Results 1 to 10 of about 1,163 (117)
Are there rearrangement hotspots in the human genome? [PDF]
PLoS Computational Biology, 2007 In a landmark paper, Nadeau and Taylor [18] formulated the random breakage model (RBM) of chromosome evolution that postulates that there are no rearrangement hotspots in the human genome.
Max A Alekseyev, Pavel A Pevzner
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Pathogens, 2021 The ability of Leptospirae to persist in environments and animal hosts but to cause clinically highly variable disease in humans has made leptospirosis the most common zoonotic disease.
Siti Roszilawati Ramli +8 more
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Rearrangement Events on Circular Genomes
Bulletin of Mathematical Biology, 2023 AbstractEarly literature on genome rearrangement modelling views the problem of computing evolutionary distances as an inherently combinatorial one. In particular, attention is given to estimating distances using the minimum number of events required to transform one genome into another.
Joshua Stevenson +2 more
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Finding local genome rearrangements [PDF]
Algorithms for Molecular Biology, 2018 The double cut and join (DCJ) model of genome rearrangement is well studied due to its mathematical simplicity and power to account for the many events that transform gene order. These studies have mostly been devoted to the understanding of minimum length scenarios transforming one genome into another. In this paper we search instead for rearrangement
Simonaitis, Pijus, Swenson, Krister
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G3: Genes, Genomes, Genetics, 2020 The aim of this study was to analyze the genomic homology between cattle (Bos taurus) and buffaloes (Bubalus bubalis) and to propose a rearrangement of the buffalo genome through linkage disequilibrium analyses of buffalo SNP markers referenced in the ...
Daniel Jordan de Abreu Santos +9 more
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progressiveMauve: multiple genome alignment with gene gain, loss and rearrangement. [PDF]
PLoS ONE, 2010 Multiple genome alignment remains a challenging problem. Effects of recombination including rearrangement, segmental duplication, gain, and loss can create a mosaic pattern of homology even among closely related organisms.We describe a new method to ...
Aaron E Darling, Bob Mau, Nicole T Perna
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Comparative genomics reveals insight into the evolutionary origin of massively scrambled genomes
eLife, 2022 Ciliates are microbial eukaryotes that undergo extensive programmed genome rearrangement, a natural genome editing process that converts long germline chromosomes into smaller gene-rich somatic chromosomes.
Yi Feng +6 more
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A New Algorithm for Identifying Genome Rearrangements in the Mammalian Evolution
Frontiers in Genetics, 2019 Genome rearrangements are the evolutionary events on level of genomes. It is a global view on evolution research of species to analyze the genome rearrangements.
Juan Wang +4 more
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Sorting Permutations by λ-Operations [PDF]
Journal of Universal Computer Science, 2019 For estimating the evolutionary distance between genomes of two different organisms, many sorting permutation problems have emerged. A well accepted way to do this is considering the smallest sequence of rearrangement events { mutations which affect ...
Guilherme Henrique Santos Miranda +2 more
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BMC Bioinformatics, 2018 Background Genome rearrangements describe changes in the genetic linkage relationship of large chromosomal regions, involving reversals, transpositions, block interchanges, deletions, insertions, fissions, fusions and translocations etc.
Dan Wang, Lusheng Wang
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