Results 81 to 90 of about 176,908 (324)

The Discovery of New Antilisterial Proteins From Paenibacillus polymyxa Kp10 via Genome Mining and Mass Spectrometry

Frontiers in Microbiology, 2020
The inhibitory properties of novel antimicrobial proteins against food-borne pathogens such as Listeria monocytogenes offer extensive benefits to the food and medical industries.
Nur Fadhilah Khairil Mokhtar, Nur Fadhilah Khairil Mokhtar, Amalia Mohd Hashim, Amalia Mohd Hashim, Irwan Hanish, Aisyah Zulkarnain, Raja Mohd Hafidz Raja Nhari, Asmahani Azira Abdul Sani, Sahar Abbasiliasi, Arbakariya Ariff, Shuhaimi Mustafa, Shuhaimi Mustafa, Shuhaimi Mustafa, Raha Abdul Rahim, Raha Abdul Rahim   +14 more
doaj   +1 more source

Integrated Metabolomic, Molecular Networking, and Genome Mining Analyses Uncover Novel Angucyclines From Streptomyces sp. RO-S4 Strain Isolated From Bejaia Bay, Algeria

Frontiers in Microbiology, 2022
Multi-omic approaches have recently made big strides toward the effective exploration of microorganisms, accelerating the discovery of new bioactive compounds. We combined metabolomic, molecular networking, and genomic-based approaches to investigate the
Rima Ouchene, Rima Ouchene, Didier Stien, Juliette Segret, Mouloud Kecha, Alice M. S. Rodrigues, Carole Veckerlé, Marcelino T. Suzuki   +7 more
doaj   +1 more source

Antimicrobial antagonists against food pathogens; a bacteriocin perspective [PDF]

, 2015
peer-reviewedEfforts are continuing to find novel bacteriocins with enhanced specificity and potency. Traditional plating techniques are still being used for bacteriocin screening studies, however, the availability of ever more bacterial genome sequences
Cotter, Paul D., Hill, Colin, O'Connor, Paula M., Ross, R Paul   +3 more
core   +1 more source

Microglial HVCN1 Deficiency Improves Movement and Survival of SOD1G93A ALS Mice by Enhancing Microglial Migration and Neuroprotection

Advanced Science, EarlyView.
Hydrogen voltage gated channel 1 (HVCN1) is upregulated in microglia of both ALS patients and its mouse model. HVCN1 deficiency enhances microglial migration via suppressing Akt signaling, promotes neurotrophic capacity and motor function, and prolongs survival of the SOD1G93A ALS mice. This study identifies HVCN1 as a novel, promising druggable target
Fan Wang, Ke‐Yu Zhang, Lang‐Jian Zhu, Wei‐Jue Li, Yang Wu, Xiang Gao, Xiao‐Ru Ma, Xiu‐Hua Yin, Jian‐Bin Wu, Xiao‐Kang Ye, Zhao‐Jun Dong, Di‐Xian Wang, Zhe Zhou, Shao‐Dong Wang, Lei Han, Zhi‐Nong Jiang, Jing‐Wei Zhao   +16 more
wiley   +1 more source

Overexpression of Global Regulator PbrlaeA Leads to the Discovery of New Polyketide in Fungus Penicillium Brocae HDN-12-143

Frontiers in Chemistry, 2020
Overexpression of the PbrlaeA gene of the fungus Penicillium brocae HDN-12-143 resulted in the isolation of four compounds including fumigatin chlorohydrin (1), whose configuration has not been reported before, and one new compound iso-fumigatin ...
Lu Wang, Xianyan Zhang, Kaijin Zhang, Xiaomin Zhang, Tianjiao Zhu, Qian Che, Guojian Zhang, Guojian Zhang, Dehai Li, Dehai Li   +9 more
doaj   +1 more source

A large scale prediction of bacteriocin gene blocks suggests a wide functional spectrum for bacteriocins

, 2015
Bacteriocins are peptide-derived molecules produced by bacteria, whose recently-discovered functions include virulence factors and signalling molecules as well as their better known roles as antibiotics.
Freed, Stefan D, Friedberg, Iddo, Lee, Shaun W, Morton, James T   +3 more
core   +1 more source

WormBase: A modern Model Organism Information Resource [PDF]

, 2020
WormBase (https://wormbase.org/) is a mature Model Organism Information Resource supporting researchers using the nematode Caenorhabditis elegans as a model system for studies across a broad range of basic biological processes.
et al,, Harris, Todd W, Schedl, Tim
core   +1 more source

Uncovering protein interaction in abstracts and text using a novel linear model and word proximity networks [PDF]

, 2008
We participated in three of the protein-protein interaction subtasks of the Second BioCreative Challenge: classification of abstracts relevant for protein-protein interaction (IAS), discovery of protein pairs (IPS) and text passages characterizing ...
Abi-Haidar, Alaa, Kaur, Jasleen, Maguitman, Ana G., Radivojac, Predrag, Retchsteiner, Andreas, Rocha, Luis M., Verspoor, Karin, Wang, Zhiping   +7 more
core   +4 more sources

Autopolyploidization‐Induced Chromatin Remodeling Regulates Leaf Size Variation in Brassica rapa

Advanced Science, EarlyView.
This study demonstrates that monoploid, diploid, and autotetraploid Brassica rapa lines derived from the same genome exhibit distinct leaf morphology. Ploidy changes remodel chromatin accessibility and histone modifications to regulate gene expression, while key transcription factors BrGRF13 and BrARF11 control leaf size and polarity, driving ...
Haoyuan Dong, Yanhong Liu, Yuanming Liu, Shuxin Xuan, Huanhuan Chen, Lai Wei, Guibao Zhang, Hongcui Pei, Zilong Dai, Yanhua Wang, Jinzhu Qiao, Shuangxia Luo, Xueping Chen, Yiguo Hong, Jianjun Zhao, Shuxing Shen, Zefu Lu, Aixia Gu   +17 more
wiley   +1 more source

Automated, self-resistance gene-guided, and high-throughput genome mining of bioactive natural products from Streptomyces [PDF]

, 2023
Yujie Yuan, Chunshuai Huang, Nilmani Singh, Guanhua Xun, Huimin Zhao   +4 more
openalex   +1 more source