Results 121 to 130 of about 4,045,535 (372)

SWEEPFINDER2: Increased sensitivity, robustness, and flexibility

, 2015
SweepFinder is a popular program that implements a powerful likelihood-based method for detecting recent positive selection, or selective sweeps. Here, we present SweepFinder2, an extension of SweepFinder with increased sensitivity and robustness to the ...
DeGiorgio, Michael, Hellmann, Ines, Huber, Christian D., Hubisz, Melissa J., Nielsen, Rasmus   +4 more
core   +1 more source

Efficiency of genomic selection using Bayesian multi-marker models for traits selected to reflect a wide range of heritabilities and frequencies of detected quantitative traits loci in mice [PDF]

, 2012
BACKGROUND: Genomic selection uses dense single nucleotide polymorphisms (SNP) markers to predict breeding values, as compared to conventional evaluations which estimate polygenic effects based on phenotypic records and pedigree information.
Ashworth, Cheryl J., Janss, Luc L. G., Kapell, Dagmar N. R. G., Roehe, Rainer, Sorensen, Daniel, Su, Guosheng   +5 more
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Advances in oil palm genomic selection [PDF]

, 2019
More efficient methods are required to breed oil palm (Elaeis guineensis Jacq.) for yield maximization, in order to meet the increased demand for palm oil while limiting environmental impacts.
Afandi, Dadang, Cochard, Benoît, Cros, David, Jacob, Florence, Nyouma, Achille, Syahputra, Indra, Tchounke, Billy   +6 more
core  

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Response to genomic selection: The Bulmer effect and the potential of genomic selection when the number of phenotypic records is limiting

Genetics Selection Evolution, 2012
Background Over the last ten years, genomic selection has developed enormously. Simulations and results on real data suggest that breeding values can be predicted with high accuracy using genetic markers alone.
Van Grevenhof Elizabeth M, Van Arendonk Johan AM, Bijma Piter   +2 more
doaj   +1 more source

Genomic Selection for Optimum Index with Dry Biomass Yield, Dry Mass Fraction of Fresh Material, and Plant Height in Biomass Sorghum [PDF]

, 2020
Ephrem Habyarimana, Marco Lopez‐Cruz, Faheem Shehzad Baloch   +2 more
openalex   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Optimising desired gain indices to maximise selection response

Frontiers in Plant Science
IntroductionIn plant breeding, we often aim to improve multiple traits at once. However, without knowing the economic value of each trait, it is hard to decide which traits to focus on.
Reem Joukhadar, Yongjun Li, Rebecca Thistlethwaite, Kerrie L. Forrest, Josquin F. Tibbits, Richard Trethowan, Richard Trethowan, Matthew J. Hayden, Matthew J. Hayden   +8 more
doaj   +1 more source

Genome-wide profiling of human cap-independent translation-enhancing elements. [PDF]

, 2013
We report an in vitro selection strategy to identify RNA sequences that mediate cap-independent initiation of translation. This method entails mRNA display of trillions of genomic fragments, selection for initiation of translation and high-throughput ...
Briones, Natalia, Chaput, John C, Jacobs, Bertram L, Kukurba, Kim, Kumar, Sudhir, Larsen, Andrew C, Liu, Li, Snyder, Michael, Stephens, Bret, Waern, Karl, Wellensiek, Brian P   +10 more
core