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Genotoxicity testing strategies
Toxicology in Vitro, 1994Genotoxicity tests contribute to the assessment of whether a chemical has the potential to cause somatic or germ-cell effects in animals (i.e. the potential to induce cancer or heritable mutation). Such genotoxicity testing is usually undertaken in a stepwise approach; first an assessment in vitro, to determine intrinsic genotoxic activity, and ...
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Molecular Aspects of Medicine, 2003
Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Since previous investigations on the genotoxicity of 4-hydroxynonenal (HNE) were carried out with prokaryotic systems or eukaryotic cell lines which may not adequately reflect the response of cells in vivo due to differences in the metabolism, the genotoxic potential of HNE was further evaluated in primary cells (hepatocytes) and cell clones of ...
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Genotoxicity and anti-genotoxicity of some traditional medicinal herbs
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2005Six herbal infusions used worldwide (Matricaria chamomilla, Tilia cordata, Mentha piperita, Mentha pulegium, Uncaria tomentosa and Valeriana officinalis) were assayed for anti-genotoxicity using the Somatic Mutation And Recombination Test (SMART) in Drosophila melanogaster.
Magdalena, Romero-Jiménez +4 more
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Overview of genotoxic carcinogens and non-genotoxic carcinogens
Experimental and Toxicologic Pathology, 1992It is known that carcinogens designated on the basis of longterm animal test results are extremely diverse in character, both in terms of potencies and the mechanism of action, which leads to complexity in their assessment for cancer risk to humans. The classification of carcin0ogens into two categories, namely, genotoxic and non-genotoxic varieties ...
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Mutation Research/Reviews in Genetic Toxicology, 1991
L F, Povirk, M J, Austin
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L F, Povirk, M J, Austin
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