Results 41 to 50 of about 1,456,521 (329)

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Highlights on the Application of Genomics and Bioinformatics in the Fight Against Infectious Diseases: Challenges and Opportunities in Africa

Frontiers in Genetics, 2018
Genomics and bioinformatics are increasingly contributing to our understanding of infectious diseases caused by bacterial pathogens such as Mycobacterium tuberculosis and parasites such as Plasmodium falciparum. This ranges from investigations of disease
Saikou Y. Bah, Saikou Y. Bah, Collins Misita Morang’a, Jonas A. Kengne-Ouafo, Lucas Amenga–Etego, Gordon A. Awandare   +5 more
doaj   +1 more source

Can an infectious disease genomics project predict and prevent the next pandemic? [PDF]

PLoS Biology, 2009
The world of genomics is transforming medicine, and is likely to influence the future development of new drugs, diagnostics, and vaccines. To date, the greater focus of genomics and medicine has been on conditions affecting resourcewealthy settings ...
Rajesh Gupta, Mark H Michalski, Frank R Rijsberman   +2 more
doaj   +1 more source

Autism genetics: searching for specificity and convergence. [PDF]

, 2012
Advances in genetics and genomics have improved our understanding of autism spectrum disorders. As many genes have been implicated, we look to points of convergence among these genes across biological systems to better understand and treat these ...
Berg, Jamee M, Geschwind, Daniel H
core   +1 more source

The neglected genome [PDF]

EMBO reports, 2012
The mitochondrial genome, though tiny, is vital to life. Modern high‐throughput investigations should pay closer attention to this minute genetic treasure trove.
Pesole G, Allen JF, Lane N, Martin W, Rand DM, Schatz G, Saccone C   +6 more
openaire   +6 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

A genomics learning framework for undergraduates.

PLoS ONE
Genomics is an increasingly important part of biology research. However, educating undergraduates in genomics is not yet a standard part of life sciences curricula.
Laura K Reed, Adam J Kleinschmit, Vincent Buonaccorsi, Arthur G Hunt, Douglas Chalker, Jason Williams, Christopher J Jones, Juan-Carlos Martinez-Cruzado, Anne Rosenwald   +8 more
doaj   +1 more source

Medicago truncatula functional genomics: an invaluable resource for studies on agriculture sustainability [PDF]

, 2012
Legume functional genomics has moved many steps forward in the last two decades thanks to the improvement of genomics technologies and to the efforts of the research community.
Calderini, Ornella, Panara, Francesco, Porceddu, Andrea   +2 more
core  

Genomics of Fagaceae [PDF]

Tree Genetics & Genomes, 2012
An overview of recent achievements and development of genomic resources in the Fagaceae is provided, with major emphasis on the genera Castanea and Quercus. The Fagaceae is a large plant family comprising more than 900 species belonging to 8-10 genera.
Christophe Plomion, Christophe Plomion, Paul S. Manos, Margaret Staton, Giovanni G. Vendramin, P. H. Sisco, Antoine Kremer, Antoine Kremer, John E. Carlson, Saneyoshi Ueno, Albert G. Abbott   +10 more
openaire   +5 more sources

B cell mechanobiology in health and disease: emerging techniques and insights into therapeutic responses

FEBS Letters, EarlyView.
B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro, Marco Cellani, Cristina Scielzo   +2 more
wiley   +1 more source