Results 21 to 30 of about 4,395,934 (279)

Increased methylation at differentially methylated region of GNAS in infants born to gestational diabetes. [PDF]

BMC Med Genet, 2014
BackgroundOffspring of pregnancy complicated with gestational diabetes (GDM) are at high risk for metabolic diseases. The mechanisms behind the association of intrauterine exposure to GDM and high risk of health problems in later life remain largely ...
Chen D, Zhang A, Fang M, Fang R, Ge J, Jiang Y, Zhang H, Han C, Ye X, Huang H, Liu Y, Dong M.   +11 more
europepmc   +2 more sources

Obesity-Associated Differentially Methylated Regions in Colon Cancer

Journal of Personalized Medicine, 2022
Obesity with adiposity is a common disorder in modern days, influenced by environmental factors such as eating and lifestyle habits and affecting the epigenetics of adipose-based gene regulations and metabolic pathways in colorectal cancer (CRC).
Zhao-Feng Chen, James M Grayson, Pamela Shiao   +2 more
exaly   +2 more sources

IGF2 differentially methylated region hypomethylation in relation to pathological and molecular features of serrated lesions. [PDF]

World J Gastroenterol, 2014
AIM To investigate insulin-like growth factor 2 (IGF2) differentially methylated region (DMR)0 hypomethylation in relation to clinicopathological and molecular features in colorectal serrated lesions.
Naito T, Nosho K, Ito M, Igarashi H, Mitsuhashi K, Yoshii S, Aoki H, Nomura M, Sukawa Y, Yamamoto E, Adachi Y, Takahashi H, Hosokawa M, Fujita M, Takenouchi T, Maruyama R, Suzuki H, Baba Y, Imai K, Yamamoto H, Ogino S, Shinomura Y.   +21 more
europepmc   +2 more sources

No evidence for a parent of origin specific differentially methylated region linked to RASGRF1

Frontiers in Genetics, 2012
Imprinted genes are expressed from one parental allele in a parent-of-origin manner. This mono-allelic behavior is regulated by allele-specific DNA methylation that is confined to differentially methylated regions (DMRs).
Punita ePitamber, Zané eLombard, Michèle eRamsay   +2 more
doaj   +2 more sources

The human HYMAI/PLAGL1 differentially methylated region acts as an imprint control region in mice. [PDF]

Genomics, 2006
Imprinting centers (IC) can be defined as cis-elements that are recognized in the germ line and are epigenetically modified to bring about the full imprinting program in a somatic cell.
T. Arima, K. Yamasaki, R. John, Kiyoko Kato, K. Sakumi, Y. Nakabeppu, N. Wake, T. Kono   +7 more
semanticscholar   +2 more sources

Inter-individual differentially methylated region-targeted EWAS reveals epigenetic signatures of early childhood adversity [PDF]

Epigenomics
Shiori Minabe, Atsushi Shimizu, Shohei Komaki   +2 more
exaly   +2 more sources

Impact of DNA methylation of the human mesoderm-specific transcript (MEST) on male infertility

Heliyon, 2023
Male infertility accounts for nearly 40%–50% of all infertile cases. One of the most prevalent disorders detected in infertile men is errors in the MEST differentially methylated region (DMR), which has been correlated with poor sperm indexes. The aim of
Tayebeh Amjadian, Parichehreh Yaghmaei, Hayati Roodbari Nasim, Kheirollah Yari   +3 more
doaj   +1 more source

Imprinting at the KBTBD6 locus involves species-specific maternal methylation and monoallelic expression in livestock animals

Journal of Animal Science and Biotechnology, 2023
Background The primary differentially methylated regions (DMRs) which are maternally hypermethylated serve as imprinting control regions (ICRs) that drive monoallelic gene expression, and these ICRs have been investigated due to their implications in ...
Jinsoo Ahn, In-Sul Hwang, Mi-Ryung Park, Seongsoo Hwang, Kichoon Lee   +4 more
doaj   +1 more source

Intronic parent-of-origin dependent differential methylation at the Actn1 gene is conserved in rodents but is not associated with imprinted expression. [PDF]

PLoS ONE, 2012
Parent-of-origin differential DNA methylation has been associated with regulation of the preferential expression of paternal or maternal alleles of imprinted genes.
John D Calaway, José Ignacio Domínguez, Megan E Hanson, Ezequiel C Cambranis, Fernando Pardo-Manuel de Villena, Elena de la Casa-Esperon   +5 more
doaj   +1 more source

Genomic Imprinting in the New Omics Era: A Model for Systems-Level Approaches

Frontiers in Genetics, 2022
Genomic imprinting represents a noteworthy inheritance mechanism leading to allele-specific regulations dependent of the parental origin. Imprinted loci are especially involved in essential mammalian functions related to growth, development and behavior.
Jean-Noël Hubert, Julie Demars
doaj   +1 more source