Results 1 to 10 of about 4,395,934 (279)

Evaluating the Consistency of Gene Methylation in Liver Cancer Using Bisulfite Sequencing Data

Frontiers in Cell and Developmental Biology, 2021
Bisulfite sequencing is considered as the gold standard approach for measuring DNA methylation, which acts as a pivotal part in regulating a variety of biological processes without changes in DNA sequences. In this study, we introduced the most prevalent
Xubin Zheng, Xubin Zheng, Qiong Wu, Qiong Wu, Haonan Wu, Kwong-Sak Leung, Man-Hon Wong, Xueyan Liu, Lixin Cheng   +8 more
doaj   +1 more source

Changes of DNA Methylation Pattern in Metabolic Pathways Induced by High-Carbohydrate Diet Contribute to Hyperglycemia and Fat Deposition in Grass Carp (Ctenopharyngodon idellus)

Frontiers in Endocrinology, 2020
Although studies have determined that epigenetics plays an essential role in regulating metabolism in mammals, research on nutrition-related DNA methylation remains to be lacking in teleosts.
Wen-Jing Cai, Wen-Jing Cai, Xu-Fang Liang, Xu-Fang Liang, Xiao-Chen Yuan, Xiao-Chen Yuan, Ai-Xuan Li, Ai-Xuan Li, Shan He, Shan He   +9 more
doaj   +1 more source

Integrative analysis of methylomic and transcriptomic data in fetal sheep muscle tissues in response to maternal diet during pregnancy

BMC Genomics, 2018
Background Numerous studies have established a link between maternal diet and the physiological and metabolic phenotypes of their offspring. In previous studies in sheep, we demonstrated that different maternal diets altered the transcriptome of fetal ...
Hadjer Namous, Francisco Peñagaricano, Marcello Del Corvo, Emanuele Capra, David L. Thomas, Alessandra Stella, John L. Williams, Paolo Ajmone Marsan, Hasan Khatib   +8 more
doaj   +1 more source

Identification of new differentially methylated genes that have potential functional consequences in prostate cancer. [PDF]

PLoS ONE, 2012
Many differentially methylated genes have been identified in prostate cancer (PCa), primarily using candidate gene-based assays. Recently, several global DNA methylation profiles have been reported in PCa, however, each of these has weaknesses in terms ...
Jin W Kim, Seong-Tae Kim, Aubrey R Turner, Tracey Young, Shelly Smith, Wennuan Liu, Johan Lindberg, Lars Egevad, Henrik Gronberg, William B Isaacs, Jianfeng Xu   +10 more
doaj   +1 more source

MethCP: Differentially Methylated Region Detection with Change Point Models

bioRxiv, 2018
Whole-genome bisulfite sequencing (WGBS) provides a precise measure of methylation across the genome, yet presents a challenge in identifying differentially methylated regions (DMRs) between different conditions.
Boying Gong, E. Purdom
semanticscholar   +1 more source

Characterization of Global DNA Methylation in Different Gene Regions Reveals Candidate Biomarkers in Pigs with High and Low Levels of Boar Taint

Veterinary Sciences, 2020
DNA methylation of different gene components, including different exons and introns, or different lengths of exons and introns is associated with differences in gene expression.
Xiao Wang, Haja N. Kadarmideen
doaj   +1 more source

Patients with PWS and related syndromes display differentially methylated regions involved in neurodevelopmental and nutritional trajectory

Clinical Epigenetics, 2021
Background Prader–Willi syndrome is a rare genetic neurodevelopmental disorder caused by a paternal deficiency of maternally imprinted gene expression located in the chromosome 15q11–q13 region.
J. Salles, S. Eddiry, E. Lacassagne, V. Laurier, C. Molinas, E. Bieth, N. Franchitto, J. Salles, M. Tauber   +8 more
semanticscholar   +1 more source

Simulated Wildfire Smoke Significantly Alters Sperm DNA Methylation Patterns in a Murine Model

Toxics, 2021
Wildfires are now a common feature of the western US, increasing in both intensity and number of acres burned over the last three decades. The effects of this changing wildfire and smoke landscape are a critical public and occupational health issue ...
Adam Schuller, Chiara Bellini, Timothy G. Jenkins, Matthew Eden, Jacqueline Matz, Jessica Oakes, Luke Montrose   +6 more
doaj   +1 more source

The differentially DNA-methylated region responsible for expression of runt-related transcription factor 2

Journal of Veterinary Medical Science, 2016
Runt-related transcription factor 2 (Runx2) is essential for osteogenesis. This study aimes at identification of the genomic region differentially methylated in DNA for regulation of Runx2 expression.
S. Wakitani, Daigo Yokoi, Y. Hidaka, Koichiro Nishino   +3 more
semanticscholar   +1 more source

Genome-wide differences in DNA methylation changes in caprine ovaries between oestrous and dioestrous phases

Journal of Animal Science and Biotechnology, 2018
Background DNA methylation plays a vital role in reproduction. Entire genome DNA methylation changes during the oestrous phase (ES) and dioestrous phase (DS) in the ovaries of Guanzhong dairy goats were investigated using bisulphite sequencing to ...
Xiaopeng An, Haidong Ma, Peng Han, Chao Zhu, Binyun Cao, Yueyu Bai   +5 more
doaj   +1 more source