Results 211 to 220 of about 35,705 (247)

Quantifying genotoxicity and non-genotoxicity

Mutation Research/Genetic Toxicology, 1988
Since the ability to induce genotoxicity is often equated with the potential for initiating the carcinogenic process, a method for quantitating genotoxicity would provide a useful measure for this potential. It is demonstrated herein that CPBS, the Carcinogenicity Prediction and Battery Selection method, provides a useful quantitative measure of ...
H S, Rosenkranz, F K, Ennever
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Genotoxicity

2021
The assessment of the potential of a new drug to cause genotoxicity is a prerequisite for its progression to clinical development. This chapter gives a concise overview of the major aspects relating to genotoxicity, which are relevant in small molecule drug discovery. Testing schemes and assays recommended by regulatory guidelines are outlined.
Stephan Kirchner, Patrick Schnider
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Genotoxicity of Nanocarriers

Current Drug Metabolism, 2018
With the rapid development of nanoparticles in drug delivery system, a lot of interest in the genotoxicity evaluation of nanocarriers has emerged currently. Here our emphasis was placed on the summary of studies on standard genotoxicity assays.We performed a PubMed/MEDLINE search for all publications in the English language related to assessment of ...
Ting, Luo, Long, Gao, Xiaowei, Chen, Ke, Xu, Meng, Niu   +4 more
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Genotoxicity of Streptozotocin

Mutation Research/Reviews in Mutation Research, 2002
Streptozotocin (Streptozocin, STZ, CAS No. 18883-66-4) is a monofunctional nitrosourea derivative isolated from Streptomyces achromogenes. It has broad spectrum antibiotic activity and antineoplastic properties and is often used to induce diabetes mellitus in experimental animals through its toxic effects on pancreatic beta cells.
Alejandro D, Bolzán, Martha S, Bianchi
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Genotoxic Sensors

2003
Bacterial mutagenesis assays have been used as preliminary screens for the evaluation of chemicals because they are rapid, simple, and are correlated with carcinogeneity in humans (1). The activation of bacterial DNA repair systems (recently reviewed; 2,3) can be used as a measure of mutagenic and genotoxic effects of various chemical as well as ...
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Ethanol-induced genotoxicity

Mutation Research Letters, 1985
Unrelated, nondenatured, ethanol preparations, derived synthetically or by fermentation, were found to induce qualitatively similar concentration-dependent toxic and genotoxic effects as measured by RK mutatest. In this system ethanol was found genotoxic above a threshold concentration of 18-19% (v/v) when RK+ selector cells were transiently exposed ...
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Genotoxic and non-genotoxic pathways of p53 induction

Cancer Letters, 2001
Since the initial concept of p53 as a sensor of DNA-damage, the picture of the role of p53 has widened to include the sensing of much more diverse forms of stress, including hypoxia and constitutive activation of growth-promoting cascades. The pathways by which these processes regulate p53 are partially overlapping, but imply different patterns of post-
O, Pluquet, P, Hainaut
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Genotoxicity of phthalates

Toxicology Mechanisms and Methods, 2014
Many of the environmental, occupational and industrial chemicals are able to generate reactive oxygen species (ROS) and cause oxidative stress. ROS may lead to genotoxicity, which is suggested to contribute to the pathophysiology of many human diseases, including inflammatory diseases and cancer.
Pınar, Erkekoglu, Belma, Kocer-Gumusel
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Genotoxicity of phytoestrogens

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 2005
Plant extracts containing phytohormones are very popular as 'alternative' medicine for many kinds of diseases. They are especially favored by women who enter menopause and are concerned about the side effects of hormone replacement therapy. However, adverse health effects of phytoestrogens have often been ignored. This review examines the literature on
H, Stopper, E, Schmitt, K, Kobras
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Hydroquinone: Genotoxicity and Prevention of Genotoxicity Following Ingestion

Food and Chemical Toxicology, 1999
Plant-derived polyphenolics and other chemicals with antioxidant properties have been reported to inhibit the expression of genotoxic activity by pro-oxidant chemicals (Sai et al., 1992, 1994; Teel and Castonguay, 1992). In vitro and in vivo studies with ionizing radiation suggest that hydroquinone (HQ) may have similar protective effects (Babaev et al.
J, O'Donoghue, E D, Barber, T, Hill, J, Aebi, L, Fiorica   +4 more
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