Results 51 to 60 of about 1,614,514 (332)

Genetic Risk of MASLD in Mongolians: Role of PNPLA3 and FTO SNPs

Current Issues in Molecular Biology
Background: This study aimed to determine the association between PNPLA3 rs738409, rs2896019, and FTO rs9939609, rs17817449 single-nucleotide polymorphisms and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD) in Mongolian ...
Yumchinsuren Tsedendorj, Dolgion Daramjav, Yesukhei Enkhbat, Ganchimeg Dondov, Gantogtokh Dashjamts, Enkhmend Khayankhyarvaa, Amin-Erdene Ganzorig, Bolor Ulziitsogt, Tegshjargal Badamjav, Batbold Batsaikhan, Shiirevnyamba Avirmed, Tulgaa Lonjid   +11 more
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

MOLECULAR CHARACTERIZATION OF ROTAVIRUSES ISOLATED FROM CALVES WITH BOVINE NEONATAL DIARRHEA (BND) IN COLOMBIA

Infectio, 2018
Bovine rotaviruses are one of the main agents involved in the presentation of Bovine Neonatal Diarrhea (BND), a disease that affects calves in the first month of life.
Dolly Pardo-Mora
doaj   +1 more source

The Long-Term Impact of Rotavirus Vaccines in Korea, 2008–2020; Emergence of G8P[8] Strain

Vaccines, 2021
This study evaluated the long-term impact of rotavirus vaccination on prevalence, seasonality, and genotype distribution in Gwangju, Korea for 13 seasons.
Kwang gon Kim, Hye-young Kee, Hye jung Park, Jae Keun Chung, Tae sun Kim, Min Ji Kim   +5 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Phenotypical and genotypical resistance testing of Pasteurella multocida isolated from different animal species in Austria

Frontiers in Veterinary Science
IntroductionPasteurella multocida is an economically important pathogen in veterinary medicine. Data on its antimicrobial resistance vary widely across regions. Furthermore, most of the found literature focuses on phenotypic resistance testing.
Leonard Barta, Anna Stöger, Daniel Polzer, Werner Ruppitsch, Friedrich Schmoll, Tatjana Sattler, Tatjana Sattler   +6 more
doaj   +1 more source

Root and Leaf Anatomy, Ion Accumulation, and Transcriptome Pattern under Salt Stress Conditions in Contrasting Genotypes of Sorghum bicolor [PDF]

, 2023
Appa Rao Karumanchi, Pramod Sivan, Kummari Divya, G. Rajasheker, S. Anil Kumar, Palakolanu Sudhakar Reddy, Prashanth Suravajhala, Sudhakar Podha, P. B. Kavi Kishor   +8 more
openalex   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Gene Regulatory Changes Associated With Phenological Transitions in an Ecologically Significant Tree Species

Plant-Environment Interactions
Climate change is driving earlier spring leaf‐out across temperate regions, but the genetic mechanisms and environmental interactions underlying this variability are poorly understood.
Theresa Caso‐McHugh, David L. Des Marais, Miranda Oseguera, Meghan Blumstein   +3 more
doaj   +1 more source