Results 61 to 70 of about 123,177 (344)

Effects of artichoke (Cynara scolymus) leaf and bloom head extracts on chemically induced DNA lesions in Drosophila melanogaster

Genetics and Molecular Biology, 2014
The genotoxicity of bloom head (BHE) and leaf (LE) extracts from artichoke (Cynara scolymus L.), and their ability to modulate the mutagenicity and recombinogenicity of two alkylating agents (ethyl methanesulfonate - EMS and mitomycin C - MMC) and the ...
Laura Vicedo Jacociunas, Rafael Rodrigues Dihl, Mauricio Lehmann, Alexandre de Barros Falcão Ferraz, Marc François Richter, Juliana da Silva, Heloísa Helena Rodrigues de Andrade   +6 more
doaj   +1 more source

A comparative genotoxicity study of a supraphysiological dose of triiodothyronine (T₃) in obese rats subjected to either calorie-restricted diet or hyperthyroidism. [PDF]

PLoS ONE, 2013
This study was designed to determine the genotoxicity of a supraphysiological dose of triiodothyronine (T3) in both obese and calorie-restricted obese animals.
Maria Teresa De Sibio, Renata Azevedo Melo Luvizotto, Regiane Marques Castro Olimpio, Camila Renata Corrêa, Juliana Marino, Miriane de Oliveira, Sandro José Conde, Ana Lúcia dos Anjos Ferreira, Carlos Roberto Padovani, Célia Regina Nogueira   +9 more
doaj   +1 more source

Safety assessment of the substance dimethyl carbonate for use in food contact materials [PDF]

, 2017
Publisher ...
Bolognesi, Claudia, Castle, Laurence, Cravedi, Jean-Pierre, Croera, Cristina, EFSA Panel on Food Contact Materials Enzymes, Flavourings and Processing Aids (CEF), Engel, Karl-Heinz, Fowler, Paul, Franz, Roland, Grob, Konrad, Gürtler, Rainer, Husøy, Trine, Kolf-Clauw , Martine, Kärenlampi, Sirpa, Lampi, Eugenia, Mennes, Wim, Milana, Maria Rosaria, Penninks, André, Silano, Vittorio, Smith, Andrew, Svensson, Kettil, Tavares Poças, Maria de Fátima, Tlustos, Christina, Wölfle, Detlef, Zorn, Holger, Zugravu, Corina-Aurelia   +24 more
core   +3 more sources

Signs of deferasirox genotoxicity [PDF]

Cytotechnology, 2013
Iron overload is a major health problem for patients who have to have continuous blood transfusions. It brings some metabolic problems together. Various iron chelating agents are being used for treatment of hemochromatosis which arises from excess iron accumulation.
Ila, Hasan Basri, Topaktas, Mehmet, Arslan, Mehmet, Buyukleyla, Mehmet   +3 more
openaire   +4 more sources

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Summarized data of genotoxicity tests for designated food additives in Japan

Genes and Environment, 2018
The Ministry of Health, Labour and Welfare has carried out genotoxicity tests for food additives used in Japan in cooperation with the Japan Food Additives Association since 1979. Hayashi et al.
Masami Yamada, Masamitsu Honma
doaj   +1 more source

Few-layer graphene induces both primary and secondary genotoxicity in epithelial barrier models in vitro

Journal of Nanobiotechnology, 2021
Background Toxicological evaluation of engineered nanomaterials (ENMs) is essential for occupational health and safety, particularly where bulk manufactured ENMs such as few-layer graphene (FLG) are concerned.
Michael J. Burgum, Martin J. D. Clift, Stephen J. Evans, Nicole Hondow, Afshin Tarat, Gareth J. Jenkins, Shareen H. Doak   +6 more
doaj   +1 more source

A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals. [PDF]

, 2019
A database of 91 chemicals with published data from both transgenic rodent mutation (TGR) and rodent comet assays has been compiled. The objective was to compare the sensitivity of the two assays for detecting genotoxicity.
Aardema, MJ, Beevers, C, Bhalli, J, Douglas, GR, Escobar, PA, Farabaugh, CS, Guerard, M, Johnson, GE, Kirkland, D, Kulkarni, R, Le Curieux, F, LeBaron, MJ, Levy, DD, Long, AS, Lott, J, Lovell, DP, Luijten, M, Marchetti, F, Nicolette, JJ, Pfuhler, S, Roberts, DJ, Stankowski, LF, Thybaud, V, Weiner, SK, Williams, A, Witt, KL, Young, R   +26 more
core   +3 more sources

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

Genotoxic and antigenotoxic medicinal plant extracts and their main phytochemicals: “A review”

Frontiers in Pharmacology
Many medicinal plant extracts have been proven to have significant health benefits. In contrast, research has shown that some medicinal plant extracts can be toxic, genotoxic, mutagenic, or carcinogenic.
Ghanya Al-Naqeb, Ghanya Al-Naqeb, Aliki Kalmpourtzidou, Francesca Giampieri, Francesca Giampieri, Rachele De Giuseppe, Hellas Cena, Hellas Cena   +7 more
doaj   +1 more source