Results 101 to 110 of about 56,311 (230)
Long noncoding RNA functionality in imprinted domain regulation.
PLoS Genetics, 2020 Genomic imprinting is a parent-of-origin dependent phenomenon that restricts transcription to predominantly one parental allele. Since the discovery of the first long noncoding RNA (lncRNA), which notably was an imprinted lncRNA, a body of knowledge has ...
William A MacDonald, Mellissa R W Mann
doaj +1 more source
Exercise epigenetics and the foetal origins of disease [PDF]
, 2014 Exercise epigenetics is a nascent area of research with vast health implications (e.g., from the treatment of obesity-related diseases to beneficially decoupling epigenetic and chronological age).
Dale E, Thomas EW Chalk, William M Brown
core +1 more source
Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression
The FEBS Journal, EarlyView.T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera +5 more
wiley +1 more source
Cell Reports, 2015 Genomic imprinting depends on the establishment and maintenance of DNA methylation at imprinting control regions. However, the mechanisms by which these heritable marks influence allele-specific expression are not fully understood. By analyzing maternal,
Katherine A. Alexander +4 more
doaj +1 more source
Genetic Evaluation of Beef Sires Using a Beef‐on‐Dairy Crossbred Reference Population
Journal of Animal Breeding and Genetics, EarlyView.ABSTRACT In recent years, Beef‐on‐Dairy (BoD) crossbreeding programs have gained momentum to enhance dairy cattle's economic and genetic merits while meeting the demand for high‐quality beef. However, bulls with superior growth potential can lead to calving problems; thus, Holstein dairy farmers must decide which semen to use to avoid calving problems ...
Julius Mugambe +4 more
wiley +1 more source
Parent-of-origin effects cause genetic variation in pig performance traits [PDF]
, 2017 In order to assess the relative importance of genomic imprinting for the genetic variation of traits economically relevant for pork production, a data set containing 21 209 records from Large White pigs was analysed.
Luther, H., Neugebauer, N., Reinsch, N.
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Practitioner Review: Infant mental health meets cell and molecular biology – a look to the future
Journal of Child Psychology and Psychiatry, EarlyView.Background A major research effort in the past two decades has begun to illuminate how experience ‘gets under the skin’ – that is – the cellular and molecular processes that are associated with adversity and resilience. Methods We selectively review three areas of this research: epigenetics, especially DNA methylation, telomere length, and inflammatory
Charles H. Zeanah +3 more
wiley +1 more source
Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
eLife, 2015 The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic imprinting in the
Julio D Perez +10 more
doaj +1 more source
A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome. [PDF]
, 2019 BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder that is caused by maternal genetic deficiency of a gene that encodes E6-AP ubiquitin-protein ligase (gene symbol UBE3A) mapping to chromosome 15q11-q13.
Anselm, Irina +8 more
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