Results 121 to 130 of about 245,781 (306)

Tracking the prevalence and emergence of SARS-CoV-2 variants of concern using a regional genomic surveillance program

Microbiology Spectrum
SARS-CoV-2 molecular testing coupled with whole-genome sequencing is instrumental for real-time genomic surveillance. Genomic surveillance is critical for monitoring the spread of variants of concern (VOCs) as well as discovery of novel variants.
Ana Jung, Lindsay Droit, Binita Febles, Catarina Fronick, Lisa Cook, Scott A. Handley, Bijal A. Parikh, David Wang   +7 more
doaj   +1 more source

Genomic characterization of antibiotic resistant Escherichia coli isolated from domestic chickens in Pakistan [PDF]

, 2019
Poultry husbandry is important for the economic health of Pakistan, but the Pakistani poultry industry is negatively impacted by infections ...
Abbas, Muhammad Athar, Ali Malik, Akbar, Ali, Naeem, Burnham, Carey-Ann D, D\u27Souza, Alaric W, Dantas, Gautam, Ferreiro, Aura, Potter, Robert F, Rafique, Muhammad, Rahim, Abdul, Siddique, Naila, Wallace, Meghan A   +11 more
core   +1 more source

Influenza Virus Genomic Surveillance, Arizona, USA, 2023-2024

Viruses
AbstractWe conducted genomic sequencing of 110 influenza A and 30 influenza B viruses from specimens collected between October 2023 and February 2024 in Arizona, USA. We identified mutations in the hemagglutinin (HA) antigenic sites. Real-time genomic surveillance is important to ensure influenza vaccine effectiveness.
Rabia Maqsood, Matthew F. Smith, LaRinda A. Holland, Regan A. Sullins, Steven C. Holland, Michelle Tan, Gabrielle M. Hernandez Barrera, Alexis W. Thomas, Mario Islas, Joanna L. Kramer, Lora Nordstrom, Mary Mulrow, Michael White, Vel Murugan, Efrem S. Lim   +14 more
openaire   +3 more sources

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk

Advanced Science, EarlyView.
Integration of a pancreatic eQTL map with a GWAS meta‐analysis identifies 82 putative functional variants and 15 genes. The association between rs11102484 and pancreatic cancer risk is observed in a total of 5699 cases and 8467 controls. The G allele of rs11102484 weakens ZNF263 binding and the silencer‐promoter interaction, thereby increasing ST7L ...
Xiaoyang Wang, Hui Geng, Zhengyan Yao, Yuan Jiang, Can Chen, Zequn Lu, Shuangshuang Tian, Ming Zhang, Ruiyan Liu, Chenxi Feng, Bin Li, Xiaoping Miao, Jianbo Tian, Shaokai Zhang, Ying Zhu   +14 more
wiley   +1 more source

Genomic surveillance of SARS-CoV-2 in Taiwan: A perspective on evolutionary data interpretation and sequencing issues

Biomedical Journal
This review presents a comprehensive perspective on the genomic surveillance of SARS-CoV-2 in Taiwan, with a focus on next-generation sequencing and phylogenetic interpretation.
Yu-Nong Gong, Nai-Yu Kuo, Ting-Syuan Yeh, Shin-Ru Shih, Guang-Wu Chen   +4 more
doaj   +1 more source

Diversity Patterns of Domestic Herbivore Viruses in China Reveal Transmission Dynamics with Disease Management Implications

Advanced Science, EarlyView.
This study performs pan‐viromic profiling of 14,529 samples from 5,710 domestic herbivores across five Chinese provinces, establishing the DhCN‐Virome (1,085,360 viral metagenomes). It reveals species/sample‐specific viromic signatures and cross‐species transmission dynamics, aiding unified disease control.
Yue Sun, Yong Li, Bagen Temur, Yuanqing Lin, Yuhang Liu, Le Yi, Zheng Sun, Gang Zhang, Jun Li, Yu Guo, Linchuan Li, Jinshan Cai, Wenliang Tian, Gen Meng, Lingling Jiang, Min Fang, Fuying Ding, Xuezhang Zhou, Changchun Tu, Biao He   +19 more
wiley   +1 more source

Enhancing clinical microbiology for genomic surveillance of antimicrobial resistance implementation in Africa

Antimicrobial Resistance and Infection Control
Surveillance is essential in the fight against antimicrobial resistance (AMR), to monitor the extent of resistance, inform prevention, control measures, and evaluate intervention progress.
Henry M Kajumbula, Daniel Gyamfi Amoako, Sofonias K Tessema, Mabel Kamweli Aworh, Francis Chikuse, Iruka N Okeke, Uduak Okomo, Sabelle Jallow, Beverly Egyir, Aquillah M Kanzi, Abdul Karim Sesay, Yewande Habibat Alimi, Kwabena O Duedu, Olga Perovic   +13 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

LANDSCAPE OF HIV-1 VIRAL DIVERSITY IN BRAZIL: A DECADE OF GENOTYPING

Brazilian Journal of Infectious Diseases
Introduction/Objectives: The HIV-1 epidemic continues to be a public health challenge in Brazil. Viral mutations allow the virus to escape the immune system and may also lead to resistance to antiretroviral therapy (ART). In this context, the analysis of
André Henrique Barbosa de Carvalho, Danyella Chiodo Silva Pereira, Danielle Alves Gomes Zauli, Renato Santana Aguiar   +3 more
doaj   +1 more source