Results 241 to 250 of about 2,173,654 (348)

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Integrative genomic analysis reveals DHX58 as a key player in gastric cancer. [PDF]

PLoS One
Li Y, Zhang L, Wen Z, Wang H, Zhang K, Wang B, Li J, Kang H, Gao Y, Yu Z, Du Y.   +10 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Genomic Analysis of Doxycycline Resistance-Associated 16S rRNA Mutations in Treponema pallidum Subspecies pallidum. [PDF]

Emerg Infect Dis
Long GS, Neale M, Braukmann T, Tran V, Singh N, Allen V, Morshed M, Minion J, Van Caeseele P, Vallée M, Hatchette T, Patel SN, Tsang RSW, Duvvuri VR.   +13 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Genomic analysis reveals convergent signatures of selection for milk traits in sheep and goats. [PDF]

J Anim Sci Biotechnol
Akhatayeva Z, Shi Y, Dossybayev K, Malmakov N, Cheng H, Baatar N, Yang J, Li M, Lin K, Xu S.   +9 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Transmission of carbapenemase-producing Enterobacter in Ontario, Canada: a retrospective genomic analysis. [PDF]

Emerg Microbes Infect
Izydorczyk C, Lee R, Mataseje L, Golding GR, Edge TA, Boyd R, Braukmann T, Carroll A, Katz K, Kozak R, Jamal AJ, MacFadden DR, Mazzulli T, Melano R, Mubareka S, Patel S, Poutanen SM, Richardson D, Waglechner N, McGeer A, Toronto Invasive Bacterial Diseases Network.   +20 more
europepmc   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Acquired antimicrobial resistance genes in Bordetella Species: a global genomic analysis. [PDF]

J Antimicrob Chemother
Tang B, Hu X, Song Y, Liu X, Zhao G, Yue M.   +5 more
europepmc   +1 more source