Results 11 to 20 of about 73,191 (264)

Genotoxicity of Aspartame [PDF]

Drug and Chemical Toxicology, 2004
In the present study, the genotoxic effects of the low-calorie sweetener aspartame (ASP), which is a dipeptide derivative, was investigated using chromosome aberration (CA) test, sister chromatid exchange (SCE) test, micronucleus test in human lymphocytes and also Ames/Salmonella/ microsome test.
Rencüzogullari E., Tüylü B.A., Topaktaş M., Ila H.B., Kayraldiz A., Arslan M., Diler S.B.   +6 more
openaire   +2 more sources

Genotoxicity of Silver Nanoparticles [PDF]

Nanomaterials, 2020
Silver nanoparticles (AgNPs) are widely used in diverse sectors such as medicine, food, cosmetics, household items, textiles and electronics. Given the extent of human exposure to AgNPs, information about the toxicological effects of such products is required to ensure their safety.
Adriana Rodriguez-Garraus, Amaya Azqueta, Ariane Vettorazzi, Adela López de Cerain   +3 more
openaire   +4 more sources

Cis-trimethoxystilbene, exhibits higher genotoxic and antiproliferative effects than its isomer trans-trimethoxystilbene in MCF-7 and MCF-10A cell lines

Genetics and Molecular Biology, 2021
Stilbenes are a class of natural compounds with a wide variety of biological effects, such as antitumor activity. The best-known stilbene is resveratrol, whose clinical application is limited due to its low bioavailability.
Natália dos Santos Gonçalves, Tamires Maria Silva Pereira de Mello, Cássia Suemi Mizuno, Saqlain Haider, Raquel Alves dos Santos   +4 more
doaj   +1 more source

A second DNA binding site in human BRCA2 promotes homologous recombination

Nature Communications, 2016
BRCA2 is a well-characterized central player in homologous recombination in which it functions as the RAD51 loader. Here the authors identify an N-terminal region of BRCA2 that binds DNA and promotes efficient DNA repair.
Catharina von Nicolai, Åsa Ehlén, Charlotte Martin, Xiaodong Zhang, Aura Carreira   +4 more
doaj   +1 more source

Evaluation of Cytotoxic and Genotoxic Risk Derived from Exposure to Pesticides in Corn Producers in Tlaxcala, Mexico

Applied Sciences, 2022
Corn cultivation represents the largest type of agricultural production in Mexico, with great economic, social, and cultural importance. The health of corn producers could be compromised by the extensive and accumulated use of pesticides.
Antonio Rivera, Lilia Cedillo Ramírez, Conrado Parraguirre Lezama, Alfredo Baez Simon, Beatriz Laug Garcia, Omar Romero-Arenas   +5 more
doaj   +1 more source

Cytotoxic and Genotoxic Evaluation of the Aqueous and Hydroalcoholic Leaf and Bark Extracts of Crataegus oxyacantha in Murine Model

Plants, 2021
Crataegus oxyacantha has been mainly used in traditional medicine for the treatment of cardiovascular diseases. However, its safety profile has not been fully established, since only the genotoxic effects of C.
Fany Renata Aguilera-Rodríguez, Ana Lourdes Zamora-Perez, Clara Luz Galván-Moreno, Rosalinda Gutiérrez-Hernández, Claudia Araceli Reyes Estrada, Edgar L. Esparza-Ibarra, Blanca Patricia Lazalde-Ramos   +6 more
doaj   +1 more source

Effects of Cry1Ab Transgenic Maize on Lifecycle and Biomarker Responses of the Earthworm, Eisenia Andrei

Sensors, 2012
A 28-day study was conducted to determine the effects of the Bacillus thuringiensis Cry1Ab toxin on the earthworm Eisenia andrei. Previously, investigations have been limited to life-cycle level effects of this protein on earthworms, and mostly on E ...
Mark Maboeta, Johnnie van den Berg, Frances van der Merwe, Carlos Bezuidenhout   +3 more
doaj   +1 more source

Assessment of Formalin Teratogenicity on Embryos of Pregnant Albino Rats [PDF]

The Egyptian Journal of Histology, 2020
Background: Formaldehyde (FA) is an economically important chemical that is commonly used in the production of industrial, laboratory, household, and cosmetic products.
Fardous Al-Kalaa, Magdy ElBordiny, melad kelada, Aliaa El-Alkamy   +3 more
doaj   +1 more source

Cytogenetic Study on the Biostimulation Potential of the Aqueous Fruit Extract of Hippophae rhamnoides for a Sustainable Agricultural Ecosystem

Plants, 2020
This cytogenetic study evaluates the biostimulation potential of the aqueous extract of seabuckthorn fruits (AESF) in plant cells, using the Allium cepa species as a test plant. The effects were monitored both at the macroscopic and microscopically level.
Elena Bonciu, Aurel Liviu Olaru, Elena Rosculete, Catalin Aurelian Rosculete   +3 more
doaj   +1 more source

Nitrosodimethylamine impurities in metformin drug products: Physician insight

Journal of Diabetology, 2021
Metformin is a high-dose antidiabetic drug and most widely used first-line therapeutic agent for the management of type 2 diabetes mellitus (T2DM).
Chetan Doshi, Rajkumar Malayandi, Gajanan Namjoshi, Pramod Kadam, Dhananjay Mule   +4 more
doaj   +1 more source