Results 81 to 90 of about 33,268 (235)
Genetic epilepsies with myoclonic seizures: Mechanisms and syndromes
Epilepsia Open, EarlyView.Abstract Genetic epilepsy with myoclonic seizures encompasses a heterogeneous spectrum of conditions, ranging from benign and self‐limiting forms to severe, progressive disorders. While their causes are diverse, a significant proportion stems from genetic abnormalities.
Antonietta Coppola +3 more
wiley +1 more source
Cell Reports, 2015 Genomic imprinting depends on the establishment and maintenance of DNA methylation at imprinting control regions. However, the mechanisms by which these heritable marks influence allele-specific expression are not fully understood. By analyzing maternal,
Katherine A. Alexander +4 more
doaj +1 more source
Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing
Exploration, EarlyView.This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang +8 more
wiley +1 more source
Quantitative and functional interrogation of parent-of-origin allelic expression biases in the brain
eLife, 2015 The maternal and paternal genomes play different roles in mammalian brains as a result of genomic imprinting, an epigenetic regulation leading to differential expression of the parental alleles of some genes. Here we investigate genomic imprinting in the
Julio D Perez +10 more
doaj +1 more source
International Journal of Cancer, EarlyView.ABSTRACT Wilms Tumour (WT), the most common kidney cancer in children, presents features of altered kidney development and frequently exhibits molecular alterations at the 11p15.5 imprinted locus, affecting the IGF2 and H19 genes, which contribute to tumour growth and predisposition.
Abu Saadat +14 more
wiley +1 more source
Genomic Imprinting and Sex Allocation
The American Naturalist, 2009 Genomic imprinting allows maternally and paternally derived alleles to have different patterns of expression (one allele is often silent). Kin selection provides an explanation of genomic imprinting because conflicts of interest can arise between paternally and maternally inherited alleles when they have different probabilities of being present in ...
Geoff Wild, Stuart A. West
openaire +3 more sources
iMetaOmics, EarlyView.The gut–mammary axis integrates intestinal health with mammary function through neural, endocrine, and immune pathways. Nutritional interventions (probiotics, prebiotics, metabolites) improve gut microecology, generating microbial signals that travel via the axis to the mammary gland. There, they relieve inflammation, enhance milk quality and lactation,
Aolong Zhou +29 more
wiley +1 more source
iMetaOmics, EarlyView.Biological age provides a translational endpoint linking modifiable lifestyle behaviors—physical activity, sleep, and diet—to multi‐omics changes and downstream clinical outcomes. Integrating multiple ageing clocks with inflammatory, metabolic, and oxidative pathways supports reproducible, intervention‐ready strategies to slow ageing and extend ...
Yanwei You +9 more
wiley +1 more source
iMeta, EarlyView.Microbiome age (MA) has emerged as an innovative biomarker of biological aging, reflecting host aging trajectories through dynamic alterations in microbial composition, function, and host–microbe interactions across multiple body ecosystems. Diverse computational strategies—including traditional machine learning, deep learning, and multi‐omics ...
Zhexin Ni +26 more
wiley +1 more source