Results 81 to 90 of about 48,815 (295)

Genomic breeding value estimation using genetic markers, inferred ancestral haplotypes, and the genomic relationship matrix [PDF]

Journal of Dairy Science, 2011
With the introduction of new single nucleotide polymorphism (SNP) chips of various densities, more and more genotype data sets will include animals genotyped for only a subset of the SNP. Imputation techniques based on unobserved ancestral haplotypes may be used to infer missing genotypes.
de Roos, A. P. W., Schrooten, C., Druet, Tom   +2 more
openaire   +3 more sources

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Impact of reduced marker set estimation of genomic relationship matrices on genomic selection for feed efficiency in Angus cattle

BMC Genetics, 2010
Background Molecular estimates of breeding value are expected to increase selection response due to improvements in the accuracy of selection and a reduction in generation interval, particularly for traits that are difficult or expensive to record or are
Northcutt Sally L, McClure Matthew C, McKay Stephanie D, Schnabel Robert D, Taylor Jeremy F, Rolf Megan M, Kerley Monty S, Weaber Robert L   +7 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Comparison of genomic predictions for carcass and reproduction traits in Berkshire, Duroc and Yorkshire populations in Korea [PDF]

Asian-Australasian Journal of Animal Sciences, 2019
Objective A genome-based best linear unbiased prediction (GBLUP) method was applied to evaluate accuracies of genomic estimated breeding value (GEBV) of carcass and reproductive traits in Berkshire, Duroc and Yorkshire populations in Korean swine ...
Asif Iqbal, Tae-Jeong Choi, You-Sam Kim, Yun-Mi Lee, M. Zahangir Alam, Jong-Hyun Jung, Ho-Sung Choe, Jong-Joo Kim   +7 more
doaj   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Development of genomic predictions for harvest and carcass weight in channel catfish

Genetics Selection Evolution, 2018
Background Catfish farming is the largest segment of US aquaculture and research is ongoing to improve production efficiency, including genetic selection programs to improve economically important traits.
Andre L. S. Garcia, Brian Bosworth, Geoffrey Waldbieser, Ignacy Misztal, Shogo Tsuruta, Daniela A. L. Lourenco   +5 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Single-Step BLUP with Varying Genotyping Effort in Open-Pollinated Picea glauca

G3: Genes, Genomes, Genetics, 2017
Maximization of genetic gain in forest tree breeding programs is contingent on the accuracy of the predicted breeding values and precision of the estimated genetic parameters.
Blaise Ratcliffe, Omnia Gamal El-Dien, Eduardo P. Cappa, Ilga Porth, Jaroslav Klápště, Charles Chen, Yousry A. El-Kassaby   +6 more
doaj   +1 more source

Accuracy of Estimation of Genomic Breeding Values in Pigs Using Low-Density Genotypes and Imputation [PDF]

G3 Genes|Genomes|Genetics, 2014
Abstract Genomic selection has the potential to increase genetic progress. Genotype imputation of high-density single-nucleotide polymorphism (SNP) genotypes can improve the cost efficiency of genomic breeding value (GEBV) prediction for pig breeding.
Badke, Yvonne M., Bates, Ronald O., Ernst, Catherine W., Fix, Justin, Steibel, Juan P.   +4 more
openaire   +2 more sources