New direct contact approach to evaluate soil genotoxicity using the Vicia faba micronucleus test. [PDF]
, 2009 A method to assess micronucleus (MN) induction in Vicia faba roots by direct contact exposure to a solid matrix was developed. The procedure comprised a 5-d germination period, as in the well-known method using aqueous extracts.
Cecchi, M. +6 more
core +1 more source
Journal of Oral Biology and Craniofacial Research, 2019 Objectives: Impaired plasminogen activator inhibitor-1 (PAI-1), controlling coagulation and the fibrinolytic system is supposed to be involved in the pathogenesis of periodontitis.
Puja Debnath +7 more
doaj +1 more source
Evaluation of extracts of wild Cannabis sativa L. for genotoxicity and phytochemical composition
Caryologia, 2021 Cannabis sativa L. is used as medicine and narcotic in Lesotho. Phytochemical composition and total phenolics content (TPC) for hexane, chloroform, ethyl acetate a methanol extracts of aerial parts of C. sativa were determined.
Asita Asita +3 more
doaj +1 more source
Assessment of the genotoxicity of Cu and Zn in raw and anaerobically digested slurry with the Vicia faba micronucleus test [PDF]
, 2009 Genotoxicity of Cu and Zn was assessed by use of the micronucleus (MN) test on Vicia faba roots. Plants were exposed to various leachates of rawand anaerobically digested pig slurry, with maximum total concentrations of 200MCu and 600MZn.
Marcato, Claire-Emmanuelle +5 more
core +1 more source
Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells
Journal of Pharmacological Sciences, 2009 Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer.
Neetu Singh +5 more
doaj +1 more source
Comparative Evaluation of Genotoxicity of Captan in Amphibian Larvae (Xenopus laevis and Pleurodeles waltl) Using the Comet Assay and the Micronucleus Test [PDF]
, 2006 Captan (N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide) is a fungicide used to inhibit the growth of many types of fungi on plants used as foodstuffs.
Gauthier, Laury +8 more
core +1 more source
Biomonitoring of the genotoxic potential of aqueous extracts of soils and bottom ash resulting from municipal solid waste incineration, using the comet and micronucleus tests on amphibian (Xenopus laevis) larvae and bacterial assays (MutatoxR and Ames tests) [PDF]
, 2006 The management of contaminated soils and wastes is a matter of considerable human concern. The present study evaluates the genotoxic potential of aqueous extracts of two soils (leachates) and of bottom ash resulting from municipal solid waste ...
Gauthier, Laury +11 more
core +1 more source
martinschatz-cz/genotoxicity-bia: v1.0.0
, 2023 BioImage Processing and Analysis for In vitro genotoxicity testing using γH2AX biomarker, microscopy and automatic image analysis in ImageJ The data analysis workflow consists of several stages, each of which was executed by a specific script.
Křížkovská, Bára +2 more
core +1 more source
Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?
Journal of Nucleic Acids, 2010 Although the Comet assay, a procedure for quantitating DNA damage in mammalian cells, is considered sensitive, it has never been ascertained that its sensitivity is higher than the sensitivity of other genotoxicity assays in mammalian cells. To determine
Satomi Kawaguchi +4 more
doaj +1 more source
Frontiers in Public Health, 2017 Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu +7 more
doaj +1 more source