Results 61 to 70 of about 536,771 (324)

ModHMM: A Modular Supra-Bayesian Genome Segmentation Method [PDF]

, 2020
Genome segmentation methods are powerful tools to obtain cell type or tissue-specific genome-wide annotations and are frequently used to discover regulatory elements.
Benner, P., Vingron, M.
core   +2 more sources

Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target

FEBS Letters, EarlyView.
This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz, Milagros Siebeck Caturelli, Lina S. Lehmann, Florian Kurth, Alexander G. Maier, Kai Matuschewski   +5 more
wiley   +1 more source

Effect of breed composition in genomic prediction using crossbred pig reference population

Journal of Animal Science and Technology
In contrast to conventional genomic prediction, which typically targets a single breed and circumvents the necessity for population structure adjustments, multi-breed genomic prediction necessitates accounting for population structure to mitigate ...
Euiseo Hong, Yoonji Chung, Phuong Thanh N. Dinh, Yoonsik Kim, Suyeon Maeng, Young jae Choi, Jaeho Lee, Woonyoung Jeong, Hyunji Choi, Seung Hwan Lee   +9 more
doaj   +1 more source

Multivariate GBLUP Improves Accuracy of Genomic Selection for Yield and Fruit Weight in Biparental Populations of Vaccinium macrocarpon Ait

Frontiers in Plant Science, 2018
The development of high-throughput genotyping has made genome-wide association (GWAS) and genomic selection (GS) applications possible for both model and non-model species.
Giovanny Covarrubias-Pazaran, Brandon Schlautman, Luis Diaz-Garcia, Luis Diaz-Garcia, Edward Grygleski, James Polashock, Jennifer Johnson-Cicalese, Nicholi Vorsa, Massimo Iorizzo, Juan Zalapa   +9 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Genomic predictions under different genetic architectures are impacted by mating designs

Veterinary and Animal Science
Mating in animal communities must be managed in a way that assures the performance increase in the progenies without increasing the rate of inbreeding. It has currently become possible to identify millions of single nucleotide polymorphisms (SNPs), and ...
Sahar Ansari, Navid Ghavi Hossein-Zadeh, Abdol Ahad Shadparvar   +2 more
doaj   +1 more source

Use of partial least squares regression to impute SNP genotypes in Italian Cattle breeds [PDF]

, 2013
Background The objective of the present study was to test the ability of the partial least squares regression technique to impute genotypes from low density single nucleotide polymorphisms (SNP) panels i.e. 3K or 7K to a high density panel with 50K SNP.
AJ Chamberlain, APW de Roos, BJ Hayes, BJ Hayes, BJ Hayes, BL Browning, C Dimauro, C Hagger, Corrado Dimauro, D Boichard, D Segelke, DP Berry, G Li, G Moser, Gabriele Marras, GCB Schopen, Giustino Gaspa, H Abdi, HA Mulder, HD Daetwyler, I Medugorac, J Chen, JE Pryce, JM Hickey, K Kizilkaya, KA Weigel, KA Weigel, Massimo Cellesi, Nicolò PP Macciotta, P Ajmone-Marsan, P Scheet, Paolo Ajmone-Marsan, PM VanRaden, R Dassonneville, R Dassonneville, Roberto Steri, T Druet, T Druet, TH Meuwissen, Z Zhang   +39 more
core   +3 more sources

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Multi-environment analysis enhances genomic prediction accuracy of agronomic traits in sesame

Frontiers in Genetics, 2023
Introduction: Sesame is an ancient oilseed crop containing many valuable nutritional components. The demand for sesame seeds and their products has recently increased worldwide, making it necessary to enhance the development of high-yielding cultivars ...
Idan Sabag, Idan Sabag, Ye Bi, Zvi Peleg, Gota Morota   +4 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source