Results 171 to 180 of about 125,041 (360)
Journal of Applied Toxicology, EarlyView.ABSTRACT Toxicological assessment is essential in NP approval for health and medical applications. Although 2D cell culture has been widely used, 3D models, especially spheroids, provide better predictive value for toxicological risk assessments since they replicate complex cellular interactions more accurately.
Bianca Montenegro +5 more
wiley +1 more source
Immunomodulatory and Cytotoxic Properties of Enniatin B1 in Porcine Alveolar Macrophages
Journal of Applied Toxicology, EarlyView.ABSTRACT This study investigates the immunomodulatory effects of Enniatin B1 (ENNB1), an emerging mycotoxin, on porcine alveolar macrophages (PAMs), a species‐specific model relevant to human innate immunity. PAMs were exposed to increasing ENNB1 concentrations (0.5–6 μM) over 6, 24, and 48 h.
Sara Frazzini +4 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza +2 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT The present study aimed to quantify pesticide residues in environmental matrices and plasma and to evaluate their potential effects on oxidative stress and DNA damage in rural populations of Santa Fe province. Soil and rainwater samples were collected, and biological samples and semistructured surveys were obtained from volunteers in three ...
María Priscila Dechiara +4 more
wiley +1 more source
Cultivation of hMSCs in Human Plasma Prevents the Cytotoxic and Genotoxic Potential of ZnO-NP In Vitro [PDF]
, 2019 Agmal Scherzad +7 more
openalex +1 more source
Effect of Zinc Oxide Nanoparticles From Infant Formula Milk Powder on Colon Cells In Vitro
Journal of Applied Toxicology, EarlyView.ABSTRACT Zinc is an essential trace element that participates in numerous metabolic processes; however, excessive exposure may interfere with the absorption of other metals, such as copper. In recent years, nanotechnology has experienced rapid growth, and zinc oxide nanoparticles (ZnO NPs) have garnered significant attention due to their versatile ...
Gloria Salinas‐Lucero +2 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Moringa oleifera Lam. seeds contain WSMoL, a lectin previously studied for toxicity and pharmacological effects. In this study, we investigated WSMoL (10, 25, or 50 mg/kg i.p.) for acute and 14‐day repeated‐dose toxicity, as well as genotoxicity, in Swiss mice.
Alícia Natalie Silva dos Santos +10 more
wiley +1 more source
Journal of Applied Toxicology, EarlyView.ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó +3 more
wiley +1 more source