Results 311 to 320 of about 4,923,579 (336)

Carotenoids and genomic stability

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001
Epidemiological evidence abounds for a link between intake of carotenoids from fruit and vegetable foods and relatively low incidence of various cancers. However, intervention trials have shown, in some cases, a significant increase in occurrence of lung cancer in those volunteers taking supplements of beta-carotene.
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Genomic stability of gibbon oncornavirus

Journal of Virology, 1978
The 70S RNAs from several gibbon type C viruses were examined for sequence homology by molecular hybridization using complementary DNA probes. The sequence homology was found to vary with each virus isolate. The genome from one isolate was examined for genomic stability after the virus was experimentally passaged through three unrelated gibbons.
L, Sun, T G, Kawakami, S I, Matoba
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Vitamin E and genome stability

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001
Free radicals and reactive oxygen species (ROS) which are generated continuously cause mutagenic alterations resulting in cancer, aging and abnormalities in the nervous system. Accumulating evidence indicates that Vitamin E, the most potent lipid peroxyl radical scavenger, may reduce free radical induced chromosomal damages through inhibition of free ...
K J, Claycombe, S N, Meydani
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CRL4Cdt2: Coupling Genome Stability to Ubiquitination.

Trends in Cell Biology, 2020
The cullin-RING E3 ubiquitin ligase CRL4Cdt2 has emerged as a master regulator of genome stability, which targets key cell cycle proteins for proteolysis during S phase and after DNA damage.
Andreas Panagopoulos, S. Taraviras, H. Nishitani, Z. Lygerou   +3 more
semanticscholar   +1 more source

Telomere dynamics in genome stability

Trends in Biochemical Sciences, 2006
The past several years have seen an increasing interest in telomere recombinational interactions that provide many functions in telomere capping, in telomere size homeostasis and in overcoming the catastrophic effects of telomerase deficiency. Several key recombination mechanisms have emerged from recent investigations.
Mrinal K, Bhattacharyya, Arthur J, Lustig   +1 more
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Diet and Genomic Stability

2007
Cancer results from a disordered and unstable genome - the degree of abnormality progresses as the process of oncogenesis proceeds. Such genomic instability appears to be subject to control by environmental factors as evidenced by the number of cancers that are either caused by specific environmental agents (lung, skin, cervix) or else regulated by a ...
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Vitamin D and genomic stability

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001
1alpha,25-dihydroxyvitamin D(3) [1,25(OH)(2)D(3)] has been shown to act on novel target tissues not related to calcium homeostasis. There have been reports characterizing 1,25(OH)(2)D(3) receptors and activities in diverse tissues such as brain, pancreas, pituitary, skin, muscle, placenta, immune cells and parathyroid.
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Low power lasers on genomic stability

Journal of Photochemistry and Photobiology B: Biology, 2018
Exposure of cells to genotoxic agents causes modifications in DNA, resulting to alterations in the genome. To reduce genomic instability, cells have DNA damage responses in which DNA repair proteins remove these lesions. Excessive free radicals cause DNA damages, repaired by base excision repair and nucleotide excision repair pathways.
Larissa Alexsandra da Silva Neto, Trajano, Luiz Philippe da Silva, Sergio, Ana Carolina, Stumbo, Andre Luiz, Mencalha, Adenilson de Souza da, Fonseca   +4 more
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SWI/SNF: Complex complexes in genome stability and cancer.

DNA Repair, 2019
SWI/SNF complexes are among the most studied ATP-dependent chromatin remodeling complexes, mostly due to their critical role in coordinating chromatin architecture and gene expression.
C. Ribeiro-Silva, W. Vermeulen, H. Lans
semanticscholar   +1 more source

Vitamin C and genomic stability

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 2001
Vitamin C, a water-soluble glucose derivative, has considerable antioxidant activity in vitro, in part because of its ease of oxidation and because the semidehydroascorbate radical derived from it is of low reactivity. Vitamin C in vivo is an essential cofactor for a range of enzymes involved in diverse metabolic pathways, but much recent literature ...
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