Results 281 to 290 of about 123,177 (344)

Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

Cell Proliferation, EarlyView.
Aberrant condensates formed through phase separation are involved in the dysregulation of various critical cellular processes, including genome stability, transcriptional regulation and signal transduction, thereby promoting malignant transformation and the acquisition of multiple cancer hallmarks.
Chen‐chen Xie, Ting Wang, Xin‐ran Liu, Yan Wang, Qin Dang, Tian Ding, Jia‐qi Xu, Xian‐jun Yu, Hai Lin, Xiao‐wu Xu, Yi Qin   +10 more
wiley   +1 more source

Revisiting the genotoxic syndrome: Why are we overlooking the ecological impacts of genotoxins on animal populations? [PDF]

Genet Mol Biol
Ellwanger JH, Ziliotto M, Chies JAB.
europepmc   +1 more source

Biosynthesis of ZnO nanocomposites from Mentha spicata applications of antioxidant, antimicrobial and genotoxicity advances in MCF-7 cell line

Azhagu Madhavan Sivalingam
openalex   +1 more source

The Role of SAMHD1 in Viral Resistance and Transduction Efficiency Challenges in Pediatric Hematological Malignancies: Mechanistic Insights and Clinical Perspectives

European Journal of Haematology, EarlyView.
SAMHD1 regulates intracellular dNTP pools, influencing lentiviral transduction, gene therapy efficiency, and disease progression in pediatric hematological malignancies. Integrated bioinformatics and targeted strategies, including CRISPR and pharmacological inhibition, highlight its therapeutic potential.
Waseem Alzamzami
wiley   +1 more source

Understanding the cellular uptake and genotoxic potential of industrial relevant nanomaterials utilizing electron microscopy and the ToxTracker assay in vitro. [PDF]

Mutagenesis
Evans SJ, Moelijker N, Brandsma I, Burgum MJ, Elespuru R, Hendriks G, Doak SH.   +6 more
europepmc   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, EarlyView.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

In Vitro Cytotoxic and Genotoxic Evaluation of Nitazenes, a Potent Class of New Synthetic Opioids. [PDF]

J Xenobiot
Rombolà F, Bartoletti S, Bilel S, Hrelia P, Marti M, Lenzi M.   +5 more
europepmc   +1 more source

Application of in vitro erythropoiesis from bone marrow derived progenitors to detect and study genotoxicity

, 2007
Joseph F. Shuga
openalex   +1 more source

A novel approach to target skin photodamage: Topical application of salt inducible kinase inhibitors

International Journal of Cosmetic Science, EarlyView.
UV‐induced photodamage leads to increased DNA damage and elevated MMP levels, which degrade collagen and contribute to wrinkle formation. SLT‐001 and SLT‐008, novel cosmetic ingredients that target salt‐inducible kinase, help reverse this effect by enhancing DNA repair, reducing MMP expression and decreasing erythema, thereby mitigating photodamage ...
Inbal Rachmin, Béatrice Le Varlet, Claire Regazzetti, Thierry Passeron, Jinhua Wang, David E. Fisher, Philippe Schaison, Braham Shroot   +7 more
wiley   +1 more source

Assessment of Genotoxicity and Cytotoxicity of Tepary Bean (<i>Phaseolus acutifolius</i>) Seed Protein Extract. [PDF]

Life (Basel)
Valadez-Vega C, Ortigoza-Fonseca L, Betanzos-Cabrera G, Velasco-Azorsa R, Muñoz-Pérez VM, Morales-González JA, Velázquez-Morales BP, Bernardino-Nicanor A, González-Cruz L, Estrada-Luna D, Lugo-Magaña O.   +10 more
europepmc   +1 more source