Results 101 to 110 of about 33,268 (235)

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

Phylogenetic and ecological duality in the otoliths of Sciaenidae

Cladistics, EarlyView.
Abstract Teleost fishes have evolved taxon‐specific otoliths that vary greatly in size and shape and are primarily involved in hearing and balance. This study identifies the main drivers of otolith shape disparity in Sciaenidae, a clade of sound‐producing bony fishes, using three‐dimensional geometric morphometrics (3DGM).
Dominique Mediodia, Roland B. Sookias, Valentin Fischer, Chien‐Hsiang Lin   +3 more
wiley   +1 more source

Counteracting selective pressures: Museum collections show declining Aglais io wing size

Ecological Entomology, EarlyView.
Using museum specimens, we found that forewing and hindwing length of Aglais io declined significantly between 1953 and 1984 across three north‐western German populations. The observed long‐term reduction in wing size in Aglais io is potentially linked to environmental change, with consistent patterns across all studied localities.
Hilke Hollens‐Kuhr, Sascha Buchholz
wiley   +1 more source

Homologous recombination mutants cause differing lethality between h− and h+ Schizosaccharomyces pombe strains due to mat1 heterochromatin

The FEBS Journal, EarlyView.
Homologous recombination (HR) in Schizosaccharomyces pombe is essential when mating‐type switching–induced double‐strand breaks (DSBs) form at the mat1 locus. In h90 and h− strains, efficient mat1 DSB formation renders HR indispensable unless suppressors block these breaks.
Peter Kolesar, Siarhei Paliavoi, Barbora Stefanovie, Jan Josef Palecek   +3 more
wiley   +1 more source

Chd4 and ThPOK cooperate to preserve structural and electrophysiological integrity of the adult heart through Sprr1a repression

The FEBS Journal, EarlyView.
Chd4/NuRD and ThPOK cooperate to maintain transcriptional repression and nuclear organization in adult cardiomyocytes. Chd4 loss reduces miR‐150‐5p, relieving repression of Sprr1a, while ThPOK loss further enhances Sprr1a activation, possibly through altered chromatin–lamina interactions.
Fadoua El Abdellaoui‐Soussi, Apolonia Novillo, Rocío Brea, Marta Ysbert, Lorena Cussó, Gonzalo Pizarro‐Sánchez, Manuel Desco, Iván Hernández, Ángel Luis Armesilla, Ignacio Pérez de Castro, Alicia R. Folgueras, Juan Miguel Redondo, Pablo Gómez‐del Arco   +12 more
wiley   +1 more source

Contribution of endosomal proteins EHD1 and EHD4 to the HIV‐1 replication cycle

The FEBS Journal, EarlyView.
EHD1 and EHD4, two key trafficking proteins, regulate multiple stages of HIV‐1 infection: In producer cells, they help produce fully infectious virus particles, regulate Envelope protein incorporation in a cell‐type‐dependent manner, and limit the accumulation of antiviral IFITM proteins in virions.
Grégory Pacini, Konstantinos Poalas, Margaux Versapuech, Clarisse Berlioz‐Torrent, Katy Janvier   +4 more
wiley   +1 more source

Epigenetic control and genomic imprinting dynamics of the Dlk1-Dio3 domain. [PDF]

Front Cell Dev Biol, 2023
Weinberg-Shukron A, Youngson NA, Ferguson-Smith AC, Edwards CA.   +3 more
europepmc   +1 more source

Childhood internalising symptoms at ages 3 and 6: a meta‐analysis of epigenome‐wide associations from cord and peripheral blood

Journal of Child Psychology and Psychiatry, EarlyView.
Background Pre‐ and postpartum environments and genetic effects influence childhood internalising problems, which increase depression risk. DNA methylation (DNAm) may capture some of these effects. We therefore investigated associations between child blood DNAm and internalising problems.
Laura Schellhas, Mannan Luo, Janine F. Felix, Christian M. Page, Mona Bekkhus, Marcus R. Munafò, Luisa Zuccolo, Alexandra Havdahl, Charlotte A.M. Cecil, Gemma C. Sharp   +9 more
wiley   +1 more source

Contrasting population genetic structures of congeneric coastal flounders associated with different early life histories

Journal of Fish Biology, EarlyView.
Abstract Marine fish species are likely to exhibit little genetic differentiation among populations due to their high dispersal potential during early life stages and migratory nature. However, recent studies have increasingly reported intraspecific genetic differentiation resulting from species‐specific ecological traits, environmental factors, and ...
Yuki Yamamoto, Hiroyuki Togashi, Yutaka Kurita, Satoshi Katayama, Yoshiaki Akaba, Mitsuhiro Ishii, Tatsuya Isshiki, Minoru Ikeda   +7 more
wiley   +1 more source