Priors for Genotyping Polyploids [PDF]
Bioinformatics, 2019 AbstractMotivationEmpirical Bayes techniques to genotype polyploid organisms usually either (i) assume technical artifacts are knowna priorior (ii) estimate technical artifacts simultaneously with the prior genotype distribution. Case (i) is unappealing as it places the onus on the researcher to estimate these artifacts, or to ensure that there are no ...
Gerard, David +1 more
openaire +4 more sources
Association Study of Vitamin D Receptor (VDR) - Related Genetic Polymorphisms and their Haplotypes with Chronic Periodontitis in Colombian Population [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: There is strong evidence that both genetic and environmental factors may affect the periodontal clinical status. However, epidemiological evidence on the association between Vitamin D Receptor (VDR) polymorphisms and Chronic ...
Sergio Iván Tobón-Arroyave +2 more
doaj +1 more source
Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Science, 2018 HLA genotype affects response Immunotherapy works by activating the patient's own immune system to fight cancer. For effective tumor killing, CD8+ T cells recognize tumor peptides presented by human leukocyte antigen class I (HLA-I) molecules. In humans,
D. Chowell +19 more
semanticscholar +1 more source
Genotyping—From Genomic DNA to Genotype in a Single Tube [PDF]
Angewandte Chemie International Edition, 2005 AbstractNucleotide variations in the human genome, such as single‐nucleotide polymorphisms, have been researched more intensively since it became apparent that these deviations are linked to various diseases and also several side effects of drugs. The investigation of genomic DNA in the laboratory requires routine methods that are time‐, labour‐, and ...
Strerath, Michael, Marx, Andreas
openaire +4 more sources
Advanced Biomedical Research, 2014 Background: Hypertension is a public health challenge due to its high prevalence, and is a major risk factor for cardiovascular diseases. This study was designed to determine the frequency of the I/D polymorphism of the angiotensin-converting enzyme gene
Mary Esien Kooffreh +2 more
doaj +1 more source
A Correlative Study of Sunflower Seed Vigor Components as Related to Genetic Background
Plants, 2020 Seed vigor is an important trait that determines seed performance in the field, which corresponds to seed germination rate and seedling establishment.
Marine Saux +4 more
doaj +1 more source
Statistical theory of phenotype abundance distributions: a test through exact enumeration of genotype spaces [PDF]
Europhysics Letters 123, 28001 (2018), 2018 The evolutionary dynamics of molecular populations are strongly dependent on the structure of genotype spaces. The map between genotype and phenotype determines how easily genotype spaces can be navigated and the accessibility of evolutionary innovations.
arxiv +1 more source
Cryptosporidium rubeyi n. sp. (Apicomplexa: Cryptosporidiidae) in multiple Spermophilus ground squirrel species. [PDF]
, 2015 Previously we reported the unique Cryptosporidium sp. "c" genotype (e.g., Sbey03c, Sbey05c, Sbld05c, Sltl05c) from three species of Spermophilus ground squirrel (Spermophilus beecheyi, Spermophilus beldingi, Spermophilus lateralis) located throughout ...
Atwill, Edward R +7 more
core +3 more sources
A Genotype-Guided Strategy for Oral P2Y12 Inhibitors in Primary PCI.
New England Journal of Medicine, 2019 BACKGROUND It is unknown whether patients undergoing primary percutaneous coronary intervention (PCI) benefit from genotype-guided selection of oral P2Y12 inhibitors.
Daniel M. F. Claassens +19 more
semanticscholar +1 more source
Automated SNP genotype clustering algorithm to improve data completeness in high-throughput SNP genotyping datasets from custom arrays [PDF]
, 2007 High-throughput SNP genotyping platforms use automated genotype calling algorithms to assign genotypes. While these algorithms work efficiently for individual platforms, they are not compatible with other platforms, and have individual biases that result
Edward M. Smith +15 more
core +2 more sources