Results 141 to 150 of about 2,173,654 (348)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Morpho-Molecular and Genomic Characterization of Penicillium mexicanum Isolates Retrieved from a Forsaken Gold Mine

Applied Sciences
During the ongoing studies designed to examine the fungal diversity present within the abandoned and flooded Escádia Grande gold mine (Góis, Portugal), we repeatedly isolated several specimens belonging to a Penicillium species.
João Trovão, Fabiana Soares, Diana Sofia Paiva, António Portugal   +3 more
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Co-opted and canonical glycerol channels play a major role during anhydrobiosis of an extremophile crustacean

BMC Biology
Background Extremophiles evolved capacities to survive extended exposure to harsh environmental conditions such as complete desiccation (anhydrobiosis) and freezing (cryobiosis).
Ángel Rey-Alfonso, José Luis Maestro, François Chauvigné, Jèssica Gómez-Garrido, Tyler Alioto, Peter Bossier, Roderick Nigel Finn, Joan Cerdà   +7 more
doaj   +1 more source

Lactic Acid Bacteria in Chinese Sauerkraut: Its Isolation and In Vitro Probiotic Properties

Foods
Probiotics have been widely explored for their potential in managing hyperuricemia. However, their isolation and identification are fundamental prerequisites for practical application.
Ming-Yang Han, Wen-Yong Lou, Meng-Fan Li
doaj   +1 more source

Genomic analysis in personalized diagnostics

, 2017

openalex   +2 more sources

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

4DNvestigator: time series genomic data analysis toolbox

, 2021
Stephen Lindsly, Can Chen, Sijia Liu, Scott Ronquist, Samuel Dilworth, Michael D. Perlman, Indika Rajapakse   +6 more
openalex   +3 more sources

Senataxin regulates cisplatin resistance through an R-loop-mediated mechanism in HPV-associated head and neck cancer

iScience
Summary: Resistance to cisplatin is a key clinical concern in HPV-independent (HPV−) and HPV-associated (HPV+) head and neck cancer. Upregulation of DNA repair is known to contribute to cisplatin resistance and a major source of endogenous DNA damage are
Hannah Crane, Ian Carr, Keith D. Hunter, Sherif F. El-Khamisy   +3 more
doaj   +1 more source

Additional file 15: of Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene

, 2019
Simon Lalonde, Valérie-Anne Codina-Fauteux, Sébastian Bellefon, Francis Leblanc, Mélissa Beaudoin, Marie-Michelle Simon, Rola Dali, Tony Kwan, Ken Sin Lo, Tomi Pastinen, Guillaume Lettre   +10 more
openalex   +1 more source