Results 231 to 240 of about 2,173,654 (348)

Genomic analysis unlocks the potential of denosumab as a targeted therapy for Crohn's disease. [PDF]

Sci Rep
Pranata R, Ratnasari N, Bayupurnama P, Indrarti F, Aulia N, Rahmawati H, Adikusuma W, Mugiyanto E, Irham LM, Gunarto C, Alya SS, Hadi VF, Sentosa GC, Wahyuningsih AT, Lin CF, Satria RD.   +15 more
europepmc   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China. [PDF]

BMC Genomics
Liu Z, Wang Q, Wang W, Ding J, Lv P, Jiang Y, Wang X, Liu Y, Zhang C, Zhang C, Luo L, Zhou Y, Xu X, Chen M.   +13 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Integrative genomic analysis identifies key target genes and candidate drugs for spinal stenosis. [PDF]

Front Mol Neurosci
Xia D, Chen Y, Wu R, Tang Y, Sun Y, Chen X.   +5 more
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Expanding access to genomic analysis and reporting in research studies: The GENYSIS research core. [PDF]

J Clin Transl Sci
Foss KS, Sneddon TP, Fensterle EP, Melville SA, Xiong M, Gregory CW, Greenwood P, Rafferty KA, Hutchins EK, Vora NL, Gilmore KL, Hunter SE, Weck KE, Berg JS, Powell BC.   +14 more
europepmc   +1 more source

Intercompartmental communication in senescence

FEBS Open Bio, EarlyView.
Senescent cells experience structural changes in the plasma membrane, endoplasmic reticulum, mitochondria, lysosomes, nucleus, and cytoskeleton. These alterations disrupt crosstalk among cellular compartments, impairing vesicular trafficking, contact sites, and molecular flow.
Krystyna Mazan‐Mamczarz, Eleanor J. Wind, Jixiang Leng, Myriam Gorospe   +3 more
wiley   +1 more source

Integrative Genomic Analysis Identifies MAGT1 as a Key Regulator of Proliferation and Poor Prognosis in Breast Cancer. [PDF]

Hum Mutat
Zhao L, Song Z.
europepmc   +1 more source