Drug Repurposing for Treating NCOR‐Related Intellectual Disability
Advanced Science, EarlyView.An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong +15 more
wiley +1 more source
Discovery of genomic loci for liver health and steatosis reveals overlap with glutathione redox genetics. [PDF]
Redox BiolKoch RL +10 more
europepmc +1 more source
Mapping and annotating genomic loci to prioritize genes and implicate distinct polygenic adaptations for skin color. [PDF]
Nat CommunKim B +14 more
europepmc +1 more source
Exploring Novel Genomic Loci and Candidate Genes Associated with Plant Height in Bulgarian Bread Wheat via Multi-Model GWAS. [PDF]
Plants (Basel)Kartseva T +6 more
europepmc +1 more source
A CRISPR/Cas9-based visual toolkit enabling multiplex integration at specific genomic loci in Aspergillus niger. [PDF]
Synth Syst BiotechnolLi Y +8 more
europepmc +1 more source
Parent-of-Origin-Specific Allelic Associations Among 106 Genomic Loci for Age at Menarche [PDF]
Nature, 2014 Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and all-cause mortality.
Ilja M Nolte +2 more
exaly +3 more sources
Genomic Imprinting of Two Antagonistic Loci [PDF]
Proceedings of the Royal Society of London Series B, Biological Sciences, 2001 We present a model that considers the coevolution of genomic imprinting at a growth factor locus and an antagonistic growth suppressor locus. With respect to the two loci considered independently, our model makes the familiar predictions that an imprinted growth factor locus will only be expressed from the paternally derived allele and an imprinted ...
Jon Wilkins, David Haig
exaly +3 more sources
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Prophage loci predictor for bacterial genomes
Journal of Bioinformatics and Computational Biology, 2021This paper proposes a new algorithm for prophage loci prediction in bacteria. Prophages are defined in Bioinformatics as viral nucleotide sequences that are found intermixed with host nucleotide sequences in bacteria. The proposed algorithm uses machine learning patterns and processing methodologies in order to provide a highly efficient system for ...
Manu Rajan Nair, T. Amudha
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Genome Scan for Susceptibility Loci for Schizophrenia
Neuropsychobiology, 2000<i>Objective:</i> Schizophrenia is a relatively common, often chronic and debilitating mental illness. Evidence from various studies has clearly demonstrated that genetic factors contribute substantially to the etiology. The goal of this study was to identify chromosomal regions likely to contain schizophrenia susceptibility genes. <i>
U, Bailer +12 more
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SCANNING THE GENOME FOR ESSENTIAL HYPERTENSION LOCI
Clinical and Experimental Pharmacology and Physiology, 1998SUMMARY1. Essential hypertension occurs in people with an underlying genetic predisposition who subject themselves to adverse environmental influences. The number of genes involved is unknown, as is the extent to which each contributes to final blood pressure and the severity of the disease.2. In the past, studies of potential candidate genes have been
Morris, B. J., Griffiths, Lyn R.
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