Results 141 to 150 of about 120,679 (294)

α-Hexylcinnamaldehyde synergistically increases doxorubicin cytotoxicity towards human cancer cell lines [PDF]

, 2016
α-Hexylcinnamaldehyde (HCA), a compound derived from cinnamaldehyde, was evaluated for its potential chemosensitizing ...
DI GIACOMO, Silvia, DI SOTTO, Antonella, El Readi, Mahmoud Zaki, Mazzanti, Gabriela, Wink, Michael   +4 more
core  

Binding of Hg(I) and Hg(II) Ions to Amyloid‐Beta (Aβ) Peptide Variants Affect their Structure and Aggregation

ChemBioChem, EarlyView.
Mercury (Hg) is a possible risk factor for Alzheimer's disease, where neuronal death is related to amyloid brain plaques containing aggregated amyloid‐β (Aβ) peptides. We show that equimolar Hg(I) or Hg(II) ions inhibit normal Aβ aggregation. Hg(II) binds Aβ(1–40) with an apparent binding affinity 28 ± 8 μM.
Elina Berntsson, Andra Noormägi, Kärt Padari, Jüri Jarvet, Astrid Gräslund, Margus Pooga, Peep Palumaa, Sebastian K. T. S. Wärmländer   +7 more
wiley   +1 more source

Glutathione Threshold‐Triggered Selective Breakability of Organosilica Nanocapsules

ChemCatChem, EarlyView.
Replacing tetraethoxy orthosilicate (TEOS) by tetramethoxy orthosilicate (TMOS) as silica precursor to synthesize cleavable organosilica nanocapsules enabled the effective and selective entrapment of a positively charged protein as Cytochrome C (CytC) and a much more favorable breakability and kinetics release when exposed to high glutathione (GSH ...
Andrea Mosseri, Ana Rueda‐Flores, Jose L. Hueso, Esteban Urriolabeitia, Luisa De Cola, Jesus Santamaria   +5 more
wiley   +1 more source

Identification of Promoters Bound by c-Jun/ATF2 during Rapid Large-Scale Gene Activation following Genotoxic Stress [PDF]

, 2004
Jun Hayakawa, Shalu Mittal, Yipeng Wang, Kemal Korkmaz, Eileen D. Adamson, Christopher N. English, M. Omichi, Michael McClelland, Dan Mercola   +8 more
openalex   +1 more source

Monitoring Apoptotic Activity of Silver(I) Metallodrugs Containing Mefenamic Acid and Mitochondriotropic Agents in Artificial Breast Tumor Tissues

ChemMedChem, EarlyView.
MCF‐7 cancer cell cultures in 2D and 3D systems before and after 48 h of treatment with silver complexes of mefenamic acid. The results highlight the biological effectiveness of these compounds in advanced cellular models. The anticancer potential of silver(I) metallodrugs incorporating mefenamic acid and mitochondriotropic agents in 3D spheroid models
Christina N. Banti, Sotiris K. Hadjikakou   +1 more
wiley   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, EarlyView.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Xylose Acetals ‐ a New Class of Sustainable Solvents and Their Application in Enzymatic Polycondensation

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
Novel organic solvents with an unmodified carbohydrate core were synthesised both from D‐xylose and directly from biomass and were successfully used as reaction media for lipase biocatalysts to synthesise aliphatic and aromatic polyesters. Abstract The use of organic solvents in academic research and industry applications is facing increasing ...
Anastasia O. Komarova, Cicely M. Warne, Hugo Pétremand, Laura König‐Mattern, Johannes Stöckelmaier, Chris Oostenbrink, Georg M. Guebitz, Jeremy Luterbacher, Alessandro Pellis   +8 more
wiley   +1 more source

Chemical composition and antigenotoxic properties of Lippia alba essential oils

Genetics and Molecular Biology, 2011
The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity.
Molkary Andrea López, Elena E. Stashenko, Jorge Luis Fuentes   +2 more
doaj  

Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster [PDF]

, 2008
Denise Gonçalves Pereira, Lusânia Maria Greggi Antunes, Ulrich Gräf, Mário Antônio Spanó   +3 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source