Results 61 to 70 of about 89,616 (295)

Assessment of the genotoxicity of olive mill waste water (OMWW) with the Vicia faba micronucleus test [PDF]

, 2007
The present study concerns the genotoxicity of olive mill waste water (OMWW) generated in mills producing olive oil in Morocco. The Vicia faba micronucleus test was used to evaluate the genotoxicity of OMWW and the six major phenolic compounds identified
El Hajjouji, Houda, Guiresse, Agnès Maritchù, Hafidi, Mohamed, Merlina, Georges, Pinelli, Eric, Revel, Jean-Claude   +5 more
core   +3 more sources

Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs

Molecular Oncology, EarlyView.
In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza, David James, Emma Creagh, James T. Murray   +3 more
wiley   +1 more source

Mechanisms and Assessment of Genotoxicity of Metallic Engineered Nanomaterials in the Human Environment

Biomedicines
Engineered nanomaterials (ENMs) have a broad array of applications in agriculture, engineering, manufacturing, and medicine. Decades of toxicology research have demonstrated that ENMs can cause genotoxic effects on bacteria, mammalian cells, and animals.
Benjamin M. Liu, A. Wallace Hayes
doaj   +1 more source

Summarized data of genotoxicity tests for designated food additives in Japan

Genes and Environment, 2018
The Ministry of Health, Labour and Welfare has carried out genotoxicity tests for food additives used in Japan in cooperation with the Japan Food Additives Association since 1979. Hayashi et al.
Masami Yamada, Masamitsu Honma
doaj   +1 more source

A comparative genotoxicity study of a supraphysiological dose of triiodothyronine (T₃) in obese rats subjected to either calorie-restricted diet or hyperthyroidism. [PDF]

PLoS ONE, 2013
This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals.
Maria Teresa De Sibio, Renata Azevedo Melo Luvizotto, Regiane Marques Castro Olimpio, Camila Renata Corrêa, Juliana Marino, Miriane de Oliveira, Sandro José Conde, Ana Lúcia dos Anjos Ferreira, Carlos Roberto Padovani, Célia Regina Nogueira   +9 more
doaj   +1 more source

Safety assessment of the substance dimethyl carbonate for use in food contact materials [PDF]

, 2017
Publisher ...
Bolognesi, Claudia, Castle, Laurence, Cravedi, Jean-Pierre, Croera, Cristina, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kolf-Clauw , Martine, Kärenlampi, Sirpa, Lampi, Eugenia, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Svensson, Kettil, Tavares Poças, Maria de Fátima, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +24 more
core   +2 more sources

Olaparib synergy screen reveals Exemestane induces replication stress in triple‐negative breast cancer

Molecular Oncology, EarlyView.
Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh, Liping Su, Suet Lin Chia, Xiaohe Tian, Haslina Ahmad, Martin R. Gill   +5 more
wiley   +1 more source

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster

Genetics and Molecular Biology, 2014
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the ...
Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade   +6 more
doaj   +1 more source

Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro

Journal of Nanobiotechnology, 2021
Background Toxicological evaluation of engineered nanomaterials (ENMs) is essential for occupational health and safety, particularly where bulk manufactured ENMs such as few-layer graphene (FLG) are concerned.
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak   +6 more
doaj   +1 more source

Lead Uptake, Toxicity, and Detoxification in Plants [PDF]

, 2011
Lead has gained considerable attention as a persistent toxic pollutant of concern, partly because it has been prominent in the debate concerning the growing anthropogenic pressure on the environment.
Dumat, Camille, Pinelli, Eric, Pourrut, Bertrand, Shahid, Muhammad, Winterton, Peter   +4 more
core   +3 more sources