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GENOMIC IMPRINTING AND CARCINOGENESIS
Lancet, The, 1988Genomic imprinting might play an important part in the development of several tumours. It is suggested that in Wilms' tumorigenesis, imprinting normally renders inactive a transforming gene on the maternally derived chromosome 11, leaving intact the paternally inherited chromosome 11 and the Wilms' transforming gene that it carries. A similar mechanism
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Genomic Imprinting: Imprinting with and without methylation
Current Biology, 1994Methyltransferase-deficient mice reveal that DNA methylation is required for the somatic-cell maintenance of parental imprinting, which alters the expression of a gene according to the parent from which it was inherited.
W, Reik, N D, Allen
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Genomic imprinting in the mealybugs
Cytogenetic and Genome Research, 2006The coccid insects (Hemiptera; Sternorrhyncha; Aphidiformes; Coccoidea; Pseudococcidae) are well suited to study not only the mechanisms of genomic imprinting but also facultative heterochromatization, a phenomenon well exemplified by inactivation of the X chromosome in female mammals.
S, Khosla, G, Mendiratta, V, Brahmachari
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Annual Review of Genetics, 1997
▪ Abstract  A handful of autosomal genes in the mammalian genome are inherited in a silent state from one of the two parents, and in a fully active form from the other, thereby rendering the organism functionally hemizygous for imprinted genes. To date 19 imprinted genes have been identified; 5 are expressed from the maternal chromosome while the rest
M S, Bartolomei, S M, Tilghman
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▪ Abstract  A handful of autosomal genes in the mammalian genome are inherited in a silent state from one of the two parents, and in a fully active form from the other, thereby rendering the organism functionally hemizygous for imprinted genes. To date 19 imprinted genes have been identified; 5 are expressed from the maternal chromosome while the rest
M S, Bartolomei, S M, Tilghman
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Seminars in Cancer Biology, 1996
In recent years it has become apparent that genomic imprinting may have a role in the development of certain types of cancer. Preferential loss or retention of one parental genotype in chromosomal regions known to be subject to imprinting have been found in specific cancers.
J, Squire, R, Weksberg
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In recent years it has become apparent that genomic imprinting may have a role in the development of certain types of cancer. Preferential loss or retention of one parental genotype in chromosomal regions known to be subject to imprinting have been found in specific cancers.
J, Squire, R, Weksberg
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The evolution of genomic imprinting
Development, 1990ABSTRACT We explore three possible pathways for the evolution of genomic imprinting. (1) Imprinting may be advantageous in itself when imprinted and unimprinted alleles of a locus confer different phenotypes. If a segment of DNA is imprinted in the gametes of one sex but not in those of the other, it might lead to effects correlated with
H S, Chandra, V, Nanjundiah
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In Brief: Genomic imprinting and imprinting diseases
The Journal of Pathology, 2014AbstractGenomic imprinting is an epigenetic process by which the male and the female germline confer different DNA methylation marks and histone modifications onto specific gene regions, so that one allele of an imprinted gene is active and the other one is silent.
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Experimental Cell Research, 1999
Fifteen years have gone by since the initial demonstrations of mammalian genomic imprinting (Barton et al. 1984; McGrath andSolter 1984; Surani et al. 1984), 7 years since the identification of specific imprinted genes in mice (DeChiara et al. 1991; Barlow et al. 1991; Bartolomei et al.
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Fifteen years have gone by since the initial demonstrations of mammalian genomic imprinting (Barton et al. 1984; McGrath andSolter 1984; Surani et al. 1984), 7 years since the identification of specific imprinted genes in mice (DeChiara et al. 1991; Barlow et al. 1991; Bartolomei et al.
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Genomic imprinting in the placenta
Cytogenetic and Genome Research, 2006Genomic imprinting is an epigenetic mechanism that is important for the development and function of the extra-embryonic tissues in the mouse. Remarkably all the autosomal genes which were found to be imprinted in the trophoblast (placenta) only are active on the maternal and repressed on the paternal allele. It was shown for several of these genes that
A, Wagschal, R, Feil
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