Results 61 to 70 of about 1,493,018 (273)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

A rotavirus VP4 or VP7 monoreassortant panel identifies genotypes that are less susceptible to neutralization by systemic antibodies induced by vaccination or natural infection

mBio
Rotavirus infections remain a significant cause of morbidity and mortality in infants. The viral surface proteins VP4 and VP7 are each classified into multiple genotypes (P[1]–P[58] for VP4 and G1–G42 for VP7), which differ in their susceptibility to ...
Tomohiro Kotaki, Yuta Kanai, Kristen M. Ogden, Megumi Onishi, Kattareeya Kumthip, Pattara Khamrin, Patcharaporn Boonyos, Pornkamol Phoosangwalthong, Phakapun Singchai, Tipsuda Luechakham, Shohei Minami, Zelin Chen, Katsuhisa Hirai, Ratana Tacharoenmuang, Hiroto Mizushima, Hiroshi Ushijima, Niwat Maneekarn, Takeshi Kobayashi   +17 more
doaj   +1 more source

Eating behaviours and food cravings; influence of age, sex, BMI and FTO genotype [PDF]

, 2019
Previous studies indicate that eating behaviours and food cravings are associated with increased BMI and obesity. However, the interaction between these behaviours and other variables such as age, sex, BMI and genetics is complex.
Caroline Dalton, David Broom, Dawn Hadden, Hallam, Hameida El Farssi, Hanan Abdella   +5 more
core   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Impact of Spontaneous Fermentation on the Physicochemical and Sensory Qualities of Cacao

Fermentation
Fermentation is a fundamental technique that allows us to obtain high-quality cacao beans and derived products. Therefore, it is necessary to apply fermentation correctly to maximize product quality.
Lucas Fernando Quintana-Fuentes, Alberto García-Jerez, Ana Carolina Rodríguez-Negrette, Nurys Tatiana Hoyos-Merlano, Armando Alvis-Bermúdez   +4 more
doaj   +1 more source

Impact of apolipoprotein B-associated cholesterol deficiency genotype on milk composition, somatic cell count, and parity effects in Lithuanian Holstein cows [PDF]

Veterinary World
Background and Aim: Cholesterol deficiency (CD) in Holstein cattle, caused by a loss-of-function mutation in the apolipoprotein B (APOB) gene, is a heritable autosomal recessive condition with known implications for fat metabolism and cholesterol ...
Ramutė Mišeikienė, Nijolė Pečiulaitienė, Lina Kajokienė, Renata Bižienė, Kristina Morkūnienė, Vilius Marma, Saulius Tušas, Paulius Matusevičius, Ewa Wójcik, Alina Janocha, Anna Milczarek, Laimutis Kučinskas   +11 more
doaj   +1 more source

Improving stress coping ability: comparison between the CYP17 genotype Of Ovis Aries and Capra Hircus [PDF]

, 2010
The ability of animals to adapt to stress is not only an animal health and welfare concern, but also influences reproduction potential and robustness. An important pathway involved in the stress response is the hypothalamic-pituitary-adrenal axis (HPAA ...
Cloete, S.W.P., Hough, D., Storbeck, K., Swart, P.   +3 more
core  

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Distinguished Loop-Mediated Isothermal Amplification Assay to Detect Porcine Epidemic Diarrhea Virus Genotypes I and II

Veterinary Sciences
Porcine epidemic diarrhea virus (PEDV), a primary pathogen causing diarrhea in pigs, particularly in piglets, has a mortality rate of up to 100%. Field PEDV strains circulating in pig production can be phylogenetically divided into two genotypes, GI and ...
Zhong Liu, Lanlan Li, Mengtao Fang, Xiaoqing Wei, Jieqiong Li, Qi Wu, Xiaoxue Yang, Yu Ye, Gen Wan, Dongyan Huang, Deping Song   +10 more
doaj   +1 more source

How does SCYLV genetic diversity impact on Sugarcane disease resistance and breeding? [PDF]

, 2012
To date, six distinct genotypes of the Sugarcane yellow leaf virus have been described in the literature (BRA, CUB, CHN1, IND, PER and REU). However, little information is available regarding the impact of virus genetic diversity on disease resistance ...
Daugrois, Jean-Heinrich, Débibakas, Sarah   +1 more
core