Results 191 to 200 of about 56,006 (307)

Attitudes Toward Prenatal Interventions in the Fanconi Anemia Community

Prenatal Diagnosis, EarlyView.
ABSTRACT Objective In‐utero cell and gene therapies may offer prenatal treatment options for inherited diseases. Preclinical data suggests in‐utero (IU) hematopoietic stem cell transplantation (HSCT) could prevent Fanconi anemia (FA) related bone marrow failure without genotoxic conditioning or immune suppression.
Tony Lum, Catherine Lee, Tippi MacKenzie, Billie Lianoglou, Agnieszka Czechowicz   +4 more
wiley   +1 more source

Preliminary Genotoxicity Assessment of Calcium Phosphate Cement Incorporated with Palm Tocotrienol Using Bacterial Reverse Mutation Assay. [PDF]

Biomedicines
Wong SK, Md Dali SS, Chin KY, Ahmad F, Ariffin AH, Fauzi FM, Mahmud MZ, Ahmad Sabri IH.   +7 more
europepmc   +1 more source

In Utero HSC Transplantation for Sickle Cell Disease: A Potential Therapeutic Approach That Overcomes Complications of Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide but has limited treatment options, most of which carry significant side effects. At present, the only curative treatment for SCD is allogeneic or gene‐modified autologous hematopoietic stem cell (HSC) transplantation (Tx).
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Deep learning and object detection methods for scoring cell types within the human buccal cell micronucleus and cytome assays for human biomonitoring. [PDF]

Mutagenesis
Smith E, Wagman J, Barnes C, Rees P, Johnson G.   +4 more
europepmc   +1 more source

Sickle Cell Disease: Historical Overview and Current Therapies

Prenatal Diagnosis, EarlyView.
ABSTRACT Sickle cell disease (SCD) affects millions worldwide, yet the limited treatment options currently available do not always adequately control the disease and carry significant side effects. At present, the only curative treatment is hematopoietic stem cell (HSC) transplantation, a procedure that carries considerable challenges and numerous ...
Oluwaseun O. Babatunde, Madeleine G. Bibby, Anthony Atala, Graça Almeida‐Porada, Christopher D. Porada   +4 more
wiley   +1 more source

Prediction of primary human targets and toxicity mechanisms of imidacloprid using integrative <i>In Silico</i> approaches. [PDF]

Toxicol Rep
Boonyong C, Powthong P.
europepmc   +1 more source

GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry

, 2022
L. van Grunsven, T. Vanhaecke, A. Thienpont, B. Mertens, S. Verhulst, V. Rogiers   +5 more
core  

Ashwagandha: Is It Safe? Part 2: A Preclinical Evidence Review

Phytotherapy Research, EarlyView.
ABSTRACT The preclinical evidence for the safety of ashwagandha (Withania somnifera (L.) Dunal, AS) is reviewed, and its preparations (extracts) and constituents, from the general toxicity in animal models to in vitro and cell culture studies, which may elucidate mechanisms of action and explain clinical case reports.
Elizabeth M. Williamson, Thomas Brendler
wiley   +1 more source

Single-cell multiplex approaches deeply map ON-target CRISPR-genotoxicity and reveal its mitigation by palbociclib and long-term engraftment. [PDF]

Nat Commun
Boutin J, Fayet S, Marin V, Bergès C, Riandière M, Toutain J, Lamrissi-Garcia I, Thibault C, Cappellen D, Dabernat S, Poulet A, Francillette M, Droin N, Debeissat C, Brunet de la Grange P, Moreau-Gaudry F, Bedel A.   +16 more
europepmc   +1 more source

The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects)

, 2023
E. Cho, T. Vanhaecke, A. Williams, A. Thienpont, B. Mertens, S. Verhulst, V. Rogiers, C. Yauk   +7 more
core