Results 41 to 50 of about 1,940,445 (217)

Advanced Genomic Data Mining

open access: yesPLoS Computational Biology, 2008
As data banks increase their size, one of the current challenges in bioinformatics is to be able to query them in a sensible way. Information is contained in different databases, with various data representations or formats, making it very difficult to use a single query tool to search more than a single data source.
Xosé M Fernández-Suárez, Ewan Birney
openaire   +4 more sources

Use of whole-genus genome sequence data to develop a multilocus sequence typing tool that accurately identifies Yersinia isolates to the species and subspecies levels [PDF]

open access: yes, 2015
The genus Yersinia is a large and diverse bacterial genus consisting of human-pathogenic species, a fish-pathogenic species, and a large number of environmental species.
Carniel, Elisabeth   +13 more
core   +1 more source

Enhanced Bacterial Foraging Optimization Based on Progressive Exploitation Toward Local Optimum and Adaptive Raid

open access: yesIEEE Access, 2019
Since the bacterial foraging optimization algorithm (BFO) was proposed, many variants about it have been designed in order to improve the performance and applied in different fields.
Dongxing Wang   +5 more
doaj   +1 more source

The potential of text mining in data integration and network biology for plant research : a case study on Arabidopsis [PDF]

open access: yes, 2013
Despite the availability of various data repositories for plant research, a wealth of information currently remains hidden within the biomolecular literature. Text mining provides the necessary means to retrieve these data through automated processing of
De Bodt, Stefanie   +4 more
core   +2 more sources

Computational Genomics of Specialized Metabolism: from Natural Product Discovery to Microbiome Ecology

open access: yesmSystems, 2018
Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development.
Marnix H. Medema
doaj   +1 more source

Activation and Identification of a Griseusin Cluster in Streptomyces sp. CA-256286 by Employing Transcriptional Regulators and Multi-Omics Methods

open access: yesMolecules, 2021
Streptomyces are well-known producers of a range of different secondary metabolites, including antibiotics and other bioactive compounds. Recently, it has been demonstrated that “silent” biosynthetic gene clusters (BGCs) can be activated by ...
Charlotte Beck   +13 more
doaj   +1 more source

antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters

open access: yesNucleic Acids Res., 2015
Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key ...
T. Weber   +12 more
semanticscholar   +1 more source

Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining.

open access: yesNatural product reports (Print), 2022
Covering: 2010 to 2022Heterologous expression of natural product biosynthetic gene clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways, bottom-up investigation of biosynthetic enzymes, and engineered biosynthesis of new ...
Chen-Yu Chiang, M. Ohashi, Yi Tang
semanticscholar   +1 more source

Phylogenomic analysis of natural products biosynthetic gene clusters allows discovery of arseno-organic metabolites in model streptomycetes [PDF]

open access: yes, 2016
We are indebted with Marnix Medema, Paul Straight and Sean Rovito, for useful discussions and critical reading of the manuscript, as well as with Alicia Chagolla and Yolanda Rodriguez of the MS Service of Unidad Irapuato, Cinvestav, and Araceli Fernandez
Barona-Gomez, Francisco   +7 more
core   +1 more source

Complete Genome Sequence of Two Deep-Sea Streptomyces Isolates from Madeira Archipelago and Evaluation of Their Biosynthetic Potential

open access: yesMarine Drugs, 2021
The deep-sea constitutes a true unexplored frontier and a potential source of innovative drug scaffolds. Here, we present the genome sequence of two novel marine actinobacterial strains, MA3_2.13 and S07_1.15, isolated from deep-sea samples (sediments ...
Pedro Albuquerque   +7 more
doaj   +1 more source

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