Results 221 to 230 of about 73,191 (264)
Some of the next articles are maybe not open access.
2003
Bacterial mutagenesis assays have been used as preliminary screens for the evaluation of chemicals because they are rapid, simple, and are correlated with carcinogeneity in humans (1). The activation of bacterial DNA repair systems (recently reviewed; 2,3) can be used as a measure of mutagenic and genotoxic effects of various chemical as well as ...
openaire +3 more sources
Bacterial mutagenesis assays have been used as preliminary screens for the evaluation of chemicals because they are rapid, simple, and are correlated with carcinogeneity in humans (1). The activation of bacterial DNA repair systems (recently reviewed; 2,3) can be used as a measure of mutagenic and genotoxic effects of various chemical as well as ...
openaire +3 more sources
Genotoxicity and genotoxic enhancing effect of tetrandrine in Salmonella typhimurium
Mutation Research/Genetic Toxicology, 1989Tetrandrine has been used for the treatment of silicosis in China. The potential genotoxic and carcinogenic hazards of this drug were studied using the Salmonella/histidine reversion assay and the SOS/Umu test. The results show that tetrandrine was weakly mutagenic to Salmonella typhimurium TA98 with metabolic activation and did not induce SOS response.
W Z, Whong +4 more
openaire +2 more sources
Genotoxicity and anti-genotoxicity of some traditional medicinal herbs
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005Six herbal infusions used worldwide (Matricaria chamomilla, Tilia cordata, Mentha piperita, Mentha pulegium, Uncaria tomentosa and Valeriana officinalis) were assayed for anti-genotoxicity using the Somatic Mutation And Recombination Test (SMART) in Drosophila melanogaster.
Magdalena, Romero-Jiménez +4 more
openaire +2 more sources
Genotoxicity evaluation of trimethylbenzenes
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 1998The three trimethyl isomers of benzene (hemimellitene, 1,2,3-TMB; pseudocumene, 1,2,4-TMB and mesitylene, 1,3,5-TMB) were investigated for different genotoxicity endpoints: in vitro, in the Ames test with Salmonella typhimurium TA97a, TA98, TA100 and TA102 strains in the presence and absence of rat liver S9 metabolic activation; in vivo, in the ...
E, Janik-Spiechowicz +2 more
openaire +2 more sources
Transplacental genotoxicity of diethylstilbestrol
Carcinogenesis, 1991Diethylstilbestrol (DES) is a transplacental carcinogen in humans and in rodents. As part of an attempt to examine the mechanism of transplacental carcinogenesis, the transplacental genotoxity of this stilbene estrogen has been investigated. Pregnant hamsters received single injections of 200 mg/kg DES on the 10th day of gestation and were killed 5 or ...
A, Gladek, J G, Liehr
openaire +2 more sources
Azathioprine, a genotoxic agent to be considered non-genotoxic in man
Mutation Research/Reviews in Genetic Toxicology, 1989Azathioprine, an immunosuppressive drug, has been used for 25 years. Azathioprine is rapidly converted into a number of metabolites after absorption. Maximum blood levels in experimental animals (mice) were 11.3 micrograms/ml after a dosage of 33.3 mg/kg. Generally, levels of less than 1 microgram/ml are found.
openaire +2 more sources
Mutation Research/Reviews in Genetic Toxicology, 1991
L F, Povirk, M J, Austin
openaire +2 more sources
L F, Povirk, M J, Austin
openaire +2 more sources
Genotoxic and Non-Genotoxic Chemicals for Review of the Performance Improved Genotoxicity
2020Shiv Shankar Shukla +3 more
openaire +1 more source