Results 91 to 100 of about 706,514 (296)

A Hepatitis C Virus-Associated Chronic Hepatitis Patient Developing Various Adverse Events Including Severe Gingivitis, Gingival Bleeding, and Inflammation of Genital Vulva during the Course of Antiviral Therapy with Elbasvir/Grazoprevir

Case Reports in Gastroenterology, 2017
Oral direct-acting antivirals comprise the main therapy for hepatitis C virus (HCV)-associated liver disease in Japan. Daclatasvir/asunaprevir is the primary agent and sofosbuvir/ledipasvir is the secondary agent for HCV genotype 1b.
Kazuo Tarao, Akira Sato
doaj   +1 more source

Hepatitis C virus genotype 1b, cirrhosis, and risk of hepatocellular carcinoma [PDF]

Hepatology, 2008
n ...
Sangiovanni, Angelo, Iavarone, Massimo
openaire   +1 more source

Contenst, Vol. 55, N. 1B (2017)

, 2018
Contenst, Vol. 55, N.
2017, VJST Vol 55, N. 1B
core   +1 more source

Suboptimal SVR rates in African patients with atypical Genotype 1 subtypes: implications for global elimination of Hepatitis C [PDF]

, 2019
Direct acting antiviral medications are able to cure Hepatitis C in the majority of patients. The most common genotype of Hepatitis C in Europe and the United States is genotype 1a or 1b and most clinical trials focused on these genotypes. We report that
Agarwal, Kosh, Childs, Kate, Simmonds, Peter, Cannon, Mary, Tong, Lily, Thomson, Emma C., Dusheiko, Geoff, Thomson, Emma C, Davis, Christopher, Smith, Donald, Montague, Sarah, Filipe, Ana   +11 more
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Interleukin (IL)-1B and IL-1 receptor antagonist gene polymorphisms in children with primary immune thrombocytopenia [PDF]

Clinical and Experimental Pediatrics
Background The pathophysiology and susceptibility of children to primary immune thrombocytopenia (ITP) are linked to polymorphisms of the interleukin (IL)-1B and IL-1 receptor (IL-1R) antagonist genes.
Seham Mohamed Ragab, Wafaa Moustafa Abo ElFotoh, Mahmoud Ahmed El-Hawy, Eman Abdelfatah Badr, Saara Khairat Ali Mostafa, Mai El-Sayad Abd El-Hamid   +5 more
doaj   +1 more source

Comparison of the docking poses with NS3 proteases from sub-genotype 1a and 1b.

, 2013
(A) Docking poses of 12 colored in pink with the sub-genotype 1b NS3 protease (colored in tan). Compound 12 is colored in cyan when it was docked with the sub-genotype 1a NS3 protease (colored in cyan).
Susan L. Uprichard (261305), Tian Zhu (394135), Kavankumar Patel (468714), Joseph L. Gatuz (468718), Kirk E. Hevener (468717), Yan-Yan Zhang (468715), Lena Truong (468716), Gitanjali Subramanya (468719), Michael E. Johnson (468721), Hyun Lee (468713), Hyun-Young Jeong (468720)   +10 more
core   +1 more source

Frequency of CYP3A4*1B, CYP3A4*22 and CYP3A5*3 polymorphisms in the Croatian population

, 2022
Enzimi pod-porodice citokroma P450 3A (CYP3A) sudjeluju u metabolizmu oko 50% lijekova u kliničkoj primjeni. Najvažniji su enzimi CYP3A4 i CYP3A5, za koje je karakteristična interindividualna varijabilnost.
Petreković, Sandra
core   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source