Genome wide association study gwas

Results 191 to 200 of about 121,324 (217)

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang +12 more
wiley +1 more source

Yoruba Moral Philosophy and the Ethical Governance of Data Science Health Research in Africa

Developing World Bioethics, EarlyView.
ABSTRACT Data science health research (DSHR) which encompasses genomic biobanking, algorithmic clinical prediction, large‐scale secondary use of health data, and AI‐assisted diagnostics is expanding rapidly across Africa through initiatives such as the Human Heredity and Health in Africa (H3Africa) consortium and the Data Science for Health Discovery ...
Clement Adebamowo +11 more
wiley +1 more source

Liver Fibrosis and IRS1 rs2972146 Are Associated With Weight Loss Response After Metabolic Bariatric Surgery

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background and Aims Weight loss after metabolic bariatric surgery (MBS) is heterogeneous, and the contribution of liver histology and genetic susceptibility to insufficient weight loss (IWL) or weight regain (WR) remains unclear. We assessed the prevalence of IWL and WR after MBS and their association with liver histology and metabolic ...
Felice Cinque +18 more
wiley +1 more source

Genetically Proxied GIP‐GIPR Pathway Perturbation and Fracture Risk

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To determine whether genetic proxies for incretin pathway perturbation are associated with fracture risk and bone mineral density, providing human genetic evidence relevant to the skeletal safety of incretin‐based therapies. Materials and Methods We conducted drug‐target Mendelian randomisation using cis genetic variants near GIP, GIPR ...
Wenjie Cheng +5 more
wiley +1 more source

Multi-Trait GWAS Analyses of Blood Pressure Traits Provide Limited Gains in Locus Discovery or Polygenic Risk Score Performance Compared to Single-Trait GWAS. [PDF]