Results 81 to 90 of about 105,282 (228)

Nutritional c‐Fos Induction Rewires Hepatic Metabolism and Can Promote Obesity‐Associated Hepatocellular Carcinoma

Advanced Science, EarlyView.
It is shown that hepatic c‐Fos responds to feeding, altering de novo lipogenesis, glycolysis, and a wide range of steatosis‐associated metabolic signaling pathways. Obesogenic diets cause hepatic c‐Fos overexpression, insulin resistance, and the induction of metabolic reprogramming‐related genes.
Ao Li, Eduardo H. Gilglioni, Wadsen St‐Pierre‐Wijckmans, Leila Hosseinzadeh, Christelle Veyrat‐Durebex, Sumeet Pal Singh, Roberto Coppari, Latifa Bakiri, Esteban N. Gurzov   +8 more
wiley   +1 more source

Interpreting Microbial Biosynthesis in the Genomic Age: Biological and Practical Considerations

Marine Drugs, 2017
Genome mining has become an increasingly powerful, scalable, and economically accessible tool for the study of natural product biosynthesis and drug discovery.
Ian J. Miller, Marc G. Chevrette, Jason C. Kwan   +2 more
doaj   +1 more source

The Discovery of New Antilisterial Proteins From Paenibacillus polymyxa Kp10 via Genome Mining and Mass Spectrometry

Frontiers in Microbiology, 2020
The inhibitory properties of novel antimicrobial proteins against food-borne pathogens such as Listeria monocytogenes offer extensive benefits to the food and medical industries.
Nur Fadhilah Khairil Mokhtar, Nur Fadhilah Khairil Mokhtar, Amalia Mohd Hashim, Amalia Mohd Hashim, Irwan Hanish, Aisyah Zulkarnain, Raja Mohd Hafidz Raja Nhari, Asmahani Azira Abdul Sani, Sahar Abbasiliasi, Arbakariya Ariff, Shuhaimi Mustafa, Shuhaimi Mustafa, Shuhaimi Mustafa, Raha Abdul Rahim, Raha Abdul Rahim   +14 more
doaj   +1 more source

Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria

Frontiers in Microbiology, 2022
Multi-omic approaches have recently made big strides toward the effective exploration of microorganisms, accelerating the discovery of new bioactive compounds. We combined metabolomic, molecular networking, and genomic-based approaches to investigate the
Rima Ouchene, Rima Ouchene, Didier Stien, Juliette Segret, Mouloud Kecha, Alice M. S. Rodrigues, Carole Veckerlé, Marcelino T. Suzuki   +7 more
doaj   +1 more source

Genome mining and functional genomics for siderophore production in Aspergillus niger [PDF]

Briefings in Functional Genomics, 2014
Iron is an essential metal for many organisms, but the biologically relevant form of iron is scarce because of rapid oxidation resulting in low solubility. Simultaneously, excessive accumulation of iron is toxic. Consequently, iron uptake is a highly controlled process.
Franken, A.C.W., Lechner, B.E., Werner, E.R., Haas, H., Lokman, B.C., Ram, A.F.J., Hondel, C.A.M.J.J. van den, Weert, S. de, Punt, P.J.   +8 more
openaire   +4 more sources

ARL3 Enhances ERα Stability via USP10 Deubiquitination to Promote Endocrine Resistance and Drive Mitochondrial Metabolic Reprogramming in HR+ Breast Cancer

Advanced Science, EarlyView.
This study identifies ADP‐ribosylation factor‐like protein 3 (ARL3) as a novel chaperone that stabilizes estrogen receptor α (ERα) in breast cancer. ARL3 promotes tumor growth by recruiting USP10 to remove ubiquitin chains from ERα, preventing its degradation.
Han Li, Yang Liu, Zehao Cai, Kang Li, Shun Gao, Ailin Lan, Dan Shu, Kuan He, Xin Liu, Yang Peng, Shipeng Guo, Haochen Yu, Aishun Jin, Meiying Shen, Shengchun Liu   +14 more
wiley   +1 more source

Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143

Frontiers in Chemistry, 2020
Overexpression of the PbrlaeA gene of the fungus Penicillium brocae HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (1), whose configuration has not been reported before, and one new compound iso-fumigatin ...
Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang, Guojian Zhang, Dehai Li, Dehai Li   +9 more
doaj   +1 more source

Mining the Genome of

Frontiers in Microbiology, 2018
Actinobacteria are an important source of commercial (bio)compounds for the biotechnological and pharmaceutical industry. They have also been successfully exploited in the search of novel biocatalysts. We set out to explore a recently identified actinomycete, Streptomyces leeuwenhoekii C34, isolated from a hyper-arid region, the Atacama desert, for ...
Gran-Scheuch, Alejandro, Trajkovic, Milos, Parra, Loreto, Fraaije, Marco W   +3 more
openaire   +1 more source

Mining the Bovine Genome with the “Bovine SNP Retriever” [PDF]

Journal of Heredity, 2008
Online resources for the bovine genome analysis are provided at the most important Web sites. Nonetheless, retrieval of single-nucleotide polymorphism (SNP)-related information is not always easy when searches must focus on complementary features. In this work, we present the Bovine SNP Retriever: a user-friendly tool for bovine SNP retrieval that also
Panzitta Francesca, Caprera Andrea, Merelli Ivan, Milanesi Luciano, Williams John L, Lazzari Barbara, Stella Alessandra   +6 more
openaire   +7 more sources

CSN6 Promotes Pancreatic Cancer Progression and Gemcitabine Resistance via Antagonizing DCAF1‐Mediated Ubiquitination of NPM1

Advanced Science, EarlyView.
COP9 signalosome subunit 6 (CSN6) promotes the auto‐ubiquitination and degradation of DDB1‐CUL4 associated factor 1 (DCAF1), thereby antagonizing DCAF1‐mediated ubiquitination of Nucleophosmin (NPM1). This stabilization of NPM1 enhances the ribosome biogenesis process and the translation of specific gemcitabine‐resistance proteins, ultimately driving ...
Yijing Zhang, Han Gao, Aiwen Tang, Haiwen Lyu, Zongmin Fan, Jiahui Guo, Yuzhi Wang, Hairong Yi, Qihao Pan, Haidan Luo, Baifu Qin, Boyu Zhang, Xiangqi Meng, Qingxin Liu, Mong‐Hong Lee   +14 more
wiley   +1 more source