Results 81 to 90 of about 24,778 (138)
Methods of epigenome editing for probing the function of genomic imprinting [PDF]
, 2016 The curious patterns of imprinted gene expression draw interest from several scientific disciplines to the functional consequences of genomic imprinting.
Hill, Matthew +2 more
core +1 more source
A placebo-controlled trial of folic acid and betaine in identical twins with Angelman syndrome. [PDF]
, 2019 BackgroundAngelman syndrome (AS) is a neurodevelopmental disorder that is caused by maternal genetic deficiency of a gene that encodes E6-AP ubiquitin-protein ligase (gene symbol UBE3A) mapping to chromosome 15q11-q13.
Anselm, Irina +8 more
core
Cell Reports, 2015 Genomic imprinting depends on the establishment and maintenance of DNA methylation at imprinting control regions. However, the mechanisms by which these heritable marks influence allele-specific expression are not fully understood. By analyzing maternal,
Katherine A. Alexander +4 more
doaj +1 more source
Identification of CpG islands using a bank of IIR lowpass filters [PDF]
, 2004 It has been known that biological sequences such as the DNA sequence display different kinds of patterns depending on their biological functions. This statistical difference can be exploited for identifying the region of interest, such as the protein ...
Vaidyanathan, P. P., Yoon, Byung-Jun
core
Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
eLife, 2015 The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic imprinting in the
Julio D Perez +10 more
doaj +1 more source
DNA methylation profiling of the human major histocompatibility complex: A pilot study for the Human Epigenome Project [PDF]
, 2004 The Human Epigenome Project aims to identify, catalogue, and interpret genome-wide DNA methylation phenomena. Occurring naturally on cytosine bases at cytosine-guanine dinucleotides, DNA methylation is intimately involved in diverse biological processes ...
Andrews, TD +13 more
core
Resonance, 2000 A review with 4 refs. The authors discuss a few examples that illustrate the drastic effects that genome imprinting can have on the phenotypes of progeny. There are at least a few genes whose phenotypic expression depends upon the parent from which they have been inherited.
Ranganath, H. A., Tanuja, M. T.
openaire +1 more source
The Emerging Role of Ten-Eleven Translocation 1 in Epigenetic Responses to Environmental Exposures. [PDF]
, 2020 Mounting evidence from epidemiological studies and animal models has linked exposures to environmental factors to changes in epigenetic markers, especially in DNA methylation.
Brown, Anthony P, Ji, Hong, Zhu, Tao
core
A maternal-offspring coadaptation theory for the evolution of genomic imprinting.
PLoS Biology, 2006 Imprinted genes are expressed either from the maternally or paternally inherited copy only, and they play a key role in regulating complex biological processes, including offspring development and mother-offspring interactions.
Jason B Wolf, Reinmar Hager
doaj +1 more source