Results 211 to 220 of about 33,170 (247)
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Genomic Imprinting in the Mouse
1989In retrospect, perhaps it is not surprising that in mammals the two parental genomes have different influences on the developing embryo. However, it is only recently that the functional nonequivalence of the maternal and paternal genomes has been established conclusively and so has commanded a considerable amount of interest.
S K, Howlett +4 more
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Genome imprinting and carcinogenesis
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1991The preferential retention of paternal tumor suppressor alleles in sporadic tumors and the failure to demonstrate genetic linkage between disease predisposition and tumor suppressor loci in familial cases indicates that genome imprinting may be involved in the genesis of some pediatric cancers. A genetic model that invokes the activity of modifier loci
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2002
Genomic imprinting, though most extensively studied in mammals, has long been known to perform an important role in seed development in flowering plants. In this chapter, an overview of what is known to date about genomic imprinting in flowering plants and how this knowledge came into being will be given.
R, Vinkenoog +4 more
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Genomic imprinting, though most extensively studied in mammals, has long been known to perform an important role in seed development in flowering plants. In this chapter, an overview of what is known to date about genomic imprinting in flowering plants and how this knowledge came into being will be given.
R, Vinkenoog +4 more
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The Mechanisms of Genomic Imprinting
1999Genomic imprinting can be regarded as one of many variants of epigenetic modes of gene regulation in eukaryotic cells. There is no a priori reason, therefore, to invoke fundamentally novel mechanisms to explain the imprinting phenomenon in mammals. For example, the different factors involved in imprinting, such as the stable propagation of different ...
B, Horsthemke +3 more
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Kinship and Genomic Imprinting
1999Genomic imprinting refers to parent-specific gene expression, that is, to a difference in gene expression depending on which parent contributed the gene. In the usual case, an allele is silent when inherited from one parent while the identical stretch of DNA would be active were it inherited from the other, but sometimes this effect is seen in some ...
R, Trivers, A, Burt
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Genomic imprinting in the brain
Current Opinion in Neurobiology, 1997Human genetic studies have directed attention to genetic imprinting in a number of syndromes involving brain dysfunction, such as Prader-Willi syndrome, Angelman syndrome, Turner's syndrome, bipolar depression and schizophrenia. Molecular genetics is providing insights into the complexity of these imprinting mechanisms, while experimental studies are ...
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1992
This is a good time to write a general article on imprinting. In the last 5 years or so imprinting has progressed from an intriguing embryological observation to a firmly established biological principle with far-reaching consequences for mammalian development, genetics, and human disease. We now know why parthenogenesis in some mammals is not possible.
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This is a good time to write a general article on imprinting. In the last 5 years or so imprinting has progressed from an intriguing embryological observation to a firmly established biological principle with far-reaching consequences for mammalian development, genetics, and human disease. We now know why parthenogenesis in some mammals is not possible.
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1999
Epigenetic programming is most likely the least understood part of the control of gene expression and too broad a subject to consider in a single chapter. The difficulty in studying its role in gene expression is that very few Mendelian mutations cause arrest in epigenetic programming and that chromatin changes occurring many cell divisions before ...
J, Messing, U, Grossniklaus
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Epigenetic programming is most likely the least understood part of the control of gene expression and too broad a subject to consider in a single chapter. The difficulty in studying its role in gene expression is that very few Mendelian mutations cause arrest in epigenetic programming and that chromatin changes occurring many cell divisions before ...
J, Messing, U, Grossniklaus
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Genomic imprinting: parental influence on the genome
Nature Reviews Genetics, 2001Genomic imprinting affects several dozen mammalian genes and results in the expression of those genes from only one of the two parental chromosomes. This is brought about by epigenetic instructions--imprints--that are laid down in the parental germ cells.
W, Reik, J, Walter
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Current Opinion in Pediatrics, 1995
Parental, or genomic, imprinting is a newly described form of genetic regulation, leading to the differential behavior of each parental copy of a gene. The precise mechanism responsible for the imprint, or allele-specific behavior of gene transcription, is still unclear; it is thought that modifications not involving the DNA base sequence (therefore ...
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Parental, or genomic, imprinting is a newly described form of genetic regulation, leading to the differential behavior of each parental copy of a gene. The precise mechanism responsible for the imprint, or allele-specific behavior of gene transcription, is still unclear; it is thought that modifications not involving the DNA base sequence (therefore ...
openaire +2 more sources