Results 151 to 160 of about 1,069,336 (306)
Inter-strain genetic variation at discrete genomic loci.
, 2014 Data is presented for three distinct genomic loci (A–C). Estimates of copy number and heterozygous allele frequencies were calculated and are presented as in Fig. 1.
Chris D. Curtin (175228) +3 more
core +1 more source
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
, 2018 Three Interacting Genomic Loci Incorporating Two Novel Mutations Underlie the Evolution of Diet-Induced ...
Refael Kohen (5817245) +3 more
core +1 more source
Advanced Science, EarlyView.Deep‐learning‐based signal enhancement is an effective way to recover high‐resolution details from a low‐resolution chromatin contact map. However, due to computational challenges, existing methods commonly divide up the contact map into small patches and create artificial discontinuities at patch boundaries.
Qinyao Li +6 more
wiley +1 more source
, 2016 The number of PoCos identified on each dataset, and the distribution of the genomic loci in each individual PoCo.
Mehmet Koyutürk (254678) +1 more
core +1 more source
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source
Distribution of haplotypes of 6 Nosema genomic loci
, 2016 Count of Roche 454 pyrosequencing haplotypes (rows) of 6 Nosema genomic loci in 31 bumble bee samples (columns). See Table S4 for geographic origins of these bee samples.
Michelle Audrey Duennes (3289422) +9 more
core +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
, 2014 Details of candidate genes, chromosome location, genomic location and strand genotyped at 41 SNP loci under study.
Daniel Medus (522379) +14 more
core +1 more source
Advanced Science, EarlyView.A rare de novo IFT122‐A773E variant is identified in idiopathic pediatric uveitis and shown to exacerbate retinal inflammation and barrier dysfunction. Mechanistically, the variant enhances IFT43 interaction, elevates calcium signaling, and activates the MEK/ERK/FRA1 axis, revealing a previously unrecognized cilia‐associated pathway that may increase ...
Qian Zhou +18 more
wiley +1 more source