Results 211 to 220 of about 73,191 (264)

The genotoxicity of lead

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
C, Winder, T, Bonin
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Genotoxicity of phytoestrogens

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
H, Stopper, E, Schmitt, K, Kobras
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Genotoxicity of phthalates

Toxicology Mechanisms and Methods, 2014
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Overview of genotoxic carcinogens and non-genotoxic carcinogens

Experimental and Toxicologic Pathology, 1992
It is known that carcinogens designated on the basis of longterm animal test results are extremely diverse in character, both in terms of potencies and the mechanism of action, which leads to complexity in their assessment for cancer risk to humans. The classification of carcin0ogens into two categories, namely, genotoxic and non-genotoxic varieties ...
exaly   +3 more sources

Genotoxic and non-genotoxic pathways of p53 induction

Cancer Letters, 2001
Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
O, Pluquet, P, Hainaut
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Interaction and distinction of genotoxic and non-genotoxic events in carcinogenesis

Toxicology Letters, 1992
Multistage carcinogenesis involves genotoxic as well as non-genotoxic mechanisms. The importance of genotoxic events in human carcinogenesis is apparent from the analysis of tumours: for example, five to six genetic alterations can be found in most malignant colorectal tumours. While such measurable "footprints" (e.g. ras, p53 mutations) can be left in
Marc Mesnil
exaly   +3 more sources

Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion

Food and Chemical Toxicology, 1999
Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J, O'Donoghue, E D, Barber, T, Hill, J, Aebi, L, Fiorica   +4 more
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Genotoxicity of HNE

Molecular Aspects of Medicine, 2003
Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Genotoxicity

2021
The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
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The genotoxicity of selenium

Mutation Research/Reviews in Genetic Toxicology, 1985
Selenium at nutritional levels has been shown to have numerous anticarcinogenic or preventative effects against carcinogen-induced breast, colon, liver and skin cancer in animals. Many of these anticarcinogenic effects have been summarized. In addition, numerous mutagenic and antimutagenic effects of selenium compounds have been reported.
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