022 Large-scale genome-mining analyses have identified an enormous number of cryptic biosynthetic gene clusters (BGCs) as a great source of novel bioactive natural products.
Jessie James Limlingan Malit +2 more
doaj +1 more source
Uncovering protein interaction in abstracts and text using a novel linear model and word proximity networks [PDF]
, 2008 We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages characterizing ...
Abi-Haidar, Alaa +7 more
core +4 more sources
How to Completely Squeeze a Fungus—Advanced Genome Mining Tools for Novel Bioactive Substances
Pharmaceutics, 2022 Fungal species have the capability of producing an overwhelming diversity of bioactive substances that can have beneficial but also detrimental effects on human health.
Andreas Schüller +2 more
doaj +1 more source
Unveiling combinatorial regulation through the combination of ChIP information and in silico cis-regulatory module detection [PDF]
, 2012 Computationally retrieving biologically relevant cis-regulatory modules (CRMs) is not straightforward. Because of the large number of candidates and the imperfection of the screening methods, many spurious CRMs are detected that are as high scoring as ...
Fierro, Ana Carolina +5 more
core +2 more sources
PLoS Computational Biology, 2008 As data banks increase their size, one of the current challenges in bioinformatics is to be able to query them in a sensible way. Information is contained in different databases, with various data representations or formats, making it very difficult to use a single query tool to search more than a single data source.
Xosé M Fernández-Suárez, Ewan Birney
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Journal of Integrative Bioinformatics, 2011 In nowadays life science projects, sharing data and data interpretation is becoming increasingly important. This considerably calls for novel information technology approaches, which enable the integration of expert knowledge from different disciplines ...
Loyek Christian +3 more
doaj +1 more source
Mining Natural Product Biosynthesis in Eukaryotic Algae
Marine Drugs, 2020 Eukaryotic algae are an extremely diverse category of photosynthetic organisms and some species produce highly potent bioactive compounds poisonous to humans or other animals, most notably observed during harmful algal blooms.
Ellis O’Neill
doaj +1 more source
Mining the genome for lipid genes
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2014 Mining of the genome for lipid genes has since the early 1970s helped to shape our understanding of how triglycerides are packaged (in chylomicrons), repackaged (in very low density lipoproteins; VLDL), and hydrolyzed, and also how remnant and low-density lipoproteins (LDL) are cleared from the circulation.
Kuivenhoven, Jan Albert +1 more
openaire +2 more sources