Results 241 to 250 of about 65,731 (278)
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Quantifying genotoxicity and non-genotoxicity
Mutation Research/Genetic Toxicology, 1988Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
H S, Rosenkranz, F K, Ennever
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Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
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With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo +4 more
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Genotoxicity of Streptozotocin
Mutation Research/Reviews in Mutation Research, 2002Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 1993
Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
C, Winder, T, Bonin
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Lead has been tested for genotoxic potential in a range of mutagenicity assays. Such studies report varying effects, and the results are equivocal. The reasons for this may be related to problems of the solubility of many lead compounds, their inability to dissolve in biological fluids, chemical interferences resulting in conflicting observations, the ...
C, Winder, T, Bonin
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Genotoxicity of phytoestrogens
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
H, Stopper, E, Schmitt, K, Kobras
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Genotoxic and non-genotoxic pathways of p53 induction
Cancer Letters, 2001Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
O, Pluquet, P, Hainaut
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Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion
Food and Chemical Toxicology, 1999Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J, O'Donoghue +4 more
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2021
The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
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The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
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Mutation Research/Reviews in Genetic Toxicology, 1985
Selenium at nutritional levels has been shown to have numerous anticarcinogenic or preventative effects against carcinogen-induced breast, colon, liver and skin cancer in animals. Many of these anticarcinogenic effects have been summarized. In addition, numerous mutagenic and antimutagenic effects of selenium compounds have been reported.
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Selenium at nutritional levels has been shown to have numerous anticarcinogenic or preventative effects against carcinogen-induced breast, colon, liver and skin cancer in animals. Many of these anticarcinogenic effects have been summarized. In addition, numerous mutagenic and antimutagenic effects of selenium compounds have been reported.
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Molecular Aspects of Medicine, 2003
Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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