Evaluation of extracts of wild Cannabis sativa L. for genotoxicity and phytochemical composition
Caryologia, 2021 Cannabis sativa L. is used as medicine and narcotic in Lesotho. Phytochemical composition and total phenolics content (TPC) for hexane, chloroform, ethyl acetate a methanol extracts of aerial parts of C. sativa were determined.
Asita Asita +3 more
doaj +1 more source
Genotoxicity and Cytotoxicity Exerted by Pesticides in Different Biotic Matrices-An Overview of More Than a Decade of Experimental Evaluation [PDF]
, 2014 Agrochemicals represent one of the most important sources of environmental pollution. Although attempts to reduce agrochemical use through organic agricultural practices and the use of other technologies to control pests continue, the problem is still
Larramendy, Marcelo Luis +3 more
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Caspase Mediated Enhanced Apoptotic Action of Cyclophosphamide- and Resveratrol-Treated MCF-7 Cells
Journal of Pharmacological Sciences, 2009 Cyclophosphamide (CPA) is a widely used chemotherapeutic drug for neoplasias. It is a DNA and protein alkylating agent having a broad spectrum of activity against a variety of neoplasms including breast cancer.
Neetu Singh +5 more
doaj +1 more source
Scientific Opinion on Flavouring Group Evaluation 57, Revision 1 (FGE.57Rev1): consideration of isopulegone and three flavouring substances evaluated by JECFA (55th meeting) [PDF]
, 2017 Publisher ...
Anastassiadou, Maria +26 more
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In Vitro Mutagenic and Genotoxic Assessment of a Mixture of the Cyanotoxins Microcystin-LR and Cylindrospermopsin [PDF]
, 2019 The co-occurrence of various cyanobacterial toxins can potentially induce toxic effects different than those observed for single cyanotoxins, as interaction phenomena cannot be discarded. Moreover, mixtures are a more probable exposure scenario. However,
Cameán Fernández, Ana María +4 more
core +1 more source
Mutagenic impact on fish of runoff events in agricultural areas in south-west France [PDF]
, 2011 When heavy rainfall follows herbicide application, the intense surface runoff causes stream water contamination. Aquatic organisms are then briefly exposed to a complex mixture of contaminants.
Gauthier, Laury +6 more
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Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay.
PLoS ONE, 2023 Toxicity evaluation of engineered nanomaterials is challenging due to the ever increasing number of materials and because nanomaterials (NMs) frequently interfere with commonly used assays.
Maelle Fontaine +13 more
doaj +1 more source
Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]
, 2017 Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena +9 more
core +1 more source
Is the Comet Assay a Sensitive Procedure for Detecting Genotoxicity?
Journal of Nucleic Acids, 2010 Although the Comet assay, a procedure for quantitating DNA damage in mammalian cells, is considered sensitive, it has never been ascertained that its sensitivity is higher than the sensitivity of other genotoxicity assays in mammalian cells. To determine
Satomi Kawaguchi +4 more
doaj +1 more source
Frontiers in Public Health, 2017 Genotoxicity and carcinogenicity testing of pharmaceuticals prior to commercialization is requested by regulatory agencies. The bacterial mutagenicity test was considered having the highest accuracy of carcinogenic prediction.
Qianying Liu +7 more
doaj +1 more source