Results 81 to 90 of about 4,923,579 (336)

Mismatch repair: praying for genome stability [PDF]

Current Biology, 2001
Over the past years additional functions have emerged for mismatch repair proteins. The first was the involvement of mismatch repair proteins with homologous DNA recombination, one of the pathways that repair DNA double-strand breaks. A key intermediate in this repair process is heteroduplex joint formation between the ends of the broken molecule and ...
de Wind, Niels, Hays, John B.
openaire   +2 more sources

Structural basis of Fanconi anemia pathway activation by FANCM

The EMBO Journal
FANCM is crucial in genome maintenance, functioning in the Fanconi anemia (FA) pathway, alternative lengthening of telomeres (ALT), and replication fork protection.
Rohan Bythell-Douglas, Sylvie van Twest, Lara Abbouche, Elyse Dunn, Rachel J Coulthard, David C Briggs, Vincent Murphy, Xinxin Zhang, Winnie Tan, Sarah S Henrikus, Dongming Qian, Yin Wu, Jana Wolf, Laurent Rigoreau, Shabih Shakeel, Kathryn L Chapman, Neil Q McDonald, Andrew J Deans   +17 more
doaj   +1 more source

Characterisation of a stably integrated expression system for exogenous protein expression in DT40 [version 1; referees: 2 approved, 1 approved with reservations]

Wellcome Open Research, 2017
The use of constitutive promoters to drive exogenous protein expression is an important tool for the study of diverse biological processes. To create and characterise a stably integrated expression system for DT40 cells, we constructed integration ...
Meliti Skouteri, Helfrid Hochegger, Antony M. Carr   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

DNA Repair, Genome Stability, and Aging [PDF]

Cell, 2005
Aging can be defined as progressive functional decline and increasing mortality over time. Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates with age, and DNA repair defects can cause phenotypes resembling premature aging. We discuss how cellular DNA damage responses may contribute to manifestations of aging.
Lombard, David B., Chua, Katrin F., Mostoslavsky, Raul, Franco, Sonia, Gostissa, Monica, Alt, Frederick W.   +5 more
openaire   +2 more sources

Molecular Basis for DNA Double-Strand Break Annealing and Primer Extension by an NHEJ DNA Polymerase

Cell Reports, 2013
Nonhomologous end-joining (NHEJ) is one of the major DNA double-strand break (DSB) repair pathways. The mechanisms by which breaks are competently brought together and extended during NHEJ is poorly understood.
Nigel C. Brissett, Maria J. Martin, Edward J. Bartlett, Julie Bianchi, Luis Blanco, Aidan J. Doherty   +5 more
doaj   +1 more source

White shark genome reveals ancient elasmobranch adaptations associated with wound healing and the maintenance of genome stability

Proceedings of the National Academy of Sciences of the United States of America, 2019
Significance Sharks represent an ancient vertebrate lineage whose genomes have been only minimally investigated. We here characterize the genome of the white shark, an apex marine predator.
Nicholas J Marra, M. Stanhope, N. Jue, Minghui Wang, Qi Sun, Paulina D Pavinski Bitar, V. P. Richards, A. Komissarov, M. Rayko, S. Kliver, Bryce J. Stanhope, Chuck Winkler, S. O’Brien, A. Antunes, S. Jorgensen, M. Shivji   +15 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Monoubiquitination by the human Fanconi anemia core complex clamps FANCI:FANCD2 on DNA in filamentous arrays

eLife, 2020
FANCI:FANCD2 monoubiquitination is a critical event for replication fork stabilization by the Fanconi anemia (FA) DNA repair pathway. It has been proposed that at stalled replication forks, monoubiquitinated-FANCD2 serves to recruit DNA repair proteins ...
Winnie Tan, Sylvie van Twest, Andrew Leis, Rohan Bythell-Douglas, Vincent J Murphy, Michael Sharp, Michael W Parker, Wayne Crismani, Andrew J Deans   +8 more
doaj   +1 more source

Elongation Factor TFIIS Prevents Transcription Stress and R-Loop Accumulation to Maintain Genome Stability

Molecules and Cells, 2019
Summary Although correlations between RNA polymerase II (RNAPII) transcription stress, R-loops, and genome instability have been established, the mechanisms underlying these connections remain poorly understood.
D. Zatreanu, Zhong Han, R. Mitter, E. Tumini, H. Williams, Lea Gregersen, A. B. Dirac-Svejstrup, Stefania Roma, A. Stewart, A. Aguilera, J. Svejstrup   +10 more
semanticscholar   +1 more source