Results 31 to 40 of about 73,191 (264)
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
ChemistryOpenNatural substances play a crucial role in modern medicine by targeting cellular pathways associated with diseases. Medicinal plants, rich in bioactive compounds, offer promising therapeutic potential. This study examines the phytochemicals and biological
Muhammad Naseer +6 more
doaj +1 more source
Journal of Experimental Life Science, 2017 Pesticides are recognized as serious pollutants in the aquatic environment with the potential to cause genotoxic on the aquatic organism, especially fish.
R Adharyan Islamy +2 more
doaj +1 more source
Acta Scientiarum Polonorum: Hortorum Cultus, 2022 This study aims to determine the effects of tebuconazole substance used at different doses on the quality of tomato seedlings, retrotransposon mobility caused by this substance in the plants and its genotoxic effects and to determine the optimum dose to
Halil İbrahim Öztürk +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Evaluation of micronuclei in potentially malignant disorders and oral cancers: A cytological assay
Journal of Indian Academy of Oral Medicine and Radiology, 2023 Objective: The present study aims to evaluate the number of micronuclei (MN) in potentially malignant disorders (PMDs) and oral cancer and correlates them with the control group.
Aishwarya Bhatnagar +5 more
doaj +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”
Frontiers in PharmacologyMany medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic.
Ghanya Al-Naqeb +7 more
doaj +1 more source
Threshold of Toxicological Concern—An Update for Non-Genotoxic Carcinogens
Frontiers in Toxicology, 2021 The Threshold of Toxicological Concern (TTC) concept can be applied to organic compounds with the known chemical structure to derive a threshold for exposure, below which a toxic effect on human health by the compound is not expected.
Monika Batke +8 more
doaj +1 more source