Results 41 to 50 of about 1,743,586 (380)
Genome mining for drug discovery: progress at the front end
Journal of Industrial Microbiology & Biotechnology, 2021 Microbial genome mining for drug discovery and development has been accelerating in recent years, driven by technical advancements in genome sequencing, bioinformatics, metabolomics/metabologenomics, and synthetic biology.
R. H. Baltz
semanticscholar +1 more source
Frontiers in Microbiology, 2021 Bacillus pumilus 64-1, a bacterial strain isolated from the marine sponge Plakina cyanorosea, which exhibits antimicrobial activity against both pathogenic and drug-resistant Gram-positive and Gram-negative bacteria.
Jéssyca Freitas-Silva +7 more
doaj +1 more source
Predicting Combinatorial Binding of Transcription Factors to Regulatory Elements in the Human Genome by Association Rule Mining [PDF]
, 2007 Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Although some cisregulatory elements have been well studied, the combinations of transcription
Iyer, Vishwanath R. +3 more
core +2 more sources
Mining the draft human genome [PDF]
Nature, 2001 Now that the draft human genome sequence is available, everyone wants to be able to use it. However, we have perhaps become complacent about our ability to turn new genomes into lists of genes. The higher volume of data associated with a larger genome is accompanied by a much greater increase in complexity.
Birney, E +3 more
openaire +4 more sources
Multiple Genome Analytics Framework: The Case of All SARS-CoV-2 Complete Variants [PDF]
, 2022 Pattern detection and string matching are fundamental problems in computer science and the accelerated expansion of bioinformatics and computational biology have made them a core topic for both disciplines. The SARS-CoV-2 pandemic has made such problems more demanding with hundreds or thousands of new genome variants discovered every week, because of ...
arxiv +1 more source
mSystems, 2018 Microbial and plant specialized metabolites, also known as natural products, are key mediators of microbe-microbe and host-microbe interactions and constitute a rich resource for drug development.
Marnix H. Medema
doaj +1 more source
PROPHECY—a database for high-resolution phenomics [PDF]
, 2004 The rapid recent evolution of the field phenomics—the genome-wide study of gene dispensability by quantitative analysis of phenotypes—has resulted in an increasing demand for new data analysis and visualization tools.
Blomberg, Anders +6 more
core +2 more sources
antiSMASH 3.0—a comprehensive resource for the genome mining of biosynthetic gene clusters
Nucleic Acids Res., 2015 Microbial secondary metabolism constitutes a rich source of antibiotics, chemotherapeutics, insecticides and other high-value chemicals. Genome mining of gene clusters that encode the biosynthetic pathways for these metabolites has become a key ...
T. Weber +12 more
semanticscholar +1 more source
Genome mining of biosynthetic and chemotherapeutic gene clusters in Streptomyces bacteria
Scientific Reports, 2020 Streptomyces bacteria are known for their prolific production of secondary metabolites, many of which have been widely used in human medicine, agriculture and animal health.
Kaitlyn C Belknap +3 more
semanticscholar +1 more source
PLoS Computational Biology, 2008 As data banks increase their size, one of the current challenges in bioinformatics is to be able to query them in a sensible way. Information is contained in different databases, with various data representations or formats, making it very difficult to use a single query tool to search more than a single data source.
Ewan Birney, Xosé M. Fernández-Suárez
openaire +5 more sources