Results 51 to 60 of about 546,866 (293)

Anti-Inflammatory Effect of Deep-Sea Mineral Water on LPS-Induced Inflammation in Raw 264.7 Murine Macrophage Cells and Zebrafish Larvae

open access: yesImmuno
Deep-sea mineral water (DSW) consists of different compositions and properties. The composition can be varied in different seas all around the world.
Hitihami M. S. M. Wijerathna   +5 more
doaj   +1 more source

Estimating Translational Selection in Eukaryotic Genomes [PDF]

open access: yesMolecular Biology and Evolution, 2008
Natural selection on codon usage is a pervasive force that acts on a large variety of prokaryotic and eukaryotic genomes. Despite this, obtaining reliable estimates of selection on codon usage has proved complicated, perhaps due to the fact that the selection coefficients involved are very small.
dos Reis, M, Wernisch, L
openaire   +4 more sources

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

open access: yesFEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang   +8 more
wiley   +1 more source

ICGRM: integrative construction of genomic relationship matrix combining multiple genomic regions for big dataset

open access: yesBMC Bioinformatics, 2019
Background Genomic prediction is an advanced method for estimating genetic values, which has been widely accepted for genetic evaluation in animal and disease-risk prediction in human. It estimates genetic values with genome-wide distributed SNPs instead
Dan Jiang   +4 more
doaj   +1 more source

Identification of superior parental lines for biparental crossing via genomic prediction.

open access: yesPLoS ONE, 2020
A parental selection approach based on genomic prediction has been developed to help plant breeders identify a set of superior parental lines from a candidate population before conducting field trials.
Ping-Yuan Chung, Chen-Tuo Liao
doaj   +1 more source

Training Population Optimization for Genomic Selection [PDF]

open access: yesThe Plant Genome, 2019
Core Ideas Training populations can be optimized for specific testing populations. Optimized training populations are smaller, more related, and more predictive.
BERRO, I.   +4 more
openaire   +4 more sources

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

open access: yesFEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Turning science on robust cattle into improved genetic selection decisions

open access: yesAnimal, 2012
More robust cattle have the potential to increase farm profitability, improve animal welfare, reduce the contribution of ruminant livestock to greenhouse gas emissions and decrease the risk of food shortages in the face of increased variability in the ...
P.R. Amer
doaj   +1 more source

Improving the efficiency of genomic selection [PDF]

open access: yesStatistical Applications in Genetics and Molecular Biology, 2013
17 pages, 5 ...
Scutari, M, Mackay, I, Balding, D
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

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