Results 271 to 280 of about 56,006 (307)
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Azathioprine, a genotoxic agent to be considered non-genotoxic in man
Mutation Research/Reviews in Genetic Toxicology, 1989Azathioprine, an immunosuppressive drug, has been used for 25 years. Azathioprine is rapidly converted into a number of metabolites after absorption. Maximum blood levels in experimental animals (mice) were 11.3 micrograms/ml after a dosage of 33.3 mg/kg. Generally, levels of less than 1 microgram/ml are found.
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Metabolism and Genotoxicity of Dihaloalkanes
1994Publisher Summary The most thoroughly studied of the dihaloalkanes is ethylene dibromide. Considerable evidence now exists to support the view that glutathione (GSH) conjugation is critical to mutagenicity and probably tumorigenesis. The major DNA adduct is S-[2-(N7-guanyl)ethylglutathione and this adduct is most likely to be responsible for the ...
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Genotoxic and Non-Genotoxic Chemicals for Review of the Performance Improved Genotoxicity
2020Shiv Shankar Shukla +3 more
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Genotoxic carcinogen or not genotoxic carcinogen? That is the question
Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2009Richard M. Walmsley, Nicholas Billinton
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Genotoxicity and non-genotoxicity of chemical carcinogens
Toxicology Letters, 1998V.N. Rakitsky +3 more
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Mechanisms of genotoxicity. A review ofin vitroandin vivostudies with engineered nanoparticles
Nanotoxicology, 2014Zuzana Magdolenova +2 more
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