Complete Genome Sequencing of Leptospira interrogans Isolates from Malaysia Reveals Massive Genome Rearrangement but High Conservation of Virulence-Associated Genes [PDF]
Pathogens, 2021 The ability of Leptospirae to persist in environments and animal hosts but to cause clinically highly variable disease in humans has made leptospirosis the most common zoonotic disease.
Siti Roszilawati Ramli +8 more
doaj +2 more sources
New algorithms for structure informed genome rearrangement [PDF]
Algorithms for Molecular Biology, 2023 We define two new computational problems in the domain of perfect genome rearrangements, and propose three algorithms to solve them. The rearrangement scenarios modeled by the problems consider Reversal and Block Interchange operations, and a PQ-tree is ...
Eden Ozeri +2 more
doaj +2 more sources
Heterogeneous rates of genome rearrangement contributed to the disparity of species richness in Ascomycota [PDF]
BMC Genomics, 2018 Background Chromosomal rearrangements have been shown to facilitate speciation through creating a barrier of gene flow. However, it is not known whether heterogeneous rates of chromosomal rearrangement at the genome scale contributed to the huge ...
Ahmad Rajeh, Jie Lv, Zhenguo Lin
doaj +2 more sources
GRSR: a tool for deriving genome rearrangement scenarios from multiple unichromosomal genome sequences [PDF]
BMC Bioinformatics, 2018 Background Genome rearrangements describe changes in the genetic linkage relationship of large chromosomal regions, involving reversals, transpositions, block interchanges, deletions, insertions, fissions, fusions and translocations etc.
Dan Wang, Lusheng Wang
doaj +2 more sources
A Novel Virus-Like Agent Originated From Genome Rearrangement of Porcine Circovirus Type 2 (PCV2) Enhances PCV2 Replication and Regulates Intracellular Redox Status In Vitro [PDF]
Frontiers in Cellular and Infection Microbiology, 2022 Genome rearrangement occurs to porcine circovirus type 2 (PCV2) during in vitro and in vivo infections, and a number of rearranged PCV2 genomes have been isolated and characterized. This study was conducted to investigate the role of the rearranged PCV2 (
Huicheng Feng +11 more
doaj +2 more sources
Analysis of local genome rearrangement improves resolution of ancestral genomic maps in plants [PDF]
BMC Genomics, 2020 Background Computationally inferred ancestral genomes play an important role in many areas of genome research. We present an improved workflow for the reconstruction from highly diverged genomes such as those of plants.
Diego P. Rubert +3 more
doaj +2 more sources
A Path-Deformation Framework for Determining Weighted Genome Rearrangement Distance [PDF]
Frontiers in Genetics, 2020 Measuring the distance between two bacterial genomes under the inversion process is usually done by assuming all inversions to occur with equal probability. Recently, an approach to calculating inversion distance using group theory was introduced, and is
Sangeeta Bhatia +5 more
doaj +2 more sources
Are there rearrangement hotspots in the human genome? [PDF]
PLoS Computational Biology, 2007 In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome.
Max A Alekseyev, Pavel A Pevzner
doaj +4 more sources
Deep ancestry of programmed genome rearrangement in lampreys [PDF]
Developmental Biology, 2017 Jeramiah Smith +2 more
exaly +2 more sources
Genome Rearrangement Shapes Prochlorococcus Ecological Adaptation [PDF]
Applied and Environmental Microbiology, 2018 Zeng Qinglu, Xilin Xiao, Nianzhi Jiao
exaly +2 more sources