Results 51 to 60 of about 2,304,211 (377)

Predicting the effectiveness of hepatitis C virus neutralizing antibodies by bioinformatic analysis of conserved epitope residues using public sequence data [PDF]

, 2018
Hepatitis C virus (HCV) is a global health issue. Although direct-acting antivirals are available to target HCV, there is currently no vaccine. The diversity of the virus is a major obstacle to HCV vaccine development. One approach toward a vaccine is to
Cowton, Vanessa M., Gifford, Robert J., Patel, Arvind H., Singer, Joshua B.   +3 more
core   +2 more sources

Standardizing CYP2D6 Genotype to Phenotype Translation: Consensus Recommendations from the Clinical Pharmacogenetics Implementation Consortium and Dutch Pharmacogenetics Working Group

Clinical and Translational Science, 2019
Translating CYP2D6 genotype to metabolizer phenotype is not standardized across clinical laboratories offering pharmacogenetic (PGx) testing and PGx clinical practice guidelines, such as the Clinical Pharmacogenetics Implementation Consortium (CPIC) and ...
K. Caudle, K. Sangkuhl, Michelle Whirl‐Carrillo, J. Swen, Cyrine E. Haidar, T. Klein, Roseann S. Gammal, M. Relling, S. Scott, D. Hertz, H. Guchelaar, A. Gaedigk   +11 more
semanticscholar   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Seeds Mineral Profile and Ash Content of Thirteen Different Genotypes of Cultivated and Wild Cardoon over Three Growing Seasons

Agriculture
Cultivated and wild cardoons are versatile plants with significant economic and bioactive potential. They have gained attention in recent years for their nutritional value and potential health benefits due to their high mineral content and unique ...
Marina Giménez-Berenguer, Salvatore Alfio Salicola, Claudia Formenti, María José Giménez, Giovanni Mauromicale, Pedro Javier Zapata, Sara Lombardo, Gaetano Pandino   +7 more
doaj   +1 more source

IMMUNOGENETIC PECULIARITIES OF IL-1Β SYNTHESIS IN THE PATIENTS WITH PROTRACTED AND CHRONIC (RECURRENT) BACTERIAL INFLAMMATION OF UPPER RESPIRATORY WAYS (RHINOSINUSITIS)

Медицинская иммунология, 2014
We have studied distribution of IL-1β gene allelic variants (-511C>Т polymorphism in promoter region and IL-1β +3953C>Т polymorphism in exon 5) in sixty-two patients with recurrent and protracted rhinosinusitis, as well as their intercorrelations ...
L. F. Aznabaeva, E. R. Sharipova, N. A. Arefyeva, A. G. Zainullina   +3 more
doaj   +1 more source

A Genotypic-oriented View of CFTR Genetics Highlights Specific Mutational Patterns Underlying Clinical Macro-categories of Cystic Fibrosis. [PDF]

, 2015
Cystic Fibrosis (CF) is a monogenic disease caused by mutations of the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene. The genotype-phenotype relationship in this disease is still unclear, and diagnostic, prognostic and therapeutic ...
Amato, Annalisa, Bertasi, Serenella, Bruno, SABINA MARIA, Cimino, G., Ferraguti, Giampiero, Lucarelli, Marco, Narzi, Fabiana, Pierandrei, Silvia, Quattrucci, Serena, Stamato, Antonella, Strom, Roberto   +10 more
core   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

HPV Genotype Trends in Iran: Necessity for a Reevaluation of Prevention Strategies

Tropical Medicine and Infectious Disease
Introduction: Human papillomavirus (HPV) genotyping is critical for preventing and managing HPV-related health issues, including cancers. This study re-evaluates HPV genotype trends in Iran to inform prevention strategies.
Maryam Shahi, Azam Shafaei, Mohamad Ghodsi, Reza Jafarzadeh Esfehani, Mahdi Moradi Marjaneh   +4 more
doaj   +1 more source

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Epidemiological features of viral hepatitis C in the Tomsk region

Инфекция и иммунитет
Introduction. Despite the great advances made in the field of virology and their diagnostics, a number of difficulties affect improvements in the control and elimination of hepatitis C virus (HCV) infection at present.
Yu. A. Ermolaeva, I. R. Grishkevich, Yu. G. Samoilova   +2 more
doaj   +1 more source