Results 51 to 60 of about 860,476 (247)

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

A qualitative study of genomics in cancer control for Aboriginal and Torres Strait Islander Australians

Australian and New Zealand Journal of Public Health
Objective: To describe the perspectives of Aboriginal and Torres Strait Islander peoples and health care workers on genomics in cancer care to inform the National Framework for Genomics in Cancer Control (the Framework). Methods: A total of 37 Aboriginal
Justine Clark, Jacinta Elston, Kelly Trudgen, Lucy Coulter, Carolyn Der Vartanian, Ashleigh R. Sharman, Claire Howlett, Vivienne Milch, Dorothy Keefe, Alex Brown   +9 more
doaj   +1 more source

Building International Genomics Collaboration for Global Health Security

Frontiers in Public Health, 2015
Genome science and technologies are transforming life sciences globally in many ways, and becoming a highly desirable area for international collaboration to strengthen global health.
Helen H Cui, Tracy eErkkila, Patrick S G Chain, Momchilo eVuyisich   +3 more
doaj   +1 more source

Comparative chloroplast genomics of 34 species in subtribe Swertiinae (Gentianaceae) with implications for its phylogeny [PDF]

, 2023
Lucun Yang, Shengxue Deng, Yongqing Zhu, Qilin Da   +3 more
openalex   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Application and Progress of Genomics in Deciphering the Genetic Regulation Mechanisms of Plant Secondary Metabolites

Plants
This review aims to systematically dissect the genetic regulatory mechanisms of plant secondary metabolites in the era of genomics, while comprehensively summarizing the progress and potential impact of genomics in plant secondary metabolism research. By
Chong Liu, Hang Xu, Zheng Li, Yukun Wang, Siwei Qiao, Hao Zhang   +5 more
doaj   +1 more source

Unexpected genomic features of high current density-producing Geobacter sulfurreducens strain YM18 [PDF]

, 2021
Takashi Fujikawa, Yoshitoshi Ogura, Koki Ishigami, Yoshihiro Kawano, Miyuki Nagamine, Tetsuya Hayashi, Kengo Inoue   +6 more
openalex   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Review of State Comprehensive Cancer Control Plans for Genomics Content

Preventing Chronic Disease, 2005
Introduction The goals of this study were to determine U.S. states with Comprehensive Cancer Control plans that include genomics in some capacity and to review successes with and barriers to implementation of genomics-related cancer control initiatives.
Robert C. Millikan, DVM, PhD, Tejinder Rakhra-Burris, MA, Erin Shaughnessy Zuiker, MPH, Debra E. Irwin, PhD, MSPH   +3 more
doaj  

Comparative genomic analysis revealed genetic divergence between Bifidobacterium catenulatum subspecies present in infant versus adult guts [PDF]

, 2022
Jiaqi Liu, Weicheng Li, Caiqing Yao, Jie Yu, Heping Zhang   +4 more
openalex   +1 more source