Results 41 to 50 of about 56,006 (307)

Acute immobilization assay with Daphnia similis: A miniaturized protocol

NAM Journal
To reduce volume of samples, residues, costs and time, ecotoxicologists are seeking for new approach methodologies. Miniaturized versions of already well-established protocols are arising as a promising tool to diminish costs and residues in the ...
João Gabriel Mesquita Silva, Gabriela Russi de Oliveira, Ádria Caloto de Oliveira, Anjaina Fernandes de Albuquerque, Francine Inforçato Vacchi, Paula Suares-Rocha, Gisela de Aragão Umbuzeiro   +6 more
doaj   +1 more source

Optimisation of an automated high-throughput micronucleus (HiTMiN) assay to measure genotoxicity of environmental contaminants

, 2022
Anthropogenic contaminants can have a variety of adverse effects on exposed organisms, including genotoxicity in the form of DNA damage. One of the most commonly used methods to evaluate genotoxicity in exposed organisms is the micronucleus (MN) assay ...
Finlayson, Kimberly, Leusch, Frederic DL, Shelper, Todd, Johnson, Matthew, van de Merwe, Jason P   +4 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Scientific Opinion on Flavouring Group Evaluation 213, Revision 2 (FGE.213Rev2): Consideration of genotoxic potential for α,β‐unsaturated alicyclic ketones and precursors from chemical subgroup 2.7 of FGE.19

EFSA Journal, 2015
The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) of the European Food Safety Authority (EFSA) was requested to evaluate the genotoxic potential of 26 flavouring substances from subgroup 2.7 of FGE.19 in Flavouring
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)
doaj   +1 more source

Toxic and genotoxic potential evaluation of soil samples by bioassays

Acta Agriculturae Slovenica, 2005
Soil samples were obtained from Slovenian industrial region Šaleška dolina and aqueous leachates were prepared. The toxicity and genotoxicity potential of these aqueous fractions have been evaluated by in vitro toxicity and genotoxicity bioassays ...
Barbara LAH, Miha AVBERŠEK, Gregor GORJANC, Romana MARINŠEK LOGAR   +3 more
doaj   +1 more source

Flavouring Group Evaluation 217 Revision 3 (FGE.217Rev3): consideration of genotoxic potential for α,β‐unsaturated ketones and precursors from chemical subgroup 4.1 of FGE.19: lactones

EFSA Journal, 2023
The Panel on Food Additives and Flavourings of the European Food Safety Authority was requested to evaluate the genotoxic potential of four flavouring substances [FL‐no: 10.023, 10.030, 10.057 and 13.012] from subgroup 4.1 of FGE.19.
EFSA Panel on Food Additives and Flavourings (FAF), Maged Younes, Gabriele Aquilina, Laurence Castle, Gisela Degen, Karl‐Heinz Engel, Paul J Fowler, Maria José Frutos Fernandez, Peter Fürst, Ursula Gundert‐Remy, Rainer Gürtler, Trine Husøy, Melania Manco, Peter Moldeus, Sabina Passamonti, Romina Shah, Ine Waalkens‐Berendsen, Matthew Wright, Romualdo Benigni, Claudia Bolognesi, Kevin Chipman, Eugenia Cordelli, Maria Carfì, Wim Mennes   +23 more
doaj   +1 more source

Genotoxic and stress inductive potential of cadmium in Xenopus laevis larvae [PDF]

, 2006
The present investigation evaluates the toxic potential of Cd in larvae of the frog Xenopus laevis after 12 days of exposure to environmentally relevant contamination levels, close to those measured in the river Lot (France).
Gauthier, Laury, Gonzalez, Patrice, Boudou, Alain, Bourdineaud, Jean-Paul, Mouchet, Florence, Baudrimont, Magalie, Cuenot, Y.   +6 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Genotoxicity evaluation of alpha-linolenic acid-diacylglycerol oil

Toxicology Reports, 2016
The alpha-linolenic acid (ALA)-diacylglycerol (DAG) oil is an edible oil enriched with DAG (>80%) and ALA (>50%). Although DAG oil, which mainly consists of oleic and linoleic acids has no genotoxic concerns, the fatty acid composition could affect the ...
Hiroshi Honda, Yurika Fujita, Aya Hayashi, Naohiro Ikeda, Yuichi Ito, Osamu Morita   +5 more
doaj   +1 more source

Controlling disinfection byproducts from treated wastewater using adsorption with granular activated carbon: Impact of pre-ozonation and pre-chlorination

Water Research X, 2020
This study measured chlorine- and chloramine-reactive precursors using formation potential (FP) tests of nine U.S. Environmental Protection Agency (EPA) regulated and 57 unregulated disinfection byproducts (DBPs) in tertiary-filtered wastewater before ...
Edgard M. Verdugo, Mac Gifford, Caitlin Glover, Amy A. Cuthbertson, Rebecca A. Trenholm, Susana Y. Kimura, Hannah K. Liberatore, Susan D. Richardson, Benjamin D. Stanford, R. Scott Summers, Eric R.V. Dickenson   +10 more
doaj   +1 more source