Results 61 to 70 of about 48,815 (295)

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Imputation of genotypes from low- to high-density genotyping platforms and implications for genomic selection

, 2011
peer-reviewedThe objective of this study was to quantify the accuracy achievable from imputing genotypes from a commercially available low-density marker panel (2730 single nucleotide polymorphisms (SNPs) following edits) to a commercially available ...
J.F. Kearney, Kearney, J.F., D.P. Berry, Berry, Donagh   +3 more
core   +1 more source

Genetics of animal health and disease in cattle [PDF]

, 2011
peer-reviewedThere have been considerable recent advancements in animal breeding and genetics relevant to disease control in cattle, which can now be utilised as part of an overall programme for improved cattle health.
Bermingham Mairead L, Margaret Good, Berry, D.P., More Simon J, Bermingham, M.L., Berry Donagh P, Berry, Donagh P., Good, Margaret, Good Margaret, Donagh P Berry, Bermingham, Mairead L, Good, M., More, S.J., Bermingham, Mairead L., More, Simon J, Simon J More, Mairead L Bermingham, et al., Berry, Donagh   +18 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Improvement of Genomic Predictions in Small Breeds by Construction of Genomic Relationship Matrix Through Variable Selection

Frontiers in Genetics, 2022
Genomic selection has been increasingly implemented in the animal breeding industry, and it is becoming a routine method in many livestock breeding contexts.
Enrico Mancin, Lucio Flavio Macedo Mota, Beniamino Tuliozi, Rina Verdiglione, Roberto Mantovani, Cristina Sartori   +5 more
doaj   +1 more source

Genomic selection for growth traits in Pacific oyster (Crassostrea gigas): Potential of low-density marker panels for breeding value prediction [PDF]

, 2018
Pacific oysters are a key aquaculture species globally, and genetic improvement via selective breeding is a major target. Genomic selection has the potential to expedite genetic gain for key target traits of a breeding program, but has not yet been ...
Matika, Oswald, Oswald Matika (561285), Alejandro P. Gutierrez, Gutierrez, Alejandro P, Gutierrez Silva, Alejandro, Houston, Ross D, Houston, Ross, Tim P. Bean (453620), Tim P. Bean, Ross D. Houston, Ross D. Houston (438814), Alejandro P. Gutierrez (700392), Matika, Oswald; id_orcid, Oswald Matika, Bean, Tim P   +14 more
core   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Recent progress in alfalfa (Medicago sativa L.) genomics and genomic selection

Crop Journal, 2018
Alfalfa (M. sativa L.) is a highly valuable forage crop, providing >58 Mt of hay, silage, and pasture each year in the United States. As alfalfa is an outcrossing autotetraploid crop, however, breeding for enhanced agronomic traits is challenging and ...
Charles Hawkins, Long-Xi Yu
doaj   +1 more source

Potential of preimplantation genomic selection for carcass traits in Japanese Black cattle

The Journal of Reproduction and Development, 2019
Preimplantation genomic selection using genomic estimated breeding values (GEBVs) based on single nucleotide polymorphism (SNP) genotypes is expected to accelerate genetic improvement in cattle.
Takashi FUJII, Akira NAITO, Hiroki HIRAYAMA, Masashi KASHIMA, Hitomi YOSHINO, Takeshi HANAMURE, Yukio DOMON, Hiroyuki HAYAKAWA, Toshio WATANABE, Satoru MORIYASU, Soichi KAGEYAMA   +10 more
doaj   +1 more source