Results 51 to 60 of about 4,923,579 (336)
Caloric restriction and genomic stability [PDF]
Nucleic Acids Research, 2007 Caloric restriction (CR) reduces the incidence and progression of spontaneous and induced tumors in laboratory rodents while increasing mean and maximum life spans. It has been suggested that CR extends longevity and reduces age-related pathologies by reducing the levels of DNA damage and mutations that accumulate with age.
Heydari, Ahmad R. +3 more
openaire +2 more sources
Cell ReportsR-loops are three-stranded structures that can pose threats to genome stability. RNase H1 precisely recognizes R-loops to drive their resolution within the genome, but the underlying mechanism is unclear.
Jun Zhang +14 more
semanticscholar +1 more source
DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.
Current Opinion in Genetics and Development, 2020 Mammalian cells have evolved multiple pathways to repair DNA double strand breaks (DSBs) and ensure genome stability. In addition to non-homologous end-joining (NHEJ) and homologous recombination (HR), cells evolved an error-prone repair pathway termed ...
Alessandra Brambati +2 more
semanticscholar +1 more source
Alternative splicing and genomic stability [PDF]
Physical Biology, 2004 6 ...
openaire +3 more sources
BAF180 Promotes Cohesion and Prevents Genome Instability and Aneuploidy
Cell Reports, 2014 BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking BAF180.
Peter M. Brownlee +4 more
doaj +1 more source
Molecular basis for DNA repair synthesis on short gaps by mycobacterial Primase-Polymerase C
Nature Communications, 2020 Mycobacteria Prim-PolC performs short gap synthesis following removal of lesions during excision repair. Here the authors resolve crystal structures of pre- and post-catalytic Prim-PolC complexes bound to gapped DNA substrates to define its mechanism.
Nigel C. Brissett +7 more
doaj +1 more source
Clinically Applicable Inhibitors Impacting Genome Stability [PDF]
Molecules, 2018 Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize the potential of truly personalised treatment options, we need targeted therapies that precisely disrupt the compensatory pathways ...
Anu Prakash +3 more
openaire +2 more sources
Delineation of two multi-invasion-induced rearrangement pathways that differently affect genome stability [PDF]
, 2023 Diedre Reitz +6 more
openalex +3 more sources
Specialized interfaces of Smc5/6 control hinge stability and DNA association
Nature Communications, 2017 Structural Maintenance of Chromosomes (SMC) complexes maintain genome integrity by regulating the segregation of chromosomes. Here, Altet al. describe the structure of the heterodimeric Smc5/6-hinge from fission yeast and define functional features ...
Aaron Alt +10 more
doaj +1 more source
Somatic PMK-1/p38 signaling links environmental stress to germ cell apoptosis and heritable euploidy
Nature Communications, 2022 Here the authors show that elimination of germ cells carrying damaged genomes is regulated by intestinal stress signalling in nematodes. Failure of the intestinal signalling results in stress-induced aneuploidy indicating that environmental stress ...
Najmeh Soltanmohammadi +2 more
doaj +1 more source