Results 71 to 80 of about 245,662 (187)

Genome-scale analysis identifies paralog lethality as a vulnerability of chromosome 1p loss in cancer. [PDF]

, 2018
Functional redundancy shared by paralog genes may afford protection against genetic perturbations, but it can also result in genetic vulnerabilities due to mutual interdependency1-5.
Berger, Ashton C, Bhatia, Sangeeta N, Buss, Colin G, Carr, Steven A, Cherniack, Andrew D, Choi, Peter S, Hahn, William C, Krill-Burger, John M, Lage, Kasper, Malolepsza, Edyta, Meyerson, Matthew, Nogueira, Marina F, Pedamallu, Chandra Sekhar, Schenone, Monica, Shih, Juliann, Strathdee, Craig A, Tamayo, Pablo, Tanenbaum, Benjamin, Taylor, Alison M, Tsherniak, Aviad, Vazquez, Francisca, Viswanathan, Srinivas R, Wawer, Mathias J   +22 more
core   +1 more source

Interspecies DNA acquisition by a naturally competent Acinetobacter baumannii strain [PDF]

, 2019
The human pathogen Acinetobacter baumannii possesses high genetic plasticity and frequently acquires antimicrobial resistance genes. Here we investigated the role of natural transformation in these processes. Genomic DNA from different sources, including
Bahiense, Camila dos Santos, Bonomo, Robert A., Dotto, Cristian Marcelo, Fernandez, Jennifer, Iriarte, Andres, Melano, Roberto Gustavo, Montaña, Sabrina Daiana, Perez, Federico, Place, Kori, Ramirez, Maria Soledad, Soler Bistue, Alfonso J. C., Tolmasky, Marcelo E., Traglia, German Matias   +12 more
core   +1 more source

De novo transcriptome assembly reveals sex-specific selection acting on evolving neo-sex chromosomes in Drosophila miranda. [PDF]

, 2014
BackgroundThe Drosophila miranda neo-sex chromosome system is a useful resource for studying recently evolved sex chromosomes. However, the neo-Y genomic assembly is fragmented due to the accumulation of repetitive sequence.
Bachtrog, Doris, Kaiser, Vera B
core   +2 more sources

A Surgical Perspective on Targeted Therapy of Hepatocellular Carcinoma. [PDF]

, 2015
Hepatocellular carcinoma (HCC), the second leading cause of cancer deaths worldwide, is difficult to treat and highly lethal. Since HCC is predominantly diagnosed in patients with cirrhosis, treatment planning must consider both the severity of liver ...
Busuttil, Ronald W, Faltermeier, Claire, Zarrinpar, Ali   +2 more
core   +2 more sources

Whole genome enrichment approach for genomic surveillance of Toxoplasma gondii

Food Microbiology
Pathogenic bacteria, viruses, fungi, and protozoa can cause food and waterborne diseases. Surveillance methods must therefore screen for these pathogens at various stages of water distribution and of food from production to consumption. Detection using nucleic acid amplification methods offer rapid identification, but such methods have limited utility ...
Balaji Sundararaman, Karen Shapiro, Andrea Packham, Lauren E. Camp, Rachel S. Meyer, Beth Shapiro, Richard E. Green   +6 more
openaire   +2 more sources

Disparate co-evolution and prevalence of sulfadoxine and pyrimethamine resistance alleles and haplotypes at dhfr and dhps genes across Africa

Scientific Reports
Sulfadoxine-pyrimethamine (SP), despite emergence of mutations in dhfr and dhps genes associated with lower treatment efficacy, is still recommended for preventive malaria treatment. Therefore, it is important to understand the evolution of P. falciparum
Nina F. D. White, Georgia Whitton, Varanya Wasakul, Lucas Amenga-Etego, Antoine Dara, Voahangy Andrianaranjaka, Milijaona Randrianarivelojosia, Olivo Miotto, Umberto D’Alessandro, Abdoulaye Djimdé, Cristina V. Ariani, Richard D. Pearson, Alfred Amambua-Ngwa   +12 more
doaj   +1 more source

The paradox of cancer genes in non-malignant conditions: implications for precision medicine. [PDF]

, 2020
Next-generation sequencing has enabled patient selection for targeted drugs, some of which have shown remarkable efficacy in cancers that have the cognate molecular signatures.
Adashek, Jacob J, Kato, Shumei, Kurzrock, Razelle, Lippman, Scott M   +3 more
core  

Profiling the resistome and virulome of Bacillus strains used for probiotic-based sanitation: a multicenter WGS analysis

BMC Genomics
Background Healthcare-associated infections (HAIs) caused by microbes that acquire antimicrobial resistance (AMR) represent an increasing threat to human health worldwide. The high use of chemical disinfectants aimed at reducing the presence of pathogens
Francesca Bini, Irene Soffritti, Maria D’Accolti, Eleonora Mazziga, Julio Diaz Caballero, Sophia David, Silvia Argimon, David M. Aanensen, Antonella Volta, Matteo Bisi, Sante Mazzacane, Elisabetta Caselli   +11 more
doaj   +1 more source

The Exosome Subunit Rrp44 Plays a Direct Role in RNA Substrate Recognition [PDF]

, 2007
The exosome plays key roles in RNA maturation and surveillance, but it is unclear how target RNAs are identified. We report the functional characterization of the yeast exosome component Rrp44, a member of the RNase II family.
Anderson, James T., Schneider, Claudia, Tollervey, David   +2 more
core   +2 more sources

AMR Surveillance in Africa: Are We There Yet?

International Journal of Infectious Diseases
Delineating the burden of antimicrobial resistance (AMR), detecting outbreaks due to multidrug resistant-bacteria and monitoring AMR trends for the early warning of emerging/escalating AMR in humans, animals, plants and the environment requires high ...
Prof Sabiha Essack, Sabiha Y. Essack
doaj   +1 more source