Results 51 to 60 of about 552,224 (245)

Estimating Translational Selection in Eukaryotic Genomes [PDF]

Molecular Biology and Evolution, 2008
Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the selection coefficients involved are very small.
dos Reis, M, Wernisch, L
openaire   +4 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Training Population Optimization for Genomic Selection [PDF]

The Plant Genome, 2019
Core Ideas Training populations can be optimized for specific testing populations. Optimized training populations are smaller, more related, and more predictive.
BERRO, I., LADO, B., NALIN, R.S., QUINCKE, M., GUTIÉRREZ, L.   +4 more
openaire   +4 more sources

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

ICGRM: integrative construction of genomic relationship matrix combining multiple genomic regions for big dataset

BMC Bioinformatics, 2019
Background Genomic prediction is an advanced method for estimating genetic values, which has been widely accepted for genetic evaluation in animal and disease-risk prediction in human. It estimates genetic values with genome-wide distributed SNPs instead
Dan Jiang, Cong Xin, Jinhua Ye, Yingbo Yuan, Ming Fang   +4 more
doaj   +1 more source

Improving the efficiency of genomic selection [PDF]

Statistical Applications in Genetics and Molecular Biology, 2013
17 pages, 5 ...
Scutari, M, Mackay, I, Balding, D
openaire   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Genomic prediction of survival traits for scuticociliatosis resistance in a vaccinated olive flounder cohort: Comprehensive evaluation and optimization of statistical and machine learning models

Aquaculture Reports
Genomic prediction utilizes genome-wide markers to facilitate genomic selection in aquaculture, enabling more precise and accelerated genetic gains compared to traditional pedigree-based methods.
Yasara Kavindi Kodagoda, Gaeun Kim, D.S. Liyanage, W.K.M. Omeka, Cheonguk Park, Jeongeun Kim, H.A.C.R. Hanchapola, M.A.H. Dilshan, D.C.G. Rodrigo, G.A.N.P. Ganepola, David B. Jones, Cecile Massault, Dean R. Jerry, Jihun Lee, Jehee Lee   +14 more
doaj   +1 more source

Turning science on robust cattle into improved genetic selection decisions

Animal, 2012
More robust cattle have the potential to increase farm profitability, improve animal welfare, reduce the contribution of ruminant livestock to greenhouse gas emissions and decrease the risk of food shortages in the face of increased variability in the ...
P.R. Amer
doaj   +1 more source

Identification of superior parental lines for biparental crossing via genomic prediction.

PLoS ONE, 2020
A parental selection approach based on genomic prediction has been developed to help plant breeders identify a set of superior parental lines from a candidate population before conducting field trials.
Ping-Yuan Chung, Chen-Tuo Liao
doaj   +1 more source