Results 271 to 280 of about 1,069,336 (306)

Structural characterization of GnRH loci in the medaka genome

Gene, 2002
To help clarify the origin of a third gonadotropin-releasing hormone (GnRH) paralog found only in the teleost lineage, we have characterized GnRH loci in a teleost species, the medaka Oryzias latipes, and compared corresponding regions of the medaka and human genomes.
Kataaki, Okubo, Hiroshi, Mitani, Kiyoshi, Naruse, Mariko, Kondo, Akihiro, Shima, Minoru, Tanaka, Shuichi, Asakawa, Nobuyoshi, Shimizu, Yasutoshi, Yoshiura, Katsumi, Aida   +9 more
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A genome‐wide scan for modifier loci in schizophrenia

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2007
AbstractThe purpose of this study was to detect genetic loci that influence clinical features of, but not necessarily susceptibility to, psychotic illness. In the Irish Study of High‐Density Schizophrenia Families (n = 270 families, n = 1,408 individuals), subjects with non‐affective psychosis were rated using the Operational Criteria Checklist for ...
Fanous, Ayman H., Neale, Michael C., Webb, B. Todd, Straub, Richard E., Amdur, Richard L., O'Neill, F. Anthony, Walsh, Dermot, Riley, Brien P., Kendler, Kenneth S.   +8 more
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Identification of highly conserved loci by genome painting

Chromosome Research, 1995
Fluorescence in situ hybridization was used to identify patterns of DNA similarity among the genomes of several rodent taxa. Total genomic or Cot-1 DNAs were used as hybridization probes against metaphase preparations across different taxonomic levels, including three species of Microtus (suborder Sciurognathi), three species of Microtus (suborder ...
T W, Houseal, J A, Cook, W S, Modi, D W, Hale   +3 more
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Searching for Additional Disease Loci in a Genomic Region

2008
Our aim is to review methods to optimize detection of all disease genes in a genetic region. As a starting point, we assume there is sufficient evidence from linkage and/or association studies, based on significance levels or replication studies, for the involvement in disease risk of the genetic region under study.
Glenys, Thomson, Lisa F, Barcellos, Ana M, Valdes   +2 more
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Genome Screening for Susceptibility Loci in Systemic Lupus Erythematosus

American Journal of PharmacoGenomics, 2002
Systemic lupus erythematosus (SLE) is a complex, multigenic autoimmune disease with a wide spectrum of clinical manifestations. Much of the pathology is attributed to deposition to various tissues of immune complexes continuously formed with autoantibodies; thus, the pathogenesis is related to dysregulation of self-reactive B cells.
Toshikazu, Shirai, Hiroyuki, Nishimura, Yi, Jiang, Sachiko, Hirose   +3 more
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Genome-wide studies of psoriasis susceptibility loci: a review

Journal of Dermatological Science, 2004
Psoriasis is a chronic inflammatory dermatosis affecting approximately 0.3-5% world-wide. Since 1997, nine genome-wide scans have been published in the search for predisposing genes to psoriasis and psoriatic arthritis. These genome-wide scans have provided results that both confirm earlier work, but which also suggest novel regions of interest on the ...
Gurdeep S, Sagoo, Michael J, Cork, Ramila, Patel, Rachid, Tazi-Ahnini   +3 more
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Genomic loci with pleiotropic effects on coronary artery calcification

Atherosclerosis, 2006
We measured 381 genomewide markers and performed genetic linkage analyses in search of loci influencing coronary artery calcification (CAC), a measure of atherosclerosis determined by electron beam computed tomography, in 948 non-Hispanic white siblings (mean age [+/-standard deviation] = 59.6 +/- 9.9 years; 73.7% hypertensive).
Stephen T, Turner, Patricia A, Peyser, Sharon L R, Kardia, Lawrence F, Bielak, Patrick F, Sheedy, Eric, Boerwinkle, Mariza, de Andrade   +6 more
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Visualization of Genomic Loci in Living Cells with BiFC‐TALE

Current Protocols in Cell Biology, 2018
AbstractTracking the dynamics of genomic loci is essential for understanding a variety of cellular processes. However, earlier methods have all suffered from a low signal‐to‐background ratio (SBR), mainly caused by the background fluorescence from diffuse full‐length fluorescent proteins in the nucleus.
Huan, Hu, Xiaojing, Yang, Chao, Tang
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Identification and prioritization of genomic loci with disease-specific methylation

2014
Epigenetic systems are an indispensable mechanism in development, they respond to environmental stimuli and are dysregulated in cancer and other diseases. DNA methylation is the best characterized and extensively studied epigenetic mark to date. In the past years, a number of assays have been designed to measure DNA methylation levels genome-wide. This
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Genome Scanning for Quantitative Trait Loci

2012
In the previous chapters, we learned the basic concept of quantitative genetics, the quantitative genetics model, the method for major gene detection (genotypes of the major gene are observed), and the algorithm for segregation analysis (genotypes of the major gene are not observed).
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