Results 131 to 140 of about 1,069,336 (306)

Genomic structural equation modeling uncovers novel risk loci for bone metabolic disorders: cross-tissue genetic mechanisms and bone-brain axis regulation

BMC Musculoskeletal Disorders
Objective The genetic architecture underlying bone metabolic disorders (BMetDs) remains poorly characterized. Utilizing genomic structural equation modeling (Genomic-SEM) and multiple post-GWAS approaches, we estimated causal single nucleotide ...
Yunqiao Zhou, Jian Huang, Leqin Xu, Fan Zhang, Chunxiao Bai, Fangyang Fan, Yuquan Wang, Bixuan Fang, Tian Wang, Xiaohong Mu, Jinyu Li   +10 more
doaj   +1 more source

A genome-wide library of CB4856/N2 introgression lines of Caenorhabditis elegans [PDF]

, 2009
Recombinant inbred lines (RILs) derived from Caenorhabditis elegans wild-type N2 and CB4856 are increasingly being used for mapping genes underlying complex traits.
Jan Kammenga, Snoek, L.B., L. Basten Snoek, Emilie Fradin, Riksen, J.A.G., Joost Riksen, Doroszuk, A., Kammenga, J.E., Agnieszka Doroszuk, Fradin, E.   +9 more
core   +1 more source

Ionic Gating of Liquid‐Crystal‐Like Pteridine Assemblies Enables Tunable Light Scattering

Advanced Materials, EarlyView.
Tunable optical properties emerge through developmentally regulated ionic gating, which transforms disordered, ultraviolet (UV)‐absorbing organelles into concentrically ordered, liquid‐crystal‐like light scatterers. By integrating analyses of pteridine composition, potassium‐dependent assembly, hierarchical ultrastructure, and optical behavior, the ...
Sourabh Bera, Zohar Eyal, Yael Noy, Yuval Barzilay, Siddharth Sahoo, Srikant Moharana, Avi Baram, Tali Lerer‐Goldshtein, Neta Varsano, Bar Bader, Lothar Houben, Uwe Heinig, Iddo Pinkas, Moshe Goldsmith, Tamar Unger, Shira Albeck, Andrea Sorrentino, Maxim Itkin, Sergey Malitsky, Ziv Porat, Ido Hadar, Venkata Jayasurya Yallapragada, Dvir Gur   +22 more
wiley   +1 more source

Different models of genetic variation and their effect on genomic evaluation

Genetics Selection Evolution, 2011
Background The theory of genomic selection is based on the prediction of the effects of quantitative trait loci (QTL) in linkage disequilibrium (LD) with markers. However, there is increasing evidence that genomic selection also relies on "relationships"
Hickey John M, Clark Samuel A, van der Werf Julius HJ   +2 more
doaj   +1 more source

A high-density consensus map of barley linking DArT markers to SSR, RFLP and STS loci and agricultural traits [PDF]

, 2006
Background: Molecular marker technologies are undergoing a transition from largely serial assays measuring DNA fragment sizes to hybridization-based technologies with high multiplexing levels.
Wenzl Peter, Haobing Li, Harsh Raman, Andris Kleinhofs, Huttner, E., Xia Ling, Zhou, M., Wang, J., Hearnden, P., Zhou Meixue, Meixue Zhou, Chalmers, K.J., Paul, E., Ovesná, J., Smith, K., Li Haobing, Muehlbauer Gary J, Caig, V., Huttner Eric, Hearnden Phillippa, Chalmers Ken J, Kleinhofs Andris, Smith Kevin P, Jaroslava Ovesná, Kevin P Smith, Andrzej Kilian, Muehlbauer, G., Rosy Raman, et al., Chalmers, K., Gary J Muehlbauer, Kilian, A., Carling, J., Ken J Chalmers, Paul Edie, David Poulsen, Kilian Andrzej, Raman, R., Junping Wang, Poulsen David, Edie Paul, Phillippa Hearnden, Carling Jason, Peter Wenzl, Ling Xia, Ovesná Jaroslava, Eric Huttner, Wang Junping, Maier Christina, Kleinhofs, A., Mehmet Cakir, Raman, H., Cakir Mehmet, Maier, C., Raman Harsh, Smith, K.P., Muehlbauer, G.J., Caig Vanessa, Jason Carling, Christina Maier, Cakir, M., Raman Rosy, Xia, L., Poulsen, D., Li, H., Vanessa Caig, Wenzl, P., Plant Science   +67 more
core   +2 more sources

Region‐Specific Profiling of the Gut Microbiome and Metabolite Landscape in Response to Dietary Intervention Using Electronics‐Free Ingestible Smart Sampling Capsules

Advanced Materials Technologies, EarlyView.
Region‐specific profiling of the gut microbiome is achieved non‐invasively using electronics‐free ingestible sampling capsules that activate at defined intestinal sites through stimuli‐responsive coatings. Deployed in a porcine dietary intervention model, the capsules resolve spatially distinct, fiber‐driven shifts in microbial composition and short ...
Devendra Sarnaik, Caitlyn Sullivan, Akshay Krishnakumar, Fangxin Chen, Anna Clapp Organski, Wayne W. Campbell, Jay S. Johnson, Tzu‐Wen L. Cross, Rahim Rahimi   +8 more
wiley   +1 more source

Chemical Screening Identifies Danofloxacin as a Self‐Renewal Agonist of Embryonic Stem Cells through Alleviation of HDAC1‐Mediated Deacetylation of Tert and Prdm10

Advanced Science, EarlyView.
This study identified Danofloxacin as a novel supporter of the maintenance of mouse embryonic stem cell (ESC) pluripotency. It functions partially by inhibiting HDAC1, which increases specific histone acetylation marks and activates key genes like Tert and Prdm10.
Yan Zhang, Junxiang Ji, Baoxing Dong, Zhenhua Zhu, Xucheng Lv, Peng Chen, Wenqiang Liu, Min Zhou, Shou‐Dong Ye   +8 more
wiley   +1 more source

Dual Role of Tamoxifen in Enhancing STING and CEACAM1 Expression to Prime a Favorable Tumor Microenvironment for Anti‐TIM3 Immunotherapy

Advanced Science, EarlyView.
Anti‐PD‐1/PD‐L1 blockade has revolutionized cancer immunotherapy, but is ineffective against endocrine‐treated (i.e., Tamoxifen), relapsed ER+ breast cancer (BC) patients. This study provides insight into the sub‐optimal response of ER+BCs to anti‐PD‐1/PD‐L1 blockade – highlighting the induction of STING and the CEACAM1/TIM3 axis after chronic ...
Marvin Angelo E Aberin, Saurabh Singh, Soumya Chatterjee, Guang‐Zhi Sui, Yi‐Fu Wang, Ya‐Ting Lu, Yu‐Ling Lee, Kun‐Yuan Lin, Joy Khag, Ta‐Yu Liu, Shao‐Han Chang, Wai‐Mui Cheung, Hsiao‐Chin Hong, Ren‐Jun Hsu, Chen‐Yang Shen, Chia‐Wei Li, Weng‐Lang Yang, Yao‐Ming Chang, Shih‐Yu Chen, Chandan Guha, Shu‐Ping Wang   +20 more
wiley   +1 more source

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

Sequence and annotation of three genomic loci of sunflower (Helianthus annuus L.).

, 2008
Sequence and annotation of three genomic loci of sunflower (Helianthus annuus L.)
Natali L., Cattonaro F., Morgante M., Cavallini A., BUTI, MATTEO, Giordani T.   +5 more
core