Results 221 to 230 of about 179,984 (263)

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, Volume 2, Issue 2, June 2026.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

A RNase H2-Linked TaqMan-MGB Quantitative Real-Time PCR Assay for Differential Detection of <i>Mycoplasma hyopneumoniae</i> Live-Attenuated Vaccine Strains. [PDF]

Transbound Emerg Dis
Peng K, Wei Y, Wu Y, Yuan T, Li J, Jiang P, Xie Q, Feng Z.   +7 more
europepmc   +1 more source

Holistic bone developing microenvironment engineered apoptotic extracellular vesicles recapitulate multidimensional developmental signatures in adult and senile bone repair

Interdisciplinary Medicine, EarlyView.
The developing bone was identified as an M2a‐like macrophage driven immune microenvironment with multidimensional developmental signatures. hME‐ApoEVs were successfully fabricated via stimulating the M2a‐like developing microenvironment in vitro and confirmed its recapitulation of developmental features.
Xiaoran Yu, Jieyun Xu, Yuan Zhao, Xinyu Guo, Hongcheng Chen, Junlong Xue, Yong Ao, Linjun Zhang, Xiaomeng Gao, Xueli Mao, Songtao Shi, Zetao Chen   +11 more
wiley   +1 more source

DNA-PKcs inhibitor AZD7648 reveals sgRNA cross-contaminants and enhanced sensitivity of genome engineering off-target activity in HSPCs. [PDF]

Nucleic Acids Res
White N, Hu YT, Chalk JA, Kurgan G, Naseem A, Schmaljohn E, Sturgeon M, Cavazza A, Thrasher AJ, Turchiano G.   +9 more
europepmc   +1 more source

Ordered assembly of Cas12a for better performance of CRISPR/Cas system with application to the diagnosis of dental caries

Interdisciplinary Medicine, EarlyView.
Here, we present a tetrahedral DNA framework (TDF)‐mediated Cas12a ordered assembly strategy. TDFs arrange CRISPR/Cas12a into ordered structures controllably, enhancing catalytic efficiency through localized Cas12a hotspots while maintaining spatial intervals to facilitate substrate diffusion.
Yining Zhao, Panpan Qiao, Yujing Zeng, Murtaza Sayed, Qin Mi, Juan Zhang, Genxi Li   +6 more
wiley   +1 more source

Non-B DNA structures and their contributions to genetic diversity, aging, and disease. [PDF]

Nucleic Acids Res
Bochalis E, Dereki I, Wang G, Sgourou A, Vasquez KM, Georgakopoulos-Soares I.   +5 more
europepmc   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Protocol for generating endogenous degron tags in essential transcription factors in human iPSCs via CRISPR-Cas9. [PDF]

STAR Protoc
Li Z, Roberts A, Nimse U, Vu L, Fei J.
europepmc   +1 more source

Reorganizing the RNA polymerase II complex for replication of an infectious noncoding RNA in vivo. [PDF]

PLoS Pathog
Hao J, Qin Z, Ma J, Qu J, Wang Y, Folimonova SY, Liu B, Li W, Wang Y.   +8 more
europepmc   +1 more source

Biocatalytic ulvan degradation by Pseudoalteromonas marina: exploring a marine polysaccharide bioconversion system. [PDF]

Microb Cell Fact
Gajanayaka ND, Jo E, Bandara MS, Lee YJ, Lee J, Marasinghe SD, Sathyadith J, Eom TY, Park GH, Oh C, Lee Y.   +10 more
europepmc   +1 more source